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    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
    4.
    发明申请
    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 有权
    包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法

    公开(公告)号：US20020137814A1

    公开(公告)日：2002-09-26

    申请号：US10011570

    申请日：2001-12-04

    发明人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-Quan Mao ,  Kam W. Leong

    IPC分类号： C08K003/00 ,  A61K039/395 ,  A61K039/38 ,  C08G079/02

    CPC分类号： C08G79/04 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: 1 wherein: each of R and Rnull is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; Rnull is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, Rnull or Rnull is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

    摘要翻译： 描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L是二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; 并且n为5至1,000，其中所述可生物降解聚合物在生物降解之前和之后是生物相容的。 在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。 还描述了除了聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法。

    Medication device with protein stabilizing surface coating
    6.
    发明申请
    Medication device with protein stabilizing surface coating 有权
    具有蛋白质稳定表面涂层的药物装置

    公开(公告)号：US20010051277A1

    公开(公告)日：2001-12-13

    申请号：US09876569

    申请日：2001-06-06

    申请人： MiniMed, Inc.

    发明人： William Peter Van Antwerp ,  Poonam S. Gulati ,  Gerald E. Adomian

    IPC分类号： H05H001/24 ,  B05D003/00 ,  A61L002/00 ,  B32B015/04 ,  B32B027/00

    CPC分类号： A61M5/14276 ,  A61L29/085 ,  A61L31/10 ,  A61L33/06 ,  Y10S623/924 ,  Y10T428/31678 ,  Y10T428/31855 ,  C08L75/04

    摘要： The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medications. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such treated surfaces including the covalent attachment of hydrophilic surfactants.

    摘要翻译： 本发明提供了诸如药物输注泵的医疗装置，其具有被处理以抑制蛋白质变性的内表面。 根据本发明，提供亲水内表面和相关的涂覆方法以减少或消除当处理复杂的基于蛋白质的药物时可能发生的药物沉积物的积累。 优选的亲水泵表面包括表现出非常低的蛋白质吸附特性的亲水性表面活性剂（PEO）或（PEG）涂层。 公开了几种用于生产这样的处理表面的方法，包括亲水性表面活性剂的共价连接。

    Collagen material and its production process
    7.
    发明申请
    Collagen material and its production process 有权
    胶原材料及其生产工艺

    公开(公告)号：US20010016205A1

    公开(公告)日：2001-08-23

    申请号：US09761593

    申请日：2001-01-16

    申请人： Yasuhiko SHIMIZU

    发明人： Yasuhiko Shimizu

    IPC分类号： B32B005/02 ,  B32B027/04 ,  B32B027/12

    CPC分类号： C08L89/06 ,  A61F2310/00365 ,  A61L27/24 ,  A61L31/044 ,  Y10S128/08 ,  Y10S623/909 ,  Y10S623/924 ,  Y10S623/925 ,  Y10T442/2525

    摘要： The present invention relates to a collagen material comprising a laminate in which a collagen ultra-fine fibrous non-woven fabric-like multi-layer structure is sandwiched between non-fibrous collagen layers, a thread-like material containing said collagen material, their production processes, and a medical material containing said collagen material, and particularly a medical alternative membrane comprised of said medical material. These use collagen for their raw material without combining the use of a synthetic polymer material, possess physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and the alternative medical membrane can be used as a material for filling in the missing portions of biomembranes such as endocranium, pericardium, pleura, peritonium or serous membrane, presents no ethical problems, is in stable supply, has no risk of infection, does not cause cell degeneration, allows control of the rate of degradation following application to the body, and has an action that promotes regeneration of biomembranes.

    摘要翻译： 本发明涉及一种胶原材料，其包括层压体，其中胶原超细纤维无纺布状多层结构夹在非纤维胶原层之间，含有所述胶原材料的线状材料，其生产 方法和含有所述胶原材料的医疗材料，特别是包含所述医疗材料的医疗替代膜。 这些使用胶原蛋白作为其原料而不合并使用合成聚合物材料，具有允许缝合同时仍维持胶原固有的生物化学性质的程度的物理性质，并且替代医用膜可用作填充材料 在生物膜如颅内膜，心包膜，胸膜，胸膜或浆液膜的缺失部分中，没有出现伦理问题，供应稳定，没有感染的风险，不会引起细胞变性，允许控制应用后的降解速率 并且具有促进生物膜再生的作用。

    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
    8.
    发明授权
    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same 失效
    通过磷酸盐，组合物，制品和制造和使用它们的方法延伸的可生物降解的聚合物

    公开(公告)号：US6166173A

    公开(公告)日：2000-12-26

    申请号：US53649

    申请日：1998-04-02

    申请人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： A61L27/00 ,  A61K9/00 ,  A61K9/16 ,  A61L17/10 ,  A61L17/12 ,  A61L24/00 ,  A61L26/00 ,  A61L27/14 ,  A61L27/18 ,  C08G63/692 ,  C08G63/91 ,  C08G69/42 ,  C08G79/04 ,  C08L67/00 ,  C08L77/00 ,  C08L85/02 ,  C08L101/16 ,  A61K31/80

    CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61L17/12 ,  A61L26/0019 ,  A61L27/18 ,  C08G63/6922 ,  C08G63/912 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M.sub.1 and M.sub.2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is --O--, --S-- or --NR'--, where R' is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat.Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

    摘要翻译： 描述包含式I或II所示的重复单体单元的生物可降解聚合物：其中X是-O-或-NR'-，其中R'是H或烷基; L是具有1-20个碳原子的支链或直链脂族基团; M1和M2各自独立地为（1）具有1-20个碳原子的支链或直链脂族基团; 或（2）具有1-20个碳原子的支链或直链，氧基，羧基或氨基 - 脂族基团; Y是-O - ， - S-或-NR'-，其中R'是H或烷基; R是H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; x：y的摩尔比为约1; 摩尔比n：（x或y）在约200:1和1:200之间; 并且摩尔比q：r在约1:99和99:1之间; 其中所述可生物降解聚合物在生物降解之前和之后是生物相容的。 还描述了制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及使用该聚合物可控地释放生物活性物质的方法。