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公开(公告)号：JPH06145175A
公开(公告)日：1994-05-24
申请号：JP30107092
申请日：1992-11-11
Applicant: SANKYO ORGANIC CHEMICALS CO , SANKYO CO
Inventor： HIRAYAMA MASAO , SAYAMA SHUJI , WATANABE SETSUO , YAMAGUCHI KIYOMI , MIYAMOTO SHIGERU , KATO KEISUKE , SASAO TOMIO , IIJIMA SEISHI
IPC: C07D501/04 , C07D501/18
Abstract: PURPOSE:To efficiently produce the subject derivative of high purity, useful, e.g. as a raw material of cephalosporin-based antibiotics in a high yield without environmental pollution by reacting aminoacetoxymethylcephemcarboxylic acid (salt) under a specified condition. CONSTITUTION:With 7-amino-3-acetoxymethyl-3-cephem-4-carboxylic acid (salt) of formula I, an alkoxylane of formula (R )xSi(OR )4-x (R is R ; x is 0 to 3) or this alkoxylane and a lower alcohol of formula R OH are reacted in the presence of an organic sulfonic acid of formula R SO3H (R is a lower alkyl or an aryl) or a lower alkoxysulfonic acid of formula R OSO3H (R is a lower alkyl). Thereby, the objective 7-amino-3-alkoxymethyl-3-cephem-4-carboxylic acid (salt) of formula II is obtained.
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公开(公告)号：JPH04364188A
公开(公告)日：1992-12-16
申请号：JP29012291
申请日：1991-11-06
Applicant: SANKYO ORGANIC CHEMICALS CO , SANKYO CO
Inventor： HIRAYAMA MASAO , SAYAMA SHUJI , YAMAGUCHI KIYOMI , MIYAMOTO SHIGERU , TAKAHASHI YASUO , KATO KEISUKE , SASAO TOMIO , IIJIMA SEISHI
IPC: C07D501/04 , C07D501/00 , C07D501/18
Abstract: PURPOSE:To obtain the subject high-purity compound having antimicrobial action in high yield by reacting aminoacetoxymethylcefemcarboxylic acid with a lower alkoxysulfonic acid-containing lower alcohol solution and a boric acid tri-lower alkyl, etc. CONSTITUTION:7-Amino-3-acetoxymethyl-3-cefem-4-carboxylic acid shown by formula I or a salt thereof is allowed to react in the presence of a solution of a lowre alkoxysulfonic acid shown by the formula R OSO3H such as methoxysulfonic acid in a lower alcohol (e.g. methyl alcohol) and a tri-lower alkyl borate such as tyrimethyl borate and/or a methylal (e.g. ethylal) shown by the formula CH2(OR )2 to give the objective compound shown by formula II (R is lower alkyl).
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公开(公告)号：JPH08301887A
公开(公告)日：1996-11-19
申请号：JP4584496
申请日：1996-03-04
Applicant: SANKYO CO , SANKYO ORGANIC CHEMICALS CO
Inventor： NAKANO KUNIO , HIRAYAMA MASAO , SAYAMA SHUJI , OHASHI NAOHIKO
Abstract: PURPOSE: To safely and efficiently obtain a compound useful as an intermediate for producing an N-phosphonomethylglycine salt useful as a herbicide, etc., by treating N-phosphonomethyliminodiacetic acid in the presence of water, active carbon and hydrogen peroxide. CONSTITUTION: A method for producing N-phosphonomethylglycine comprises adding water to N-phosphonomethyliminodiacetic acid, adding active carbon to the mixture in an amount of 0.1-0.75 pt.wt. per pt.wt. of the N- phosphonomethyliminodiacetic acid, dropping hydrogen peroxide on the mixture in an amount of 2-5 moles per mole of the N-phosphonomethyliminodiacetic acid with stirring at 60-65 deg.C for 3hr, further aging the mixture for one hr, filtering off the active carbon from the reaction solution at an enhanced temperature, vacuum-concentrating the filtrate to deposit the crystals, and subsequently isolating the crystals, thereby safely and efficiently obtaining the objective N-phosphonomethylglycine useful as a raw material or intermediate for an N-phosphonomethylglycine salt which is widely used as a herbicide.
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公开(公告)号：JPS6139992B2
公开(公告)日：1986-09-06
申请号：JP14684779
申请日：1979-11-13
Applicant: SANKYO ORGANIC CHEMICALS CO
Inventor： MOTOHASHI AKIRA , HIRAYAMA MASAO , MASUDA KAZUO
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公开(公告)号：JPS56161476A
公开(公告)日：1981-12-11
申请号：JP6623080
申请日：1980-05-19
Applicant: SANKYO ORGANIC CHEMICALS CO
Inventor： MOTOHASHI AKIRA , HIRAYAMA MASAO , MASUDA KAZUO , SAYAMA SHIYUUJI
Abstract: PURPOSE:To provide an antifouling paint in which hardening and thickening are improved, by adding a triorganotinamine compd. to an antifouling paint in which a triorganotin polymer type stainproofing agent is used together with cuprous oxide. CONSTITUTION:A triorganotinamine compd. of formula I and/or II [wherein R is lower alkyl, phenyl; R is H, alkyl, phenyl, benzyl, -SnR3 , -R OH; R is alkylene, phenylene, alkylene contg. OH, or a group of formula III (wherein n is 1-10); R is OH] is added to an antifouling paint in which a triorganotin polymer type stainproofing agent having at least one group of the formula -COOSnR3 (wherein R is lower alkyl, phenyl) in the polymer, is used together with cuprous oxide. An example of said triorganotin polymer type stainproofing agent is tripropyltin (meth) acrylate polymer. Examples of said triorganotinamine compds. are those of formulas IV and V.
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Patent Agency Ranking
公开(公告)号：JPS5466954A
公开(公告)日：1979-05-29
申请号：JP13363077
申请日：1977-11-09
Applicant: SANKYO ORGANIC CHEMICALS CO
Inventor： HIRAYAMA MASAO , KIZAKI YOSHIO , KIRIYUU MITSUAKI
Abstract: PURPOSE:Title stabilizer with excellent heat stability and inital coloring properties, that is composed of an organotin mercapto compound and an organoantimony mercapto compound. CONSTITUTION:A tetraorganotin of formula I (R is alkyl, phenyl) is reacted with antimony trihalide of formula II (X is C1, Br, I ) to form a mixture of triorganotin halide and monoorganoantimony halide. The rusulting mixture is reacted with tin tetrahalide of formula III (X' is C1, Br, I). And finally the resluting mixed halides of monoorganotin trihalide, diorganotin dihalide, and monoorganotin trihalide are reacted with an organic compound bearing mercapto groups in the presence of a basic compound to produce the objective stabilizer. To 100 parts by wt of a halogen-containing resin are added 0.1-10, preferably 0.5-5 parts of the resulting stabilizer.
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公开(公告)号：JPS5559160A
公开(公告)日：1980-05-02
申请号：JP13242378
申请日：1978-10-27
Applicant: SANKYO ORGANIC CHEMICALS CO
Inventor： MOTOHASHI AKIRA , HIRAYAMA MASAO , IZAWA MASAO , KISHIHARA NAOO
IPC: C08G59/00 , C07C67/00 , C07C313/00 , C07C319/14 , C07C323/12 , C08G59/14
Abstract: PURPOSE:The reaction of an epoxy compound with an alkali hydrosulfide is conducted in the presence of carbon disulfide and an alcohol, then the reaction mixture is acidified to produce title compound suitably used as resin stabilizer with industrial advantage. CONSTITUTION:In the presence of carbon disulfide and an alcohol preferably of 1-3 carbon atoms, the reaction between (A) an epoxy compound having at least one of epoxy group in the molecule of the formula, and (B) 1mol or more amount, based on per mole of the epoxy compound, of an alkali hydrosulfide as sodium hydrosulfide is effected. Then, the reaction mixture is acidified with hydrochloric acid to produce the objective compound.
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公开(公告)号：JPS54154444A
公开(公告)日：1979-12-05
申请号：JP6294178
申请日：1978-05-26
Applicant: SANKYO ORGANIC CHEMICALS CO
Inventor： ITOU YOSHIO , MOTOHASHI AKIRA , KOUGO YOSHIYUKI , HIRAYAMA MASAO , IHARA HISAJI , ISOMURA HIROMITSU
IPC: C08L27/00 , C08K5/54 , C08K5/548 , C08L1/00 , C08L23/00 , C08L27/04 , C08L33/00 , C08L33/02 , C08L101/00
Abstract: PURPOSE:Title stabilizer that is composed of a silicon compound in which the residue, after the hydrogen is removed from the mercapto group in a mercapto- carboxylic ester, bonds directly with silicon atom, thus being nontoxic and excellent in thermal stabilization effect. CONSTITUTION:A silicon compound, e.g., shown by formula III, in which the residues, after hydrogen is removed from the mercapto group in a mercaptocarboxylic ester of formula I[R is hydrocarbyl; A is phenylene, formula II(X, Y are H, alkyl, aryl, CH2COOR (R is R ); n is 0, 1; m is an integral number of 1 or more], bonds directly with silicon atoms by at least one, preferably 1-4. These stabilizers are synthesized by the reaction between silicon halides and a mercaptocarboxylic ester, when necessary, in the presence of an alcohol.
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公开(公告)号：JPH06306088A
公开(公告)日：1994-11-01
申请号：JP9765393
申请日：1993-04-23
Applicant: SANKYO ORGANIC CHEMICALS CO
Inventor： IIDA MASAHIRO , HIRAYAMA MASAO
IPC: C07F7/22
Abstract: PURPOSE:To safely obtain the compound useful as a synthetic reagent for medicines and other compounds, having low toxicity, usable for reduction reaction, breakage reaction, ring formation reaction, etc., by reducing a specific high-purity tri-n-octyltin lower acylate. CONSTITUTION:An n-octyltin halide composition containing a tri-n-octyltin halide of formula I (X is Cl, Br or I) is treated with an alkali, then subjected to lower acylation to give a high-purity tri-n-octyltin lower acylate of formula II (R is 1-3C lower alkyl) (e.g. tri-n-octyltin acetate), which is reduced by using an alkali metal aluminum hydride (lithium aluminum hydride) or a metal borohydride (e.g. sodium borohydride) to give the objective high-purity compound having low toxicity, usable for reduction reaction, breakage reaction, ring formation reaction, etc., useful for a synthetic reagent for medicines, etc.
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公开(公告)号：JPS56118443A
公开(公告)日：1981-09-17
申请号：JP2202880
申请日：1980-02-22
Applicant: SANKYO ORGANIC CHEMICALS CO
Inventor： MURAYAMA REIJI , ANZAI YOSHIHITO , MASUDA KAZUO , HIRAYAMA MASAO
Abstract: PURPOSE:The titled stabilizer for a resin with excellent effect for heat stability, which comprises a specified sulfur-contg. metal carboxylate and a monoalkyl-tin- contg. sulfur cpd. CONSTITUTION:A stabilizer for a chlorine-contg. resin (e.g., a vinyl chloride resin or a vinylidene chloride resin) is obtd. by mixing (A) at least one selected from sulfur-contg. metal carboxylates of formulas I and II (wherein R1 and R4 are alkyl, hydroxyalkyl, aryl or aralkyl; R and R are H or methyl; M and M are Ba, Ca, Mg or Sr; m and p are 0-1), with (B) a monoalkyltin-contg. suflur cpd. [e.g., formula III or IV (wherein R and R are alkyl; R , R and R are alkyl, alkenyl, aralkyl, cyclohexyl or alkoxyalkyl; q, r and s are 1-2; z, representing degree of polymn, is 1-10), pref. in a wt. ratio of 10:2-1:10.
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