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    혼합 모드 리간드
    3.
    发明公开
    혼합 모드 리간드 有权
    混合模式配置

    公开(公告)号：KR1020130014039A

    公开(公告)日：2013-02-06

    申请号：KR1020120082764

    申请日：2012-07-27

    Applicant: 폴 코포레이션

    Inventor： 아이트-아두아산 ,  온예마우와프랭크 ,  하이조나단 ,  노춤손사무엘

    IPC: B01J20/286 ,  C07C233/07 ,  C07C321/20 ,  B01D15/08

    CPC classification number: B01J20/3248 ,  B01D15/166 ,  B01D15/3847 ,  B01J20/24 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3285 ,  C07K1/165 ,  Y02P20/582

    Abstract: PURPOSE: A mixed mode ligand is provided to connect a solid support to a ligand with a covalent bond and to comprise a linker with at least one C, O, N, or S atom by providing a substrate with the solid supporter, the ligand, and the linker. CONSTITUTION: A mixed mode ligand comprises a solid supporter, a ligand, and a linker. The ligand is indicated with a chemical formula, the linker comprises at least one of a C, O, N, or S atom. The linker connects the solid supporter to the ligand by a covalent bond by locating at the wave line indication on the upper part of the ligand. [Reference numerals] (AA) Ligand DBC for ligand density vs. IgG; (BB) Ligand density(umol); (CC) Ligand DBC(mg/ml); (DD) Ligand density and DBC; (EE) Resin

    Abstract translation: 目的：提供混合模式配体以将固体支持物与配体与共价键连接，并且通过提供具有固体支持物的底物，配体，配体，以及包含具有至少一个C，O，N或S原子的连接体， 和接头。 构成：混合模式配体包含固体支持体，配体和接头。 配体用化学式表示，连接体包括C，O，N或S原子中的至少一个。 通过定位在配体上部的波线指示，该接头通过共价键将固体支持体连接到配体上。 （AA）配体浓度对IgG的配体DBC; （BB）配体密度（umol）; （CC）配体DBC（mg / ml）; （DD）配体密度和DBC; （EE）树脂

    단백질 분리 방법
    4.
    发明公开
    단백질 분리 방법 无效
    蛋白质分离过程

    公开(公告)号：KR1020070091098A

    公开(公告)日：2007-09-07

    申请号：KR1020077000516

    申请日：2005-06-06

    Applicant: 에이브이티 플라즈마 리미티드

    Inventor： 리메알란

    IPC: C07K1/14

    CPC classification number: B01J20/28011 ,  B01D15/3804 ,  B01D15/426 ,  B01J20/28004 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3242 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/765 ,  C07K14/78 ,  C07K14/81

    Abstract: In one aspect, the present invention is directed to a process for isolating proteins from a solution comprising proteins, wherein the solution is selected from the group consisting of: crude bood plasma, blood serum, cryosupernatant derived from plasma, fractionated human plasma, cryoprecipitate derived from plasma and recombinant broths. The process involves providing a solid separation medium having the formula: M-S-L wherein M is a matrix backbone, S is an optional spacer arm, and L is a ligand which is mercaptonicotinic acid, contacting the solid separation medium with the solution comprising the proteins, such that at least one of the proteins becomes reversibly bound bound to said solid separation medium. At least one elution step is then performed to selectively elute at least one protein fraction from the solid separation medium. In another aspect, the present invention is directed to a process for isolating Factor VIII and/or Factor IX.

    Abstract translation: 一方面，本发明涉及从包含蛋白质的溶液中分离蛋白质的方法，其中所述溶液选自：粗制血浆，血清，源自血浆的冷冻上清液，分级人血浆，衍生的冷沉淀物 来自血浆和重组肉汤。 该方法包括提供具有下式的固体分离介质：MSL其中M是基质骨架，S是可选的间隔臂，L是巯基烟酸配体，使固体分离培养基与包含蛋白质的溶液接触， 至少一种蛋白质变得可逆地结合到所述固体分离培养基上。 然后进行至少一个洗脱步骤以从固体分离介质中选择性洗脱至少一种蛋白质级分。 另一方面，本发明涉及一种分离因子VIII和/或因子IX的方法。

    돌연변이된 이뮤노글로불린-결합 폴리펩티드
    7.
    发明公开
    돌연변이된 이뮤노글로불린-결합 폴리펩티드 审中-实审
    突变的免疫球蛋白结合多肽

    公开(公告)号：KR1020170078693A

    公开(公告)日：2017-07-07

    申请号：KR1020177012873

    申请日：2015-11-16

    Applicant: 지이 헬스케어 바이오프로세서 알&디 에이비

    Inventor： 로드리고구스타프 ,  뵈르크만토마스 ,  안데르매츠

    IPC: C07K14/31 ,  C07K16/06 ,  C07K1/22 ,  B01D15/38 ,  B01J20/289 ,  B01J20/32

    CPC classification number: C07K14/31 ,  B01D15/3809 ,  B01J20/289 ,  B01J20/3219 ,  B01J20/3274 ,  C07K1/22 ,  C07K16/00 ,  C07K16/065

    Abstract: 본발명은적어도서열식별번호: 4-7의위치 11에해당하는위치의아스파라긴또는세린잔기가글루탐산, 리신, 티로신, 트레오닌, 페닐알라닌, 류신, 이소류신, 트립토판, 메티오닌, 발린, 알라닌, 히스티딘및 아르기닌으로이루어진군에서선택되는아미노산으로돌연변이되어있는, 서열식별번호: 1, 서열식별번호: 2, 서열식별번호: 3, 서열식별번호: 4, 서열식별번호: 5, 서열식별번호: 6, 서열식별번호: 7, 서열식별번호: 22, 서열식별번호: 51 또는서열식별번호: 52에의해정의되는바와같은스태필로코쿠스단백질 A (SpA) Fc-결합도메인의돌연변이를포함하는향상된알칼리안정성의 Fc-결합폴리펩티드에관한것이다.

    Abstract translation: 本发明，至少在SEQ ID NO：在对应于位置4-7 11谷氨酸，赖氨酸，酪氨酸，苏氨酸，苯丙氨酸，亮氨酸，异亮氨酸，色氨酸，蛋氨酸，缬氨酸，丙氨酸，组氨酸和精氨酸位天冬酰胺或丝氨酸残基 该突变于SEQ ID NO选自下组，所选的酸：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO：6，SEQ ID号 ：7，SEQ ID NO：22，SEQ ID NO：51或SEQ ID NO：由鼻子52楠蛋白A（SPA）中所定义的稳定枕于Fc的结合结构域增加含Fc的突变的碱稳定性 结合多肽。

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