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公开(公告)号：JPH08290066A
公开(公告)日：1996-11-05
申请号：JP9819195
申请日：1995-04-24
发明人： SAITO KYOICHI , KIYOHARA MEGUMI
摘要： PURPOSE: To improve low addition reaction efficiency due to uneven addition reaction of an amino acid by a graft-polymerizing polymerizable amino acid- bonded monomer obtained by the reaction of a polymerizable monomer and an amino acid, on a polymer material membrane. CONSTITUTION: An amino acid-bonded polymerizable monomer obtained by the reaction of a polymerizable monomer having a group reactive with an amino acid and a amino acid is graft-polymerized on a polymer material membrane to give a functional membrane. The polymer material membrane is a membrane of a polymer or a compolymer of an olefin and a halogenated olefin. The amino acid-bonded polymerizable polymer is an addition polymer of an amino acid and glycidyl methacrylate, glycidyl acrylate, glycidyl sorbate, glycidyl methaitaconate, ethylglycidyl maleate, or glycidyl vinylsulfonate. The polymerizable monomer is further graft-polymerized on a polymer material membrane to produce a functional membrane.
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公开(公告)号：JP2001072993A
公开(公告)日：2001-03-21
申请号：JP2000192408
申请日：2000-06-27
发明人： KIYOHARA MEGUMI , FUJITA SHIRO
IPC分类号： C11C1/08
摘要： PROBLEM TO BE SOLVED: To provide a method for selectively separating eicosapentaenoic acid and docosahexaenoic acid or esters thereof from a mixture containing highly unsaturated aliphatic acids or derivatives thereof and purifying the same. SOLUTION: A silver salt is supported on diatomaceous earth by making an aqueous medium containing the silver salt flow through a column filled with the diatomaceous earth. Next a solvent solution of a mixture containing highly unsaturated aliphatic acids or derivatives thereof is made to flow through the silver salt-containing diatomaceous earth in the column and then a developer is made to flow whereby eicosapentaenoic acid and docosahexaenoic acid or esters thereof are selectively separated and purified.
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公开(公告)号：JPH05107237A
公开(公告)日：1993-04-27
申请号：JP6810092
申请日：1992-03-26
IPC分类号： B01J20/28 , B01J20/281 , B01J20/283 , B01L99/00 , G01N30/56 , G01N30/88
摘要： PURPOSE:To provide a filling agent for liquid chromatography which facilitates high density and uniform filling by dry-process in satisfactory manner and is capable of realizing a high number of theoretical stages, and a column for liquid chromatography using the filling agent. CONSTITUTION:By constituting a filling agent for a liquid chromatography on a surface of a base of silica gel, etc., by carrying an ultra-fine particle powder such as ultra-fine particle silica gel, a flow behavior of the filling agent for the liquid chromatography is improved and the above purpose is achieved.
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公开(公告)号：JPH10201417A
公开(公告)日：1998-08-04
申请号：JP814597
申请日：1997-01-21
申请人： SUGOU KK , NISSHIN FLOUR MILLING CO
发明人： KATAOKA HISASHI , KIYOHARA MEGUMI
IPC分类号： A23L19/00 , A21D2/16 , A23D7/00 , A23D9/007 , A23D9/02 , A23L11/00 , A23L27/60 , A61K8/30 , A61K8/36 , A61K8/37 , A61K8/98 , C07C51/42 , C07C57/03 , A23L1/20 , A23L1/212 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide odorless and stabilized oil contg. highly unsatd. fatty acid and/or its ester, emulsified liquid of the oil and water and food and cosmetics added with the same. SOLUTION: The oil contg. the unscented and stabilized highly unsatd. fatty acid and/or its ester is obtd. by adding and mixing vinegar and/or citrus fruits juice to and with fish oil contg. the highly unsatd. fatty acid and/or its ester, then removing the water phase. The emulsified liquid and the food or cosmetics contg. the same are obtd. by emulsifying the oil and the water.
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公开(公告)号：JPH09225277A
公开(公告)日：1997-09-02
申请号：JP3627096
申请日：1996-02-23
发明人： KIYOHARA MEGUMI , SAITO KYOICHI
摘要： PROBLEM TO BE SOLVED: To enhance separating ability as well as to increase kinds of materials selected for a moving bed by using a separating membrane obtd. by graft- polymerizing a polymerizable monomer to a polymer substrate, bonding ion exchange groups to the resultant polymer membrane and making protein absorbed on the membrane. SOLUTION: Optical resolution is carried out with a separating membrane obtd. by graft-polymerizing a polymerizable monomer to a polymer substrate, bonding ion exchange groups to the resultant polymer membrane and making protein absorbed on the membrane or a separating membrane obtd. by graft- polymerizing a polymerizable monomer having an ion exchange group to a polymer substrate and making protein absorbed on the resultant polymer membrane. The separating membrane is utilized as an optical resolving membrane for analysis or separation owing to molecular asymmetry identifying ability peculiar to the adsorbed protein. The polymer substrate is made of a polymer or copolymer of olefin or halogenated olefin. The polymerizable monomer is, e.g. glycidyl methacrylate or glycidyl acrylate.
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公开(公告)号：JPH09313906A
公开(公告)日：1997-12-09
申请号：JP13997096
申请日：1996-06-03
发明人： KIYOHARA MEGUMI , SAITO KYOICHI
IPC分类号： B01J20/285 , B01D71/10 , B01D71/12 , B01D71/26 , B01D71/40 , B01D71/68 , B01D71/78 , C07K1/34 , C07K14/76 , C08F291/00 , C08L101/00 , G01N30/88 , G01N30/48
摘要： PROBLEM TO BE SOLVED: To freely change the strength of hydrophobic nature of a membrane surface. SOLUTION: A reverse phase separating membrane for separating protein is manufactured by graft polymerizing a porous polymer material membrane with a polymerizable monomer with a functional group of hydrophobic nature and another polymerizable monomer with a functional group of hydrophilic nature. As for the porous polymer material membrane, a membrane of a polymer or a copolymer of olefin or a halogenated olefin polyamide, a polyester, a polysulfone, a polyimide, cellulose or a cellulose derivative is used, and as a polymerizable monomer with a hydrophobic group, octadecyl (meth)acrylate or the like is used, and as the polymerizable monomer with a hydrophilic functional group, hydroxyethyl (meth)acrylate or the like is used.
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公开(公告)号：JPH0525123A
公开(公告)日：1993-02-02
申请号：JP17806591
申请日：1991-07-18
发明人： KIYOHARA MEGUMI , AKIYAMA HIROSHI
IPC分类号： A61K31/07 , A61P3/02 , C07C403/20 , C07D311/74
摘要： PURPOSE:To purify a vitamin A acid ester compound useful as a skin ulcer treating agent, a digestive tract ulcer treating agent and an antitumor agent in high separation ability with high recovery ratio and with high purity by an industrially applicable method. CONSTITUTION:A vitamin A acid ester compound such as compounds shown by formula I to formula III (X is group shown by formula IV and formula V; A and B are H or CH3; R1 and R2 are both H or either one is CH3 and the other is H; Y and Z are both H or Y and Z are mutually bonded), for example, obtained by esterifying wholly translentinoic acid or 1, 3-cis-lentinoic acid with tocopherol or vitamin D is purified at >=95% high recovery ratio at >=99% high purity industrially advantageously by using silica gel having 20-70mum average particle diameter and 100-180Angstrom average pore diameter as a column packing agent and an isopropyl ether-hexane mixed solvent having preferably 2-15% (v/v) isopropylene ether concentration as a mobile phase.
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公开(公告)号：JP2001131157A
公开(公告)日：2001-05-15
申请号：JP31526999
申请日：1999-11-05
发明人： YAMAZAKI HIROYUKI , KIYOHARA MEGUMI
IPC分类号： C07D241/04 , C07B57/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing optically 2-methylpiperazine having a highly optically active purity by optically resolving (±)-2-methylpiperazine. SOLUTION: This method for producing optically active 2-methylpiperazine, comprising a process for reacting 1 mole of (±)-2-methylpiperazine with 1 mole of an optically active tartaric acid selected from L-tartaric acid and D-tartaric acid to produce the 2-methylpiperazine.monotartarate as two kinds of the diastereomers and then utilizing the difference between the dissolution degrees of the diastereomers to deposit and separate one of the diastereomers, thus dissolving two kinds of the diastereomers in the crystals and the mother liquor, respectively, a process for further reacting with at least 1 mole of the same optically active tartaric acid to produce the 2-methylpiperazine.ditartarate as two kinds of the diastereomers and then utilizing the difference between the dissolution degrees of the diastereomers to deposit and separate one of the diastereomers, thus dissolving the two diastereomers in the crystals and the mother liquor, respectively, and so on.
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公开(公告)号：JPH10330781A
公开(公告)日：1998-12-15
申请号：JP15617897
申请日：1997-05-30
申请人： SUGOU KK , NISSHIN FLOUR MILLING CO
发明人： KATAOKA HISASHI , KIYOHARA MEGUMI
IPC分类号： A23C9/152 , A21D2/16 , A23D7/00 , A23D9/007 , A23L1/30 , A23L11/00 , A61K8/00 , A61K8/36 , A61K8/65 , A61K8/73 , A61K8/96 , A61K8/97 , A61K8/98 , A61Q19/00 , C09K15/34 , C11B5/00 , C11C3/00 , A23L1/20 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain an improved fish oil comps. which is odorless without emitting an unpleasant odor inherent in a fish oil even after a long storage or even when heated, and is excellent in storage stability and heat stability, an emulsion prepared therefrom, and foods and cosmetics contg. the compsn. or emulsion, and to provide a method for preparing the same. SOLUTION: An improved fish oil material is prepd. by mixing at least one fish oil material selected from among fish oils, highly unsatd. fatty acids derived from fish oils, and esters thereof with vinegar and/or a citrus fruit juice under stirring, leaving the resultant mixture standing, and separating and removing the water phase formed. The objective compsn. is prepd. by adding 10-120 pts.wt. vegetable oil alone or together with 0.05-1 pt.wt. at least one additive selected from among collagen, starch, and agar to 100 pts.wt. above-prepd. improved fish oil material.
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公开(公告)号：JPH0952032A
公开(公告)日：1997-02-25
申请号：JP20945395
申请日：1995-08-17
发明人： KIYOHARA MEGUMI , SAITO KYOICHI
IPC分类号： B01D71/10 , B01D71/12 , B01D71/26 , B01D71/30 , B01D71/48 , B01D71/56 , B01D71/68 , B01D71/78 , B01D71/82 , C08F251/00 , C08F251/02 , C08F255/00 , C08F259/00 , C08F283/00
摘要： PROBLEM TO BE SOLVED: To manufacture a superior reverse phase separating membrane which can select various functional groups in compliance with the nature of a material to be dealt with by graft polymerizing a polymerizable monomer provided with a hydrophobic functional group with a porous polymer material membrane. SOLUTION: A polymerizable monomer with a hydrophobic functional group such as octadecyl (meth)acrylate or tridecyl (meth)acrylate is graft polymerized with a porous polymer material membrane such as olefin or polyamide. Then, the hydrophobic functional group is fixed on a porous polymer membrane material. A polymer membrane thus formed is utilized as a reverse phase separating membrane for reverse phase column chromatography. A wide range of fixing amount of the hydrophobic functional group can be controlled by the membrane, and various functional groups can be selected in compliance with the nature of a material to be dealt with. As hydroxyl group is not contained in the membrane, separation can be carried out simply by the mutual action of the hydrophobic groups and a separation pattern of good reproducibility and without tailings can be provided.
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