융합된 피라졸 유도체 및 대사 관련 장애의 치료방법에서의 그의 용도
    54.
    发明公开
    융합된 피라졸 유도체 및 대사 관련 장애의 치료방법에서의 그의 용도 无效
    熔化的吡唑衍生物及其在代谢相关疾病治疗方法中的应用

    公开(公告)号:KR1020070088808A

    公开(公告)日:2007-08-29

    申请号:KR1020077016787

    申请日:2005-12-22

    Abstract: The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of E-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

    Abstract translation: 本发明涉及式(Ia)的某些稠合吡唑衍生物及其药学上可接受的盐,其表现出有用的药理学性质,例如作为RUP25受体的激动剂。 本发明还提供含有本发明化合物的药物组合物,以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常,动脉粥样硬化,冠心病,胰岛素抵抗,2型糖尿病 ,综合征-X等。 此外,本发明还提供了本发明化合物与其它活性剂如属于E-葡糖苷酶抑制剂类,醛糖还原酶抑制剂,双胍类,HMG-CoA还原酶抑制剂,角鲨烯合成 抑制剂,贝特类,LDL分解代谢增强剂,血管紧张素转换酶(ACE)抑制剂,胰岛素分泌增强剂,DP受体拮抗剂等。

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