公开(公告)号：JP2003026657A

公开(公告)日：2003-01-29

申请号：JP2002192417

申请日：2002-07-01

申请人： Phanos Development:Kk ,  株式会社ファノスディベロップメント

发明人： KOPIA GREGORY A ,  HORAN PAUL K ,  GRAY BRIAN D ,  TROUTNER DAVID E ,  MUIRHEAD KATHARINE A ,  LIN CHIA-EN ,  SHETH KAMLESHKUMAR A ,  YU ZHIZHOU ,  LEVER SUSAN Z ,  BAIDOO KWAMENA E ,  JENSEN BRUCE D ,  SLEZAK SUE ELLEN

IPC分类号： C07D277/64 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K51/00 ,  A61K51/04 ,  A61K51/08 ,  A61K51/12 ,  C07C235/14 ,  C07D209/10 ,  C07D209/24 ,  C07D219/02 ,  C07D263/56 ,  C07D403/12 ,  C07D495/04 ,  C07K7/06 ,  C07K17/02 ,  C08B37/00 ,  C08B37/10 ,  C09B15/00 ,  C09B23/00

CPC分类号： C08B37/0075 ,  A61K47/6901 ,  A61K51/0453 ,  A61K51/0497 ,  A61K51/08 ,  A61K51/1258 ,  A61K2121/00 ,  A61K2123/00

摘要： PROBLEM TO BE SOLVED: To provide a compound for binding a bio-active substance such as a treating medicine or optionally a diagnostic agent with bio-compatible particles including living cells or viruses, and not-living carrier particles, a composition and a method of the same. SOLUTION: This compound for binding a therapeutically effective substance with lipid-containing bio-particles is characterized by formula (wherein, B is selected from a group consisting of a peptide, an enzyme and an antibody having CO and/or COOH functional groups and capable of binding with a spacer part; R, R1 are each a hydrocarbon substituting group equipped with 1-30 carbon atoms; R2 is a spacer component; X, X1 are same or different and each O, S, C(CH3 )2 or Se; Y is a bonding group selected from =CR8 -, and =CR8 -CR8 = CR8 -, Z is a substituting group selected from H, an alkyl, and OH; the alkyl group constituted by the above Z substituting group has a 1-4C; and further, A is a pharmaceutically permissible anion).

摘要翻译： 要解决的问题：提供用于将生物活性物质如治疗药物或任选的诊断剂与包含活细胞或病毒的生物相容性颗粒和非活性载体颗粒结合的化合物，组合物和方法 一样。 解决方案：用于将治疗有效物质与含脂质生物颗粒结合的化合物的特征在于式（其中，B选自肽，酶和具有CO和/或COOH官能团的抗体，并且能够 与间隔部分结合; R，R1各自为含有1-30个碳原子的烃取代基; R2为间隔基; X，X1相同或不同，O，S，C（CH3）2或Se Y为选自= CR 8 - ，= CR 8 -CR 8 = CR 8 - 的键合基团，Z为选自H，烷基和OH的取代基;由上述Z取代基构成的烷基具有1- 4C;此外，A是药学上可允许的阴离子）。