公开(公告)号：US5476445A

公开(公告)日：1995-12-19

申请号：US283961

申请日：1994-08-01

申请人： George Baerveldt ,  Larry W. Blake

发明人： George Baerveldt ,  Larry W. Blake

IPC分类号： A61F9/007 ,  A61M27/00 ,  A61M5/00

CPC分类号： A61F9/00781 ,  A61M27/002

摘要： An implant for use in the treatment of glaucoma is disclosed wherein the implant comprises an elastomeric plate having a non-valved elastomeric drainage tube attached thereto. The plate is curved so as to conform to the spherical anatomy of the eyeball. An annular sloped wall extends from the plate and surrounds the opening of the drainage tube into the plate. The plate is inserted beneath Tenon's capsule and sutured to the sclera utilizing temporary and non-dissolving permanent sutures. The annular wall provides a temporary sealing surface against the sclera. The drainage tube is tunnelled through the sclera and cornea and inserted into the anterior chamber, thus providing fluid communication between the anterior chamber and the elastomeric plate. The annular wall around the tube forms a temporary seal which restricts the drainage of aqueous fluid until formation of the bleb is completed. After bleb formation occurs, the temporary sutures around the wall are removed or dissolve. Once the temporary sutures are gone, the portion of the plate that is not stitched to the sclera floats within the bleb and breaks the seal between the implant and the sclera. Once the seal is broken, unrestricted flow between the anterior chamber and bleb is maintained.

摘要翻译： 公开了一种用于治疗青光眼的植入物，其中所述植入物包括具有连接到其上的非瓣膜弹性体引流管的弹性体板。 该板是弯曲的，以符合眼球的球形解剖结构。 环形斜壁从板延伸并且将排水管的开口包围到板中。 将板插入Tenon's胶囊下方，并使用临时和不溶解的永久性缝合线缝合至巩膜。 环形壁提供抵抗巩膜的临时密封表面。 引流管通过巩膜和角膜隧道并插入前房，从而在前房和弹性体板之间提供流体连通。 管周围的环形壁形成临时密封，其限制水性流体的排出，直到完成泡沫的形成。 在发生气泡形成之后，围绕壁的临时缝合线被去除或溶解。 一旦临时缝线消失，板上没有缝合到巩膜的部分在泡泡内漂浮，并破坏植入物和巩膜之间的密封。 一旦密封破裂，保持前房和泡沫之间的不受限制的流动。

公开(公告)号：US5589024A

公开(公告)日：1996-12-31

申请号：US464217

申请日：1995-06-05

申请人： Larry W. Blake

发明人： Larry W. Blake

IPC分类号： A61F2/16 ,  B29C33/00 ,  B29C33/38 ,  B29C33/76 ,  B29D11/00 ,  B29D11/02 ,  B32B31/12

CPC分类号： B29D11/00971 ,  A61F2/1613 ,  B24B13/0006 ,  B29C33/0033 ,  B29C33/3842 ,  B29C33/76 ,  B29D11/00038 ,  B29D11/023 ,  A61F2002/1686 ,  Y10S623/901

摘要： A lens, having an optical power surface, which may have multiple radii portions or aspherical portions as well as spherical portions, is molded in a coined mold. A pair of core pins, positioned within the mold cavity during the lens forming process, will produce a pair of haptic-mounting holes within the lens. As the lenses are subsequently tumbled to remove flash, indentations will form adjacent to the haptic-mounting holes. These indentations allow for tangential attachment of the haptic to the lens which, in turn, enables maximum flexibility without exceeding the width of the optic.

摘要翻译： 具有光学功率表面的透镜，其可以具有多个半部分或非球面部分以及球形部分，在模制的模具中被模制。 在透镜成形过程中位于模腔内的一对芯柱将在透镜内产生一对触觉安装孔。 随着镜片随后翻滚以去除闪光，凹痕将在触觉安装孔附近形成。 这些凹痕允许触觉件相对于透镜的切向附接，这又能够实现最大的灵活性而不超过光学元件的宽度。

公开(公告)号：US5178604A

公开(公告)日：1993-01-12

申请号：US531010

申请日：1990-05-31

申请人： George Baerveldt ,  Larry W. Blake ,  George M. Wright

发明人： George Baerveldt ,  Larry W. Blake ,  George M. Wright

IPC分类号： A61F9/00 ,  A61F9/007 ,  A61M1/00 ,  A61M27/00

CPC分类号： A61M27/002 ,  A61F9/00781

摘要： An implant for use in the treatment of glaucoma is disclosed wherein the implant comprises an elastomeric plate having a non-valved elastomeric drainage tube attached thereto. The plate is elliptical in shape and curved so as to conform to the curvature of the eye. The plate is inserted into the eye in an incision made in the Tenon's capsule and sutured to the sclera. The drainage tube is tunnelled through the Tenon's capsule and cornea and inserted into the anterior chamber, thus providing patent fluid communication between the anterior chamber and the elastomeric plate. The flexible structure of the plate allows the plate to be easily inserted, thus reducing the surgical procedure length. In addition, the pliable material minimizes th risk of damage and trauma to surrounding tissues in the insertion process.

摘要翻译： 公开了一种用于治疗青光眼的植入物，其中所述植入物包括具有连接到其上的非瓣膜弹性体引流管的弹性体板。 该板的形状为椭圆形并弯曲，以符合眼睛的曲率。 将板插入到Tenon胶囊中的切口中并缝合到巩膜上。 引流管穿过Tenon的胶囊和角膜，并插入前房，从而在前房和弹性体板之间提供专利流体连通。 板的柔性结构允许板容易地插入，从而减少手术过程长度。 此外，柔韧材料可以最大限度地减少插入过程中周围组织的损伤和创伤风险。

公开(公告)号：US5772667A

公开(公告)日：1998-06-30

申请号：US749947

申请日：1996-11-14

申请人： Larry W. Blake

发明人： Larry W. Blake

IPC分类号： A61F2/16 ,  A61B17/00

CPC分类号： A61F2/1662

摘要： An intraocular lens injector compresses an intraocular lens by rolling the lens into a tight spiral and injects the compressed lens though a relatively small incision in the eye, approximately 2-3 millimeters in length, resulting from a phacoemulsification procedure. The intraocular lens is inserted into a receiving channel of the injector in an uncompressed state and is urged into a cylindrical passageway. As the intraocular lens advances into the cylindrical passageway, the lens will roll upon itself into a tightly rolled spiral within the confines of the cylindrical passageway. An insertion rod is inserted into an open end of the cylindrical passageway and advances the compressed lens down the passageway. As the lens exits the passageway and enters the eye, the lens will expand back to its uncompressed state.

摘要翻译： 眼内透镜注射器通过将透镜滚动成紧密的螺旋来压缩眼内透镜，并通过晶状体乳化过程产生约2-3毫米长的眼睛中的相对小的切口注射经压缩的透镜。 眼内透镜以未压缩状态插入注射器的接收通道中，并被推入圆柱形通道中。 当眼内透镜进入圆柱形通道时，透镜将在圆柱形通道的范围内自身滚动成紧密卷绕的螺旋。 插入杆插入圆柱形通道的开口端，并将压缩透镜向下通过通道。 当镜头离开通道并进入眼睛时，镜头将扩展回未压缩状态。

公开(公告)号：US5507806A

公开(公告)日：1996-04-16

申请号：US242130

申请日：1994-05-13

申请人： Larry W. Blake

发明人： Larry W. Blake

IPC分类号： A61F2/16

CPC分类号： A61F2/1618 ,  A61F2/1648 ,  A61F2002/1689

摘要： An improved multi-faceted intraocular lens with a main optical element having a plurality of optical elements. The flexible, thin multi-faceted intraocular lens is made of an optical-grade soft biocompatible material, such as a flexible acrylic material, a hydrophilic material, or a silicone material. The thin, flat, multi-faceted intraocular lens may enable implantation of the lens through an intraocular lens injector having an injection tube with a diameter of approximately 1 mm to 4 mm. The plurality of optical elements each may have the same or differing diopter powers. Additionally, the plurality of optical elements may be aligned to form a multi-focal lens. Further, the optical elements each may be selected from a group consisting of toric elements, aspheric elements, and spherical elements depending upon the type of correction desired. Lastly, the multi-faceted intraocular lens may be effective in the treatment of age-related macular degeneration.

摘要翻译： 一种改进的具有多个光学元件的主光学元件的多面眼内透镜。 柔性薄薄的多面眼内透镜由光学级软生物相容性材料制成，例如柔性丙烯酸材料，亲水材料或硅树脂材料。 薄的，平坦的，多面的眼内透镜可以使镜片能够通过具有直径约1mm至4mm的注射管的眼内透镜注射器植入。 多个光学元件各自可以具有相同或不同的屈光度。 另外，多个光学元件可以对准以形成多焦点透镜。 此外，根据期望的校正类型，光学元件各自可以选自由复曲面元件，非球面元件和球形元件组成的组。 最后，多方位眼内晶状体可有效治疗年龄相关性黄斑变性。

公开(公告)号：US5674435A

公开(公告)日：1997-10-07

申请号：US464104

申请日：1995-06-05

申请人： Larry W. Blake

发明人： Larry W. Blake

IPC分类号： A61F2/16 ,  B29C33/00 ,  B29C33/38 ,  B29C33/76 ,  B29D11/00 ,  B29D11/02

CPC分类号： B29D11/00971 ,  A61F2/1613 ,  B24B13/0006 ,  B29C33/0033 ,  B29C33/3842 ,  B29C33/76 ,  B29D11/00038 ,  B29D11/023 ,  A61F2002/1686 ,  Y10S623/901

摘要： A lens, having an optical power surface, which may have multiple radii portions or aspherical portions as well as spherical portions, is molded in a coined mold. A pair of core pins, positioned within the mold cavity during the lens forming process, will produce a pair of haptic-mounting holes within the lens. As the lenses are subsequently tumbled to remove flash, indentations will form adjacent to the haptic-mounting holes. These indentations allow for tangential attachment of the haptic to the lens which, in turn, enables maximum flexibility without exceeding the width of the optic.

摘要翻译： 具有光学功率表面的透镜，其可以具有多个半部分或非球面部分以及球形部分，在模制的模具中被模制。 在透镜成形过程中位于模腔内的一对芯柱将在透镜内产生一对触觉安装孔。 随着镜片随后翻滚以去除闪光，凹痕将在触觉安装孔附近形成。 这些凹痕允许触觉件相对于透镜的切向附接，这又能够实现最大的灵活性而不超过光学元件的宽度。

公开(公告)号：US5558629A

公开(公告)日：1996-09-24

申请号：US917575

申请日：1992-07-21

申请人： George Baerveldt ,  Larry W. Blake ,  George M. Wright

发明人： George Baerveldt ,  Larry W. Blake ,  George M. Wright

IPC分类号： A61F9/00 ,  A61F9/007 ,  A61M1/00 ,  A61M27/00

CPC分类号： A61M27/002 ,  A61F9/00781

摘要： An implant for use in the treatment of glaucoma is disclosed wherein the implant comprises an elastomeric plate having a non-valved elastomeric drainage tube attached thereto. The plate is elliptical in-shape and curved so as to conform to the curvature of the eye. The plate is inserted into the eye in an incision made in the Tenon's capsule and sutured to the sclera. The drainage tube is tunnelled through the Tenon's capsule and cornea and inserted into the anterior chamber, thus providing patent fluid communication between the anterior chamber and the elastomeric plate. The flexible structure of the plate allows the plate to be easily inserted, thus reducing the surgical procedure length. In addition, the pliable material minimizes the risk of damage and trauma to surrounding tissues in the insertion process.

摘要翻译： 公开了一种用于治疗青光眼的植入物，其中所述植入物包括具有连接到其上的非瓣膜弹性体引流管的弹性体板。 该板是椭圆形和弯曲的，以符合眼睛的曲率。 将板插入到Tenon胶囊中的切口中并缝合到巩膜上。 引流管穿过Tenon的胶囊和角膜，并插入前房，从而在前房和弹性体板之间提供专利流体连通。 板的柔性结构允许板容易地插入，从而减少手术过程长度。 此外，柔韧材料可以最大限度地减少插入过程中损伤周围组织的风险。

公开(公告)号：US5468246A

公开(公告)日：1995-11-21

申请号：US86930

申请日：1993-07-02

申请人： Larry W. Blake

发明人： Larry W. Blake

IPC分类号： A61F2/16 ,  A61B17/00

CPC分类号： A61F2/1662

摘要： An intraocular lens injector compresses an intraocular lens by rolling the lens into a tight spiral and injects the compressed lens though a relatively small incision in the eye, approximately 2-3 millimeters in length, resulting from a phacoemulsification procedure. The intraocular lens is inserted into a receiving channel of the injector in an uncompressed state and is urged into a cylindrical passageway. As the intraocular lens advances into the cylindrical passageway, the lens will roll upon itself into a tightly rolled spiral within the confines of the cylindrical passageway. An insertion rod is inserted into an open end of the cylindrical passageway and advances the compressed lens down the passageway. As the lens exits the passageway and enters the eye, the lens will expand back to its uncompressed state.

摘要翻译： 眼内透镜注射器通过将透镜滚动成紧密的螺旋来压缩眼内透镜，并通过晶状体乳化过程产生约2-3毫米长的眼睛中的相对小的切口注射经压缩的透镜。 眼内透镜以未压缩状态插入注射器的接收通道中，并被推入圆柱形通道中。 当眼内透镜进入圆柱形通道时，透镜将在圆柱形通道的范围内自身滚动成紧密卷绕的螺旋。 插入杆插入圆柱形通道的开口端，并将压缩透镜向下通过通道。 当镜头离开通道并进入眼睛时，镜头将扩展回未压缩状态。

公开(公告)号：US5185107A

公开(公告)日：1993-02-09

申请号：US705771

申请日：1991-05-28

申请人： Larry W. Blake

发明人： Larry W. Blake

IPC分类号： A61F2/16 ,  B29C33/00 ,  B29C33/38 ,  B29C33/76 ,  B29D11/00 ,  B29D11/02

CPC分类号： B29D11/00971 ,  A61F2/1613 ,  B24B13/0006 ,  B29C33/0033 ,  B29C33/3842 ,  B29C33/76 ,  B29D11/00038 ,  B29D11/023 ,  A61F2002/1686 ,  Y10S623/901

摘要： A lens, having an optical power surface, which may have multiple radii portions or aspherical portions as well as spherical portions, is molded in a coined mold. A pair of core pins, positioned within the mold cavity during the lens forming process, will produce a pair of haptic-mounting holes within the lens. As the lenses are subsequently tumbled to remove flash, indentations will form adjacent to the haptic-mounting holes. These indentations allow for tangential attachment of the haptic to the lens which, in turn, enables maximum flexibility without exceeding the width of the optic.

摘要翻译： 具有光学功率表面的透镜，其可以具有多个半部分或非球面部分以及球形部分，在模制的模具中被模制。 在透镜成形过程中位于模腔内的一对芯柱将在透镜内产生一对触觉安装孔。 随着镜片随后翻滚以去除闪光，凹痕将在触觉安装孔附近形成。 这些凹痕允许触觉件相对于透镜的切向附接，这又能够实现最大的灵活性而不超过光学元件的宽度。

公开(公告)号：US5717049A

公开(公告)日：1998-02-10

申请号：US622527

申请日：1996-03-25

申请人： Xiugao Liao ,  Yading Wang ,  Stephen Q. Zhou

发明人： Xiugao Liao ,  Yading Wang ,  Stephen Q. Zhou

IPC分类号： A61L27/00 ,  A61F2/16 ,  C07C231/02 ,  C07C233/09 ,  C08F20/54 ,  C08F20/56 ,  C08F120/54 ,  C08F220/56 ,  C08F20/58

CPC分类号： A61F2/1616 ,  C07C233/09 ,  C08F20/54 ,  Y10S623/924

摘要： Novel biocompatible, high strength hydrogels useful in intraocular lenses are provided which are optically transparent, have high refractive indices and possess long term stability. The hydrogels are prepared from cross-linked copolymers of N-benzyl-N-methylacrylamide.

摘要翻译： 提供了可用于眼内透镜的新型生物相容性高强度水凝胶，其是光学透明的，具有高折射率并具有长期稳定性。 水凝胶由N-苄基-N-甲基丙烯酰胺的交联共聚物制备。