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公开(公告)号：KR101880585B1
公开(公告)日：2018-07-23
申请号：KR1020170035969
申请日：2017-03-22
Applicant: 서울대학교산학협력단 , 한림대학교 산학협력단
IPC: A61M1/28
CPC classification number: A61M1/28 , A61M1/285 , A61M2205/3344 , A61M2205/35
Abstract: 본발명은복막투석액삼투압조절장치에관한것으로, 상기구성에의해삼투압조성물질인포도당혹은녹말유래당중합체등을복막투석액과는별도로지속적으로주입할수 있는휴대형장치로, 복막투석액의복막내 저류시간중 삼투압을일정하게유지하거나필요한만큼조절할수 있게하는복막투석액삼투압조절장치에관한것이다.
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2.发明公开
公开(公告)号：KR1020110040371A
公开(公告)日：2011-04-20
申请号：KR1020090097602
申请日：2009-10-14
Applicant: 한림대학교 산학협력단
CPC classification number: Y02A50/411
Abstract: PURPOSE: A Vaccinium uliginosum L. extract which enhances intracellular introducing ability of SOD fusion protein is provided to enhance intracellular activity and to treat various diseases. CONSTITUTION: A Vaccinium uliginosum L. extract enhances cell permeability of cell permeable superoxide dismutase fusion protein. The Vaccinium uliginosum L. extract is an anthocyanin fraction. A protein transport domain is an HIV-1 Tat(49-57), Tat(51-57), Tat(50-56), Tat(50-57), Tat(50-55), oligo arginine having 5-12 arginine residues, oligolysine having 5-12 lysine residues, or 5-12 arginine. A pharmaceutical composition which is useful for SOD-dependent diseases contains a cell permeable SOD fusion protein and pharmaceutically acceptable carrier containing Vaccinium uliginosum L. extract.
Abstract translation: 目的：提供增强SOD融合蛋白的细胞内引入能力的牛痘提取物，以增强细胞内活性和治疗各种疾病。 构成：牛痘提取物增强细胞渗透性超氧化物歧化酶融合蛋白的细胞渗透性。 牛痘提取物是花青素组分。 蛋白质转运结构域是HIV-1 Tat（49-57），Tat（51-57），Tat（50-56），Tat（50-57），Tat（50-55），具有5-12个 精氨酸残基，具有5-12赖氨酸残基的寡聚赖氨酸或5-12精氨酸。 可用于SOD依赖性疾病的药物组合物含有细胞可渗透SOD融合蛋白和含有牛痘提取物的药学上可接受的载体。
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公开(公告)号：KR101090749B1
公开(公告)日：2011-12-08
申请号：KR1020090097602
申请日：2009-10-14
Applicant: 한림대학교 산학협력단
CPC classification number: Y02A50/411
Abstract: 본발명은재조합이나화학적결합방법으로단백질수송도메인과결합된슈퍼옥사이드디스뮤테이즈(SOD) 융합단백질에들쭉추출물을가함으로써이 융합단백질의세포내도입능력을증가시키는방법을제공한다.
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