公开(公告)号：JPH01207267A

公开(公告)日：1989-08-21

申请号：JP5242888

申请日：1988-03-04

Applicant: YAMANOUCHI PHARMA CO LTD

Inventor： IWAMOTO HIDENORI ,  NAGANO KENSHO ,  SATO MASATO ,  KOIDE TOKUO ,  IKADAI HIROYUKI

IPC: C07D211/90 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/445 ,  A61K31/451 ,  A61K31/455 ,  A61P1/16 ,  C07D213/80 ,  C07D405/04

Abstract: NEW MATERIAL:A compound expressed by formula I [R and R are lower alkyl or -A-NR R (A is lower alkylene; R is lower alkyl; R is lower alkyl or aralkyl or R and R together form 5-6-membered ring); R and R are lower alkyl; R and R are H, halogen, lower alkoxy, lower alkoxycarbonyl or nitro; R and R adjacent together form lower alkylenedioxy; the broken line is double bond of resonance structure in the ring or double bond at the 2,3- and 5,6-positions; R is H, lower alkyl, etc.] and salts thereof. EXAMPLE:Dimethyl 4-(2-methoxy-3,4-methylenedioxy)phenyl-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarboxylate. USE:A remedy for hepatopathy. PREPARATION:A compound expressed by formula II is reacted with a compound expressed by formula III in a solvent, such as methanol or DMF, to afford the aimed compound expressed by formula IV, etc.

公开(公告)号：JPH0269459A

公开(公告)日：1990-03-08

申请号：JP22062488

申请日：1988-09-02

Applicant: YAMANOUCHI PHARMA CO LTD

Inventor： IWAMOTO HIDENORI ,  KOIDE TOKUO ,  MATSUHISA AKIRA ,  IKADAI HIROYUKI

IPC: C07D211/90 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61P1/16 ,  C07D213/80

Abstract: NEW MATERIAL:A compound expressed by formula I (R is lower alkyl; R and R are lower alkyl or either thereof is lower alkyl and the other is benzyl, etc.; R is lower alkyl; R and R are lower alkyl or either thereof is lower alkyl and the other is dilower alkylaminoalkyl; n is 2-5; formula II is dihydropyridine or pyridine ring) or salts thereof. EXAMPLE:Methyl 1-(3-dimethylaminoethyl) 4-(4-methoxyphenyl)-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarboxylate. USE:A preventive and treating agent for hepatopathy. PREPARATION:A substituted benzaldehyde is reacted with an acylacetic acid derivative to provide a compound expressed by formula III, which is then reacted with an aminocrotonic acid derivative expressed by formula IV in a solvent, such as ethanol, to afford the compound expressed by formula I.

公开(公告)号：JPH0269475A

公开(公告)日：1990-03-08

申请号：JP22333588

申请日：1988-09-05

Applicant: YAMANOUCHI PHARMA CO LTD

Inventor： IWAMOTO HIDENORI ,  KOIDE TOKUO ,  MATSUHISA AKIRA ,  IKADAI HIROYUKI

IPC: C07D491/056 ,  A61K31/44 ,  A61K31/443 ,  A61K31/495 ,  A61P1/16 ,  C07D405/04 ,  C07D405/14 ,  C07D471/04

Abstract: NEW MATERIAL:The compound of formula I [R and R are lower alkyl or one of R and R is lower alkyl and the other is -A -NR R (A is lower alkylene; R and R are lower alkyl or together form a ring); R and R are lower alkyl or one of R and R is lower alkyl and the other is -A -R (A is lower alkylene; R is di(lower alkyl)amino, etc.); R and R are H, lower alkoxy, etc.; R and R are adjacent to each other and together form a lower alkylenedioxy] and its salt. EXAMPLE:Dimethylaminoethyl methyl 4-[2-(3-methyl)butenyloxycarbonyl-3,4- methylenedioxy-5-methoxy]phenyl-2,6-dimethyl-1,4-dihydropyridine-3,5- dicarboxylate. USE:A preventive and remedy for hepatic diseases. PREPARATION:The compound of formula I can be produced by reacting a compound of formula II with a compound of formula III and, as necessary, oxidizing the product.

公开(公告)号：JPS62153276A

公开(公告)日：1987-07-08

申请号：JP29709585

申请日：1985-12-26

Applicant: YAMANOUCHI PHARMA CO LTD

Inventor： IWAMOTO HIDENORI ,  NISHIKIORI KOJI ,  IKADAI HIROYUKI

IPC: C07D317/00 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/443 ,  A61K31/445 ,  A61K31/535 ,  A61K31/5377 ,  A61P1/16 ,  C07D207/00 ,  C07D249/00 ,  C07D249/14 ,  C07D271/10 ,  C07D285/00 ,  C07D285/12 ,  C07D285/135 ,  C07D405/12 ,  C07D417/12

Abstract: NEW MATERIAL:A nitrogen-containing 5-membered heterocyclic compound shown by formula I [X is O, S or imino; A is lower alkylene; R is group shown by formula II (R and R are H, alkyl or R and R form pyrrolidine, piperidine, morpholine or piperazine wherein nitrogen at the 4-position may be replaced with alkyl) or formula III (R is H or alkyl) or -NHCO-R (R is phenyl or benzodioxolyl)] or its salt. EXAMPLE:2-Amino-5-[(2-piperidinoethyl)thio]-1,3,4-thiadiazole. USE:A preventive and a remedy for hepatic diseases. PREPARATION:A thiol or an alkali metal substituted thiol shown by formula IV (M is H or alkali metal) is reacted with a halide or sulfonate shown by formula V (Y is halogen or organic sulfonic acid residue) to give a compound shown by formula I.

公开(公告)号：JPS6293284A

公开(公告)日：1987-04-28

申请号：JP23426785

申请日：1985-10-19

Applicant: YAMANOUCHI PHARMA CO LTD

Inventor： IWAMOTO HIDENORI ,  TANAKA AKIHIRO ,  NISHIKIORI KOJI ,  IKADAI HIROYUKI

IPC: C07D285/12 ,  A61K31/41 ,  A61K31/433 ,  A61P1/16 ,  C07D285/135

Abstract: NEW MATERIAL:A compound shown by the formula I [X is imino(-NH-), -O- or -S-; R is H, lower alkyl or lower acyl; 1-3 of R -R are lower alkoxy and remaining 0-2 are H; n is 1-5]. EXAMPLE:A 2-amino-5-(4-methoxybenzylthio)-1,3,4-thiadiazole shown by the formula IV. USE:A preventive and remedy for hepatic diseases. PREPARATION:A thiol compound shown by the formula II or a thiolate, its alkykl metal-substituted derivative, is reacted with an alkoxyphenyl lower alkyl-halide or sulfonate shown by the formula III (A is halogen, lower alkylsulfonyloxy or arylsulfonyloxy) usually in a solvent such as DMF, water, etc.

公开(公告)号：JPS6239583A

公开(公告)日：1987-02-20

申请号：JP17966785

申请日：1985-08-14

Applicant: YAMANOUCHI PHARMA CO LTD

Inventor： IWAMOTO HIDENORI ,  TANAKA AKIHIRO ,  NISHIKIORI KOJI ,  IKADAI HIROYUKI

IPC: C07D413/12 ,  A61K31/335 ,  A61K31/357 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/443 ,  A61K31/505 ,  A61P1/16 ,  C07D213/00 ,  C07D233/00 ,  C07D235/00 ,  C07D239/00 ,  C07D249/00 ,  C07D317/00 ,  C07D317/56 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14

Abstract: NEW MATERIAL:A compound expressed by formula I [R is formula II (A and A are C or N; R and R are H, hydroxyl group, lower alkoxy, amino, etc.), formula III (A is O, S or NH), etc.; n is an integer 1-5; R and R are H, hydroxyl group or lower alkoxy] and a salt thereof. EXAMPLE:2-(Piperonylthio)benzodioxazole. USE:A medicine and compound useful for preventing and treating hepatopathy. PREPARATION:A thiol compound expressed by the formula R -SM (M is H or alkali metal) or a thiolate compound which is an alkali metal substitution product thereof is reacted with a (substituted) benzodioxazolyl lower alkyl halide or sulfonate expressed by formula IV (X is halogen or lower alkylsulfonyloxy, etc.) to afford the aimed compound expressed by formula I.