公开(公告)号：KR1020010042637A

公开(公告)日：2001-05-25

申请号：KR1020007011328

申请日：2000-02-14

申请人： 미쯔이카가쿠 가부시기가이샤

发明人： 하야시히데토시 ,  소노다히로시 ,  고토켄이찌 ,  후쿠무라코키 ,  나루세준코 ,  오이카와히데아키 ,  나가타테루유키 ,  시마오카타카시 ,  야스타케츠요시 ,  우메타니히데키 ,  키타시마토시오

IPC分类号： C07B39/00

CPC分类号： C07B39/00 ,  C07C17/202 ,  C07C17/206 ,  C07C41/22 ,  C07C275/06 ,  C07D207/267 ,  C07D231/14 ,  C07D231/16 ,  C07D233/32 ,  C07D239/10 ,  C07D239/30 ,  C07F9/224 ,  C07C22/08 ,  C07C43/225

摘要： A composition comprising hydrogen fluoride and a compound which is liquid in the normal state (25°C, 1 atm), has a boiling point of 120°C or higher, and has a pKa at 25°C of 12 or higher; and use of the composition as a fluorinating agent. The compound is preferably one represented by general formula (1) (wherein R 1 to R 4 may be the same or different and each represents (un)substituted alkyl or aryl, provided that R 1 and R 2 or R 3 and R 4 may be bonded to each other to form a ring containing one or more nitrogen atoms or containing both one or more nitrogen atoms and one or more other heteroatoms, and that R 1 and R 3 may be bonded to each other to form a ring containing one or more nitrogen atoms or containing both one or more nitrogen atoms and one or more other heteroatoms). The fluorinating agent acts by the same reaction mechanism as hydrogen fluoride. When used in the halogen exchange reaction of a halogenated organic compound, the fluorinating agent enables a fluorinated compound to be safely and easily produced without the need of a special apparatus or technique.

摘要翻译： 包含氟化氢和在正常状态（25℃，1atm）下为液体的化合物的组合物的沸点为120℃以上，25℃时的pKa为12以上， 并使用该组合物作为氟化剂。 该化合物优选为通式（1）表示的化合物（其中R 1至R 4可以相同或不同，各自表示（未）取代的烷基或芳基，条件是R 1和R 2或R 3和R 4可以 彼此键合形成含有一个或多个氮原子或含有一个或多个氮原子和一个或多个其它杂原子的环，并且R 1和R 3可以彼此键合以形成含有一个或多个 更多的氮原子或含有一个或多个氮原子和一个或多个其它杂原子）。 氟化剂通过与氟化氢相同的反应机理起作用。 当用于卤代有机化合物的卤素交换反应时，氟化剂使得氟化化合物能够安全和容易地制备，而不需要特殊的装置或技术。

公开(公告)号：KR100382705B1

公开(公告)日：2003-05-09

申请号：KR1020007011328

申请日：2000-02-14

申请人： 미쯔이카가쿠 가부시기가이샤

发明人： 하야시히데토시 ,  소노다히로시 ,  고토켄이찌 ,  후쿠무라코키 ,  나루세준코 ,  오이카와히데아키 ,  나가타테루유키 ,  시마오카타카시 ,  야스타케츠요시 ,  우메타니히데키 ,  키타시마토시오

IPC分类号： C07B39/00

CPC分类号： C07B39/00 ,  C07C17/202 ,  C07C17/206 ,  C07C41/22 ,  C07C275/06 ,  C07D207/267 ,  C07D231/14 ,  C07D231/16 ,  C07D233/32 ,  C07D239/10 ,  C07D239/30 ,  C07F9/224 ,  C07C22/08 ,  C07C43/225

摘要： The invention disclose a hydrogen fluoride containing composition comprising hydrogen fluoride and a compound which is liquid in the standard state (25 DEG C, 1 atmosphere) and has a boiling point of 120 DEG C or more and pka of 12 or more at 25 DEG C, and use of the composition for a fluorination agent. The compound which can be preferably used is represented by the formula (1): wherein R1 to R are a substituted or unsubstituted alkyl or aryl group and can be the same or different, and R1 or R2 or R3 and R4 can bond to form a ring having a nitrogen atom or a nitrogen atom and other hetero atom, or R1 and R3 can bond to form a ring having a nitrogen atom or a nitrogen atom and other hetero atom. The fluorination agent of the invention exerts effect with a similar reaction mechanism to hydrogen fluoride, can be applied to the halogen exchange reaction of a halogen containing organic compound, and can produce a fluorine containing compound with safety and ease without specific equipment or technique.

公开(公告)号：KR100352924B1

公开(公告)日：2002-09-16

申请号：KR1020000033156

申请日：2000-06-16

申请人： 미쯔이카가쿠 가부시기가이샤

发明人： 요시다케이 ,  마쯔오신고 ,  키타시마토시오 ,  토미야칸지 ,  코다카켄지

IPC分类号： C07D231/38

摘要： 하기 식(1)로 표시되는 5-아미노피라졸-4-카르복시산에스테르유도체는, 하기 식(2)로 표시되는 화합물과 하기 식(3)으로 표시되는 히드라진화합물 또는 그의 수화물, 염화수소산염, 브롬화수소산염 혹은 황산염을, 하기 반응식(C):

(식중, R
1 은 할로겐원자로 치환되어 있어도 되는 직사슬 혹은 분기형상의 C1 내지 C4의 알킬기이고, R
2 는 수소원자, 직사슬 혹은 분기형상의 C1 내지 C4의 알킬기 또는 무치환 혹은 치환된 페닐기이고, R
3 은 직사슬 혹은 분기형상의 C1 내지 C4의 알킬기이고, M은 알칼리금속임)에 따라 반응시킴으로써 제조된다.
본 발명의 제조방법에 의해 얻어진 5-아미노피라졸-4-카르복시산에스테르유도체는 농약 및 의약, 특히 살균제의 중간체로서 유용하다.

公开(公告)号：KR1020010049560A

公开(公告)日：2001-06-15

申请号：KR1020000033156

申请日：2000-06-16

申请人： 미쯔이카가쿠 가부시기가이샤

发明人： 요시다케이 ,  마쯔오신고 ,  키타시마토시오 ,  토미야칸지 ,  코다카켄지

IPC分类号： C07D231/38

CPC分类号： C07D231/38

摘要： PURPOSE: Provided are 5-aminopyrazole-4-carboxylate derivative which is an important intermediate of medical products, agricultural chemicals, sterilizing agents and a process for preparing the same. CONSTITUTION: A 5-aminopyrazole-4-carboxylate derivative represented by the formula(1) is prepared by reacting a compound represented by the formula(2) with a hydrazine compound represented by the formula(3) or hydrate, hydrochloride, hydrobromide or sulfate of the same according to the reaction formula(C): wherein R1 is a straight or branched C1 to C4 alkyl group which can be substituted with a halogen atom, R2 is a hydrogen atom, straight or branched C1 to C4 alkyl group or an unsubstituted or substituted phenyl group, and R3 is a straight or branched C1 to C4 alkyl group, and M is an alkali metal. The 5-aminopyrazole-4-carboxylate derivative obtained by the preparation process of the invention is useful for an intermediate of agricultural chemicals and medicines, fungicides in particular.

摘要翻译： 目的：提供作为医药产品，农药，灭菌剂的重要中间体的5-氨基吡唑-4-羧酸酯衍生物及其制备方法。 构成：由式（1）表示的5-氨基吡唑-4-羧酸酯衍生物通过使由式（2）表示的化合物与式（3）表示的肼化合物或水合物，盐酸盐，氢溴酸盐或硫酸盐 根据反应式（C）：其中R1是可以被卤素原子取代的直链或支链C1-C4烷基，R2是氢原子，直链或支链C1-C4烷基或未取代的 或取代的苯基，并且R 3是直链或支链的C 1至C 4烷基，M是碱金属。 通过本发明的制备方法获得的5-氨基吡唑-4-羧酸酯衍生物可用于农药和药物的中间体，特别是杀真菌剂。