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公开(公告)号：JP2010106124A
公开(公告)日：2010-05-13
申请号：JP2008278547
申请日：2008-10-29
CPC分类号： Y02W30/74
摘要： PROBLEM TO BE SOLVED: To provide a process for purifying efficiently and simply glucosylceramide extracted from plants and fungi.
SOLUTION: The process for purifying glucosylceramide extracted from plants and fungi comprises adding water to an extract liquid obtained by extracting from plants and fungi with an organic solvent, and thereafter subjecting the extract liquid to a centrifugal separation to recover a precipitate.
COPYRIGHT: (C)2010,JPO&INPIT摘要翻译： 要解决的问题：提供从植物和真菌中提取的有效和简单的葡糖神经酰胺的纯化方法。 解决方案：从植物和真菌中提取葡萄糖神经酰胺的纯化方法包括向通过有机溶剂从植物和真菌中提取得到的提取液中加入水，然后将提取液进行离心分离以回收沉淀物。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2012180329A
公开(公告)日：2012-09-20
申请号：JP2011045604
申请日：2011-03-02
申请人： Hokkaido Univ , Three-B Co Ltd , 国立大学法人北海道大学 , 株式会社スリービー
IPC分类号： A61K36/07 , A61K31/4172 , A61P31/04 , A61P43/00
CPC分类号： Y02A50/473
摘要： PROBLEM TO BE SOLVED: To provide a promoter for production and secretion of antimicrobial substances in a Paneth cell, which promoter uses extracts from mushrooms and ergothioneine as active constituents.SOLUTION: The promoter for production and/or secretion of antimicrobial substances in a Paneth cell is provided, which promoter uses extracts from mushrooms and/or ergothioneine extracted from the mushrooms as active constituents. The promoter for production and/or secretion of antimicrobial substances uses extracts from edible mushrooms and ergothioneine as active constituents and has high safety. Also, the promoter for production and secretion of antimicrobial substances promotes the production and secretion of antimicrobial substances in a Paneth cell in a living body, so that immunization in the living body can be activated and also diseases can be prevented and treated.
摘要翻译： 要解决的问题：提供Paneth细胞中抗微生物物质的生产和分泌促进剂，该启动子使用蘑菇提取物和麦角硫杆菌素作为活性成分。 解决方案：提供了Paneth细胞中抗微生物物质的生产和/或分泌促进剂，该促进剂使用从蘑菇中提取的来自蘑菇和/或作为活性成分的麦角硫杆菌素的提取物。 抗菌物质的生产和/或分泌促进剂使用食用菌提取物和麦角硫杆菌素作为活性成分，具有较高的安全性。 此外，抗微生物物质的生成和分泌促进剂促进生物体中Paneth细胞中的抗微生物物质的产生和分泌，从而可以活化生物体内的免疫，还可以预防和治疗疾病。 版权所有（C）2012，JPO＆INPIT
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3.发明专利Hypotensive agent containing pentitol or hexitol as active ingredient 有权含有PENTITOL或HEXITOL作为活性成分的HYPOTENSIVE AGENT
公开(公告)号：JP2005306775A
公开(公告)日：2005-11-04
申请号：JP2004125370
申请日：2004-04-21
申请人： Three-B Co Ltd , 株式会社スリービー
发明人： YOSHINARI ATSUSHIRO
摘要： PROBLEM TO BE SOLVED: To obtain a new ACE inhibitor having extremely high safety, and a new hypotensive agent having extremely high safety. SOLUTION: The ACE (angiotensin converting enzyme) inhibitor contains a pentitol or a hexitol as an active ingredient. The most preferable active ingredients are mannitol and xylitol. Also, the ACE inhibitor and the hypotensive agent each contains the extract of Pleurotus comucopiae as an active ingredient. The ACE inhibitor does not has toxicity, does not affect living bodies, even when taken in a large amount, and furthermore has other advantages. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译： 要解决的问题：获得具有极高安全性的新型ACE抑制剂和具有极高安全性的新型降压药。 ACE（血管紧张素转换酶）抑制剂含有戊糖醇或己糖醇作为活性成分。 最优选的活性成分是甘露醇和木糖醇。 此外，ACE抑制剂和降血压药剂各自含有作为活性成分的侧耳属（Pleurotus comucopiae）的提取物。 ACE抑制剂没有毒性，即使大量服用也不影响活体，另外还有其它优点。 版权所有（C）2006，JPO＆NCIPI
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4.发明专利Anti-candida agent and candidiasis-preventing and/or treating agent containing pleurotus cornucopiae extract as active ingredient 有权抗焦虑药剂和甘草酸酯预防和/或治疗包含PLEUROTUS CORNUCOPIAE提取物的药剂作为主动成分
公开(公告)号：JP2012056914A
公开(公告)日：2012-03-22
申请号：JP2010203803
申请日：2010-09-11
发明人： YOSHINARI ATSUSHIRO , ISHIDA MAKI , ABIKO YOSHIHIRO , SATO JUN
IPC分类号： A61K36/07 , A61K31/4164 , A61K31/575 , A61K31/7032 , A61P31/04 , A61P31/10
摘要： PROBLEM TO BE SOLVED: To provide an antifungal agent having excellent antifungal activity such as antiproliferative effects of bacillus and, as derived from Pleurotus cornucopiae of an edible mushroom, so having excellent safety; to provide a β-defensin production promotor capable of promoting, in human being, production of various kinds of human β-defensin; and to provide a candidiasis-preventing and/or treating agent.SOLUTION: The antifungal agent contains one or more substances selected from the group consisting of aqueous solvent extracts of the Pleurotus cornucopiae, glucosylceramide extracted from the Pleurotus cornucopiae, ergothioneine extracted from the Pleurotus cornucopiae, and ergosterol peroxide extracted from the Pleurotus cornucopiae, as active ingredients.
摘要翻译： 要解决的问题：提供具有优良抗真菌活性的抗真菌剂，例如芽孢杆菌的抗增殖作用，以及源于食用蘑菇的白头翁聚宝层，因此具有优异的安全性; 提供能够促进人类生产各种人β-防御素的β-防御素生产促进剂; 并提供阻止念珠菌病和/或治疗剂。 抗真菌剂含有一种或多种选自以下的物质：侧耳聚宝聚糖的水性溶剂提取物，从侧耳聚宝盆提取的葡萄糖神经酰胺，从侧耳聚宝层提取的麦角硫素，和从侧耳聚宝质提取的麦角甾醇， 作为活性成分。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2007308394A
公开(公告)日：2007-11-29
申请号：JP2006137006
申请日：2006-05-16
申请人： Three-B Co Ltd , 株式会社スリービー
发明人： YOSHINARI ATSUSHIRO , KATO KAZUNORI
IPC分类号： A61K36/07 , A61K8/97 , A61K31/715 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/08 , A61P17/16 , A61P37/08 , A61Q19/00
CPC分类号： A61K8/68 , A61K31/715 , A61K36/07 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a new skin-moisturizing agent/dermatitis-therapeutic agent which little produces side effects and can be used for long periods. SOLUTION: This skin-moisturizing agent/dermatitis-therapeutic agent contains a ceramide originated from Tamogi-dake (a mushroom belonging to Pleurotus) as an active ingredient. The ceramide originated from Tamogi-dake has an effect for inhibiting the production of two kinds of chemokine, namely chemokine CCL1 from Langerhans cells, and dermatitis-inducing chemokine CCL27 from surface Keratinocytes. The ceramide originated from the Tamogi-dake exhibits a moisturizing action and a dermatitis onset-inhibiting action in a dermatitis model mouse. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译： 要解决的问题：提供一种新的皮肤保湿剂/皮炎治疗剂，其很少产生副作用并且可以长期使用。 解决方案：该皮肤保湿剂/皮炎治疗剂含有源自Tamogi-dake（属于侧耳属的蘑菇）的神经酰胺作为活性成分。 来自Tamogi-dake的神经酰胺具有抑制两种趋化因子（即来自朗格汉斯细胞的趋化因子CCL1）和来自表面角质形成细胞的诱导诱导趋化因子CCL27的生成的作用。 源自Tamogi-dake的神经酰胺在皮炎模型小鼠中表现出保湿作用和皮炎发作抑制作用。 版权所有（C）2008，JPO＆INPIT
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