公开(公告)号：JP2012162479A

公开(公告)日：2012-08-30

申请号：JP2011023136

申请日：2011-02-04

Applicant: Nippon Tablet Kk ,  Ryoso:Kk ,  日本タブレット株式会社 ,  株式会社両双

Inventor： TONO MASAYUKI ,  FUJITA TAKANORI ,  FUKUDA YASUKI ,  HORIE HIROSHI ,  MATSUDA HIDEAKI ,  NISHIDA SHOZO ,  TSUBAKI MASAHIRO ,  MURATA KAZUYA

IPC: A61K35/64 ,  A23L1/30 ,  A61K36/06 ,  A61P35/00

Abstract: PROBLEM TO BE SOLVED: To prevent or ameliorate cancer by compounding daily takable food with a composition with anticancer activity containing ingredients extracted from Cordyceps and/or its mycelia-cultured solution, or by compounding drugs with such a composition containing the ingredients.SOLUTION: Cordyceps and/or its mycelia-cultured solution is subjected to, according as needed, hot water extraction; subsequently, the Cordyceps and/or its mycelia-cultured solution, or a solution obtained by subjecting the Cordyceps and/or its mycelia-cultured solution to hot-water extraction, is subjected to hydrous alcohol extraction; subsequently, the resulting solution obtained by the hydrous alcohol extraction is subjected to reverse-phase column chromatography under predetermined conditions to make a crude fractionation to obtain fractions. Thereafter, a composition with anticancer activity containing ingredients contained in fractions with retention times of 4.4-5.5 min (fractions F2 to 4) among the fractions, is obtained. Using the composition, cancer can be prevented or ameliorated.

Abstract translation: 待解决的问题：通过将含有从虫草和/或其菌丝体培养溶液提取的成分的抗癌活性的组合物与每天可食用的食物混合，或通过将药物与含有该成分的组合物混合来预防或改善癌症。 解决方案：根据需要，将冬虫夏草和/或其菌丝体培养溶液进行热水提取; 然后将冬虫夏草和/或其菌丝体培养液或通过使冬虫夏草和/或其菌丝体培养溶液进行热水提取获得的溶液进行含水醇提取; 随后，通过含水醇提取得到的所得溶液在预定条件下进行反相柱色谱，以进行粗分馏以获得级分。 此后，得到含有馏分中保留时间为4.4〜5.5分钟（级分F2〜4）的馏分中含有成分的抗癌活性的组合物。 使用该组合物可以预防或改善癌症。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2011236133A

公开(公告)日：2011-11-24

申请号：JP2010106634

申请日：2010-05-06

Applicant: Inabata Koryo Kk ,  Nippon Tablet Kk ,  日本タブレット株式会社 ,  稲畑香料株式会社

Inventor： MATSUDA HIDEAKI ,  TONO MASAYUKI ,  FUJITA TAKANORI ,  MATSUMURA SHINICHI ,  YOSHIOKA YURI

IPC: A61K36/18 ,  A23L1/30 ,  A61K8/49 ,  A61K8/97 ,  A61K31/352 ,  A61K36/00 ,  A61P13/08 ,  A61P17/14 ,  A61P19/06 ,  A61P43/00 ,  A61Q7/00 ,  C12N9/99

Abstract: PROBLEM TO BE SOLVED: To prevent or improve gout and hyperuricemia as well as to prevent prostate hypertrophy and male alopecia to improve the QOL (quality of life) of users by compounding an extract and/or dried powder of Kaempferia parviflora into foods and drinks or pharmaceutical products which can be daily ingested, or by compounding into cosmetics to be used, on the basis of the discovery that an extract and/or dried powder of Kaempferia parviflora has a xanthine oxidase inhibition effect and a 5α-reductase inhibition effect.SOLUTION: The xanthine oxidase inhibitor contains an extract and/or dried powder of Kaempferia parviflora.

Abstract translation: 要解决的问题：为了防止或改善痛风和高尿酸血症，以及通过将山楂的提取物和/或干粉混合成食物来预防或改善前列腺肥大和男性脱发来改善使用者的生活质量（生活质量） 以及可以每日摄取的饮料或药物，或通过混合使用的化妆品，基于发现山茶片的提取物和/或干燥粉末具有黄嘌呤氧化酶抑制作用和5α-还原酶抑制作用 。 黄嘌呤氧化酶抑制剂含有山楂叶提取物和/或干粉。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2015010078A

公开(公告)日：2015-01-19

申请号：JP2013138458

申请日：2013-07-01

Applicant: 日本タブレット株式会社 ,  Nippon Tablet Kk ,  公立大学法人大阪府立大学 ,  Osaka Prefecture Univ

Inventor： YAMAJI RYOICHI ,  HAYASHI HIROTAKA ,  FUJITA TAKANORI

IPC: A61K36/18 ,  A61K8/97 ,  A61K31/352 ,  A61K36/00 ,  A61P21/00

Abstract: 【課題】食用可能な天然物由来の新規な筋量増加剤を提供する。【解決手段】本発明の筋量増加剤は、黒ショウガ(Kaempferia parviflora)及び/又は黒ショウガ(Kaempferia parviflora)の抽出物、又は化学式1(但し、R1、R3、R4はいずれも−H又は−OMe、R2は−OHである。)で示されるメトキシフラボン、特に、5-ヒドロキシ-3,7,3',4'-テトラメトキシフラボン、5-ヒドロキシ-7-メトキシフラボン、5-ヒドロキシ-3,7-ジメトキシフラボン、5-ヒドロキシ-3,7,4'-トリメトキシフラボンからなる群から選ばれる1又は2以上の化合物を有効成分とする。【選択図】図2

Abstract translation: 要解决的问题：提供一种从食用天然产物衍生的新型肌肉增重剂。解决方案：本发明的肌肉增重剂含有黑姜（Kaempferia parviflora）和/或黑姜（Kaempferia parviflora）作为活性成分， 提取物或由化学式1表示的甲氧基黄酮（其中，R，R和Rare全部-H或-OMe和Ris -OH），特别是一种或多种选自5-羟基-3， 7,3'，4'-四甲氧基黄酮，5-羟基-7-甲氧基黄酮，5-羟基-3,7-二甲氧基黄酮，5-羟基-3,7,4'-三甲氧基黄酮。

公开(公告)号：JP2013144659A

公开(公告)日：2013-07-25

申请号：JP2012006568

申请日：2012-01-16

Applicant: Nippon Tablet Kk ,  日本タブレット株式会社 ,  Inabata Koryo Kk ,  稲畑香料株式会社

Inventor： MATSUDA HIDEAKI ,  MURATA KAZUYA ,  TONO MASAYUKI ,  FUJITA TAKANORI ,  MATSUMURA SHINICHI ,  YOSHIOKA YURI

IPC: A61K31/352 ,  A23L1/30 ,  A61K8/49 ,  A61P13/08 ,  A61P17/14 ,  A61P43/00 ,  A61Q7/00 ,  C12N9/99

Abstract: PROBLEM TO BE SOLVED: To prevent prostatic hyperplasia and male-pattern alopecia to thereby improve QOL based on a finding that 3,5,7,3',4'-pentamethoxyflavone and 5,7,3',4'-tetramethoxyflavone have 5α-reductase inhibiting action, by compounding the compounds to regularly takable foods, drinks or pharmaceuticals or to cosmetics.SOLUTION: There is provided a 5α-reductase inhibitor containing 5,7,3',4'-tetramethoxyflavone and/or 3,5,7,3',4'-pentamethoxyflavone as active components.

Abstract translation: 要解决的问题：为了防止前列腺增生和男性脱发，从而基于3,5,7,3'，4'-五甲氧基黄酮和5,7,3'，4'-四甲氧基黄酮具有5α的发现来改善生活质量 还原酶抑制作用，通过将化合物与定期可食用的食物，饮料或药物或化妆品混合。解决方案：提供5α-还原酶抑制剂，其含有5,7,3'，4'-四甲氧基黄酮和/或3,5， 7,3'，4'-五甲氧基黄酮作为活性组分。

公开(公告)号：JP2013253047A

公开(公告)日：2013-12-19

申请号：JP2012130266

申请日：2012-06-07

Applicant: UNIV KINKI ,  NIPPON TABLET KK ,  INABATA KORYO CO LTD

Inventor： MATSUDA HIDEAKI ,  MURATA KAZUYA ,  HAYASHI HIROTAKA ,  FUJITA TAKANORI ,  MATSUMURA SHINICHI ,  YOSHIOKA YURI

IPC: A61K31/352 ,  A23L1/30 ,  A61K36/00 ,  A61K36/18 ,  A61P7/00 ,  A61P7/02 ,  A61P9/10 ,  A61P11/00

Abstract: PROBLEM TO BE SOLVED: To provide a hemorheology improving agent useful for prevention/treatment of thrombosis and various diseases relating to thrombosis such as peripheral arteriovenous thrombosis, pulmonary embolism, myocardial infarction, coronary artery occlusion, cerebrovascular occlusion, and retinal arteriovenous thrombosis; and to provide food and drink and pharmaceutical compositions including the hemorheology improving agent.SOLUTION: A hemorheology improving agent includes 3,5,7,3',4'-pentamethoxy flavone represented by formula as an active ingredient. Food and drink and pharmaceutical compositions including the hemorheology improving agent are also provided.