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公开(公告)号:US20220241296A1
公开(公告)日:2022-08-04
申请号:US17629267
申请日:2020-07-21
发明人: Jean-Michel BUKOWSKI , Akshay NADKARNI , José L. BOYER , Brigitte DUQUESROIX-CHAKROUN , Tomas NAVRATIL
IPC分类号: A61K31/569 , A61K9/10 , A61K9/00 , A61K47/38 , A61K47/26 , A61K47/18 , A61K47/02 , A61K47/10 , A61P27/04
摘要: The present invention relates to an improved process of manufacturing sterile topical ophthalmic aqueous nanosuspensions of nanocrystals of fluticasone propionate Form A. The sterile topical ophthalmic nanosuspensions are useful in the treatment of eye inflammation conditions such as blepharitis, posterior blepharitis, Meibomian gland dysfunction and dry eye through topical administration of said nanosuspensions to eyelids, eyelashes and eyelid margin.
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公开(公告)号:US20210300963A1
公开(公告)日:2021-09-30
申请号:US17178026
申请日:2021-02-17
摘要: The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic gent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, Meibomian gland dysfuntion or skin inflammatiom or a respiratory disease (e.g., asthma).
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公开(公告)号:US20210177807A1
公开(公告)日:2021-06-17
申请号:US17113908
申请日:2020-12-07
IPC分类号: A61K31/4174 , A61K9/00 , A61K47/02 , A61K47/10 , A61K31/70 , A61K31/045 , A61K31/047
摘要: Methods of treating eyelid swelling in a subject comprising administering to the ocular surface of the subject an effective amount of glycerol and naphazoline. The glycerol can be present at a concentration of about 7.5% w/v and the naphazoline can be present at a concentration of about 0.01% to about 0.5% w/v. The compositions do not comprise an antihistamine.
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公开(公告)号:US09815865B2
公开(公告)日:2017-11-14
申请号:US14759133
申请日:2013-11-13
发明人: Shikha P. Barman , Ritesh Vasudevan Thekkedath , Koushik Barman , Thomas Cavanagh , Tian Hao , Thomas Bovard Leland
CPC分类号: C07J71/0031 , C07J3/005 , C07J5/0015 , C07J5/003 , C07J5/0038 , C07J5/0053 , C07J5/0076 , C07J5/0092 , C07J7/002 , C07J7/0045 , C07J7/0085 , C07J9/00 , C07J31/006 , C07J51/00 , Y10T428/2982
摘要: The present invention further provides method of preparing nanocrystals or microcrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).
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公开(公告)号:US20220323352A1
公开(公告)日:2022-10-13
申请号:US17850515
申请日:2022-06-27
发明人: Jean-Michel BUKOWSKI , Akshay NADKARNI , José L. BOYER , Brigitte DUQUESROIX-CHAKROUN , Tomas NAVRATIL
IPC分类号: A61K9/08 , A61P27/02 , A61K9/00 , A61K31/567 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/38
摘要: A process of manufacturing sterile topical ophthalmic aqueous nanosuspensions of nanocrystals of fluticasone propionate Form A. The sterile topical ophthalmic nanosuspensions may be used in the treatment of eye inflammation conditions such as blepharitis, posterior blepharitis, Meibomian gland dysfunction and dry eye through topical administration of said nanosuspensions to eyelids, eyelashes and eyelid margin.
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公开(公告)号:US09750684B2
公开(公告)日:2017-09-05
申请号:US14982258
申请日:2015-12-29
发明人: Mark Barry Abelson , Matthew J. Chapin , Paul Gomes , George Minno , Jackie Nice
IPC分类号: A61K31/495 , A61K31/569 , A61K31/4174 , A61K9/00 , A61K9/08 , A61K31/4965 , A61K31/56 , A61K47/10 , A61K47/18
CPC分类号: A61K31/495 , A61K9/0048 , A61K9/08 , A61K31/4174 , A61K31/4965 , A61K31/56 , A61K31/569 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/186 , A61K47/26 , A61K47/38
摘要: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
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公开(公告)号:US11406596B2
公开(公告)日:2022-08-09
申请号:US16934807
申请日:2020-07-21
发明人: Jean-Michel Bukowski , Akshay Nadkarni , José L. Boyer , Brigitte Duquesroix-Chakroun , Tomas Navratil
IPC分类号: A61K9/08 , A61P27/02 , A61K9/00 , A61K31/567 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/38 , B82Y5/00
摘要: A process of manufacturing sterile topical ophthalmic aqueous nanosuspensions of nanocrystals of fluticasone propionate Form A. The sterile topical ophthalmic nanosuspensions may be used in the treatment of eye inflammation conditions such as blepharitis, posterior blepharitis, Meibomian gland dysfunction and dry eye through topical administration of said nanosuspensions to eyelids, eyelashes and eyelid margin.
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公开(公告)号:US20210290617A1
公开(公告)日:2021-09-23
申请号:US17332814
申请日:2021-05-27
发明人: Mark Barry ABELSON , Matthew J. CHAPIN , Paul GOMES , George MINNO , Jackie NICE
IPC分类号: A61K31/495 , A61K9/08 , A61K31/4965 , A61K31/56 , A61K9/00 , A61K31/4174 , A61K31/569 , A61K47/10 , A61K47/02 , A61K47/26 , A61K47/38
摘要: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
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公开(公告)号:US10987352B2
公开(公告)日:2021-04-27
申请号:US16839954
申请日:2020-04-03
发明人: Mark Barry Abelson , Matthew J. Chapin , Paul Gomes , George Minno , Jackie Nice
IPC分类号: A61K31/495 , A61K31/569 , A61K31/4174 , A61K31/56 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/38 , A61K9/08 , A61K31/4965 , A61K9/00
摘要: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.
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公开(公告)号:US20210023001A1
公开(公告)日:2021-01-28
申请号:US16934807
申请日:2020-07-21
发明人: Jean-Michel BUKOWSKI , Akshay NADKARNI , José L. BOYER , Brigitte DUQUESROIX-CHAKROUN , Tomas NAVRATIL
IPC分类号: A61K9/08 , A61K31/567 , A61K47/38 , A61K47/02 , A61K47/18 , A61K47/26 , A61K47/10 , A61P27/02 , A61K9/00
摘要: A process of manufacturing sterile topical ophthalmic aqueous nanosuspensions of nanocrystals of fluticasone propionate Form A. The sterile topical ophthalmic nanosuspensions may be used in the treatment of eye inflammation conditions such as blepharitis, posterior blepharitis, Meibomian gland dysfunction and dry eye through topical administration of said nanosuspensions to eyelids, eyelashes and eyelid margin.
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