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1.发明专利Composition having anticancer activity, containing ingredient extracted from cordyceps and/or mycelia-cultured solution thereof, and food and drug each containing the composition 审中-公开具有抗腐蚀活性的组合物，含有从其中提取的成分和/或MYCELIA培养的溶液，以及包含组合物的食品和药物
公开(公告)号：JP2012162479A
公开(公告)日：2012-08-30
申请号：JP2011023136
申请日：2011-02-04
Applicant: Nippon Tablet Kk , Ryoso:Kk , 日本タブレット株式会社 , 株式会社両双
Inventor： TONO MASAYUKI , FUJITA TAKANORI , FUKUDA YASUKI , HORIE HIROSHI , MATSUDA HIDEAKI , NISHIDA SHOZO , TSUBAKI MASAHIRO , MURATA KAZUYA
Abstract: PROBLEM TO BE SOLVED: To prevent or ameliorate cancer by compounding daily takable food with a composition with anticancer activity containing ingredients extracted from Cordyceps and/or its mycelia-cultured solution, or by compounding drugs with such a composition containing the ingredients.SOLUTION: Cordyceps and/or its mycelia-cultured solution is subjected to, according as needed, hot water extraction; subsequently, the Cordyceps and/or its mycelia-cultured solution, or a solution obtained by subjecting the Cordyceps and/or its mycelia-cultured solution to hot-water extraction, is subjected to hydrous alcohol extraction; subsequently, the resulting solution obtained by the hydrous alcohol extraction is subjected to reverse-phase column chromatography under predetermined conditions to make a crude fractionation to obtain fractions. Thereafter, a composition with anticancer activity containing ingredients contained in fractions with retention times of 4.4-5.5 min (fractions F2 to 4) among the fractions, is obtained. Using the composition, cancer can be prevented or ameliorated.
Abstract translation: 待解决的问题：通过将含有从虫草和/或其菌丝体培养溶液提取的成分的抗癌活性的组合物与每天可食用的食物混合，或通过将药物与含有该成分的组合物混合来预防或改善癌症。 解决方案：根据需要，将冬虫夏草和/或其菌丝体培养溶液进行热水提取; 然后将冬虫夏草和/或其菌丝体培养液或通过使冬虫夏草和/或其菌丝体培养溶液进行热水提取获得的溶液进行含水醇提取; 随后，通过含水醇提取得到的所得溶液在预定条件下进行反相柱色谱，以进行粗分馏以获得级分。 此后，得到含有馏分中保留时间为4.4〜5.5分钟（级分F2〜4）的馏分中含有成分的抗癌活性的组合物。 使用该组合物可以预防或改善癌症。 版权所有（C）2012，JPO＆INPIT
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