公开(公告)号：JP2002020366A

公开(公告)日：2002-01-23

申请号：JP2000203692

申请日：2000-07-05

申请人： SUMITOMO SEIKA CHEMICALS

发明人： TSUKIJIHARA YUUSAKU ,  IIDA YUKIO

IPC分类号： C07C319/20 ,  C07B61/00 ,  C07C323/56

摘要： PROBLEM TO BE SOLVED: To provide a method for industrially, advantageously producing an alkylthiophenylacetic acid. SOLUTION: This method for producing the objective alkylthiophenylacetic acid of the general formula (3) (wherein, R1 is a 1-4C alkyl) is characterized by comprising hydrolyzing in an aqueous alkaline solution the corresponding alkylthiophenylthioacetamide of the general formula (1) [wherein, R1 is a 1-4C alkyl; R2 and R3 are each H or a 1-4C alkyl, or may be bound to each other together with the adjacent nitrogen atom to form a group of the general formula (2) (wherein, A is CH2 or O)].

公开(公告)号：JP2001302615A

公开(公告)日：2001-10-31

申请号：JP2000117339

申请日：2000-04-19

申请人： SUMITOMO SEIKA CHEMICALS

发明人： TSUKIJIHARA YUUSAKU ,  IIDA YUKIO

IPC分类号： B01J23/04 ,  C07B61/00 ,  C07C319/14 ,  C07C321/30

摘要： PROBLEM TO BE SOLVED: To provide a method for producing bis(phenylthio)benzenes at an industrially low cost and the bis(phenylthio)benzenes without having a thiophenol smell by treating the un-reacted thiophenol in a reaction liquid for no-smelling. SOLUTION: This method for producing the bis(phenylthio)benzenes expressed by the following general formula (3') is characterized by reacting dihalobenzenes expressed by the following general formula (1) (wherein X1, X2 are each independently a halogen atom) with thiophenol expressed by the following formula (2) in an aqueous solution, and the method for producing the bis(phenylthio) bezenes is provided by reacting the un-reacted thiophenol in the reaction liquid after reacting the dihalobenzenes with the thiophenol in the aqueous solution of an alkali metal hydroxide to produce an alkylphenylsulfide derivative for treating the product as not smelling.

公开(公告)号：JPH10168082A

公开(公告)日：1998-06-23

申请号：JP32676896

申请日：1996-12-06

申请人： SUMITOMO SEIKA CHEMICALS

发明人： TSUKIJIHARA YUUSAKU ,  SATAKE SHUZO ,  IIDA YUKIO

IPC分类号： C07B49/00 ,  C07F3/02

摘要： PROBLEM TO BE SOLVED: To readily prepare the subject compound as a Grignard reagent of high purity by allowing a dihalobenzene to react with an alkali metal alkyl mercaptide to effect alkylthiolation, then allowing the alkyl thiolate to react with Mg in the presence of a catalyst. SOLUTION: An dihalobenzene of formula I (X is Cl, Br) (for example, o- dichlorobenzene) is allowed to react with an alkyl mercaptide alkali metal salt of the formula: RSY (R is a 1-8C alkyl group or an alkoxy-substituted 1-8C alkyl; Y is Na, K) (for example, sodium methyl mercaptide) to give an alkylthiohalobenzene of formula II (for example, o-methylthio-chlorobenzene), followed by reaction of the product with magnesium in the presence of a catalyst (for example, 1,2-dibromoethane) in a solvent (for example, tetrahydrofuran) to give the objective compound, a Grignard reagent which is useful as a synthetic starting substance for a variety of medicines, agrochemicals and functional materials.

公开(公告)号：JP2001247563A

公开(公告)日：2001-09-11

申请号：JP2000058387

申请日：2000-03-03

申请人： SUMITOMO SEIKA CHEMICALS

发明人： IIDA YUKIO ,  KATAGIRI TOSHIFUMI ,  TSUKIJIHARA YUUSAKU ,  TAKATORI JUNICHI

IPC分类号： C07D333/38 ,  B01J27/232 ,  B01J31/02 ,  C07B61/00

摘要： PROBLEM TO BE SOLVED: To provide a method for the easy production of a 3-methyl-2- thiophenecarboxylic acids at a low cost. SOLUTION: The 3-methyl-2-thiophenecarboxylic acids expressed by general formula (3) (R1 is H or a 1-8C alkyl) is produced by reacting a 3,4-dihalobutan-2- one expressed by general formula (1) (X1 and X2 are each independently a halogen atom) with a thioglycolic acids expressed by HSCH2COOR1 (R1 is H or a 1-8C alkyl) in the presence of a base.

公开(公告)号：JPH08134043A

公开(公告)日：1996-05-28

申请号：JP26859094

申请日：1994-11-01

申请人： SUMITOMO SEIKA CHEMICALS

发明人： IIDA YUKIO ,  ITSUDA HIROSHI ,  HAYASHIZAKA TOKUYUKI ,  TAKASHIMA NAOKO ,  TSUKIJIHARA YUUSAKU

IPC分类号： C07D233/72

摘要： PURPOSE: To obtain the subject compound useful as a synthetic intermediate for medicines and agrochemicals in high quality and in high selectivity, by reacting a hydantoin in the presence of an alcohol in a solvent by adding chlorine as a single stage reaction in extremely improved operation efficiency without causing a side reaction. CONSTITUTION: This compound of formula II such as 5-methoxy-1- methylhydantoin is obtained by reacting a hydantoin of formula I (R to R are each H, an alkyl, an aryl or an aralkyl; R is a 1-6C alkyl) with (B) an alcohol, preferably a 1-6C alcohol in the presence of (C) one of a chain hydrocarbon, a cyclic hydrocarbon, a halogenated hydrocarbon, an ester and an ether by adding (D) a chlorine. The water content in the reaction system is preferably