公开(公告)号：JPH026751B2

公开(公告)日：1990-02-13

申请号：JP7158180

申请日：1980-05-30

申请人： WELLCOME FOUND

发明人： MAACHIN JOOJI BATSUKUSUTAA ,  ARUBAATO REGINARUDO ERUFUITSUKU ,  ARISUTEAA AINSURII MIRAA ,  DEBITSUDO ARAN SOOYAA

IPC分类号： C07D253/06 ,  A61K31/53 ,  A61P25/08 ,  C07D253/075

公开(公告)号：JPH0144706B2

公开(公告)日：1989-09-29

申请号：JP7158080

申请日：1980-05-30

申请人： WELLCOME FOUND

发明人： MAACHIN JOOJI BATSUKUSUTAA ,  ARUBAATO REGINARUDO ERUFUITSUKU ,  ARISUTEAA AINSURII MIRAA ,  DEBITSUDO ARAN SOOYAA

IPC分类号： C07D253/06 ,  A61K31/53 ,  A61P25/08 ,  A61P25/18 ,  C07C51/15 ,  C07C51/363 ,  C07C51/60 ,  C07C255/61 ,  C07C281/00 ,  C07C281/18 ,  C07D253/075

摘要： The present invention provides compounds of the formula (I) wherein R is chlorine, bromine, iodine, C1-4 alkyl or trifluoromethyl; R is hydrogen, halogen, C1-4 alkyl or trifluoromethyl or R and R form a -CH=CH-CH=CH- group optionally substituted by a halogen atom or a C1-4 alkyl or trifluoromethyl group; R is hydrogen, halogen, C1-4 alkyl or trifluoromethyl; R is hydrogen, halogen, C1-4 alkyl or trifluoromethyl, and R is hydrogen, methyl or fluorine, provided that at most only two of R -R are other than hydrogen and that R -R are not all hydrogen when R is chlorine, which are useful as intermediates for the preparation of compounds of formula (II) wherein R , R , R , R and R are as defined in claim 1 and R is amino, C1-4 acylamino or di-substituted aminomethyleneamino, being useful in the treatment of CNS disorders such epilepsy.

公开(公告)号：JPH0144179B2

公开(公告)日：1989-09-26

申请号：JP12137085

申请日：1985-06-04

申请人： WELLCOME FOUND

发明人： MAACHIN JOOJI BATSUKUSUTAA ,  ARUBAATO REGINARUDO ERUFUITSUKU ,  ARISUTEAA AINSURII MIRAA ,  DEBITSUDO ARAN SOOYAA

IPC分类号： C07D253/06 ,  A61K31/53 ,  A61P25/08 ,  A61P25/18 ,  C07C51/15 ,  C07C51/363 ,  C07C51/60 ,  C07C255/61 ,  C07C281/00 ,  C07C281/18 ,  C07D253/075

摘要： The present invention provides compounds of the formula (I) wherein R is chlorine, bromine, iodine, C1-4 alkyl or trifluoromethyl; R is hydrogen, halogen, C1-4 alkyl or trifluoromethyl or R and R form a -CH=CH-CH=CH- group optionally substituted by a halogen atom or a C1-4 alkyl or trifluoromethyl group; R is hydrogen, halogen, C1-4 alkyl or trifluoromethyl; R is hydrogen, halogen, C1-4 alkyl or trifluoromethyl, and R is hydrogen, methyl or fluorine, provided that at most only two of R -R are other than hydrogen and that R -R are not all hydrogen when R is chlorine, which are useful as intermediates for the preparation of compounds of formula (II) wherein R , R , R , R and R are as defined in claim 1 and R is amino, C1-4 acylamino or di-substituted aminomethyleneamino, being useful in the treatment of CNS disorders such epilepsy.