公开(公告)号：US20240226116A1

公开(公告)日：2024-07-11

申请号：US18608226

申请日：2024-03-18

申请人： CRITITECH, INC.

发明人： Michael BALTEZOR ,  Matthew MCCLOREY ,  Joseph S. FARTHING ,  Mark WILLIAMS ,  Jacob SITTENAUER

IPC分类号： A61K31/569 ,  A61K9/00 ,  A61K9/16 ,  A61K31/496 ,  A61P9/00

CPC分类号： A61K31/569 ,  A61K9/0075 ,  A61K9/1688 ,  A61K31/496 ,  A61P9/00

摘要： Disclosed herein are particles of at least 95% by weight of a glucocorticoid that have a specific surface area of at least 10 m2/g, methods for making, such particles, and methods for their use as therapeutics. Also disclosed herein are particles of at least 95% by weight of an indolinone that have a specific surface area of at least 10 m2/g, methods for making such particles, and methods for-their use as therapeutics.

公开(公告)号：US11957784B2

公开(公告)日：2024-04-16

申请号：US17740192

申请日：2022-05-09

申请人： Mati Therapeutics, Inc.

发明人： Deepank Utkhede ,  Catherine Jones ,  David J. Wiseman

IPC分类号： A61F9/00 ,  A61F9/007 ,  A61K9/00 ,  A61K9/14 ,  A61K31/165 ,  A61K31/569 ,  A61K31/573 ,  A61K38/13 ,  A61K47/10 ,  A61K47/34

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61F9/00772 ,  A61K9/146 ,  A61K31/165 ,  A61K31/569 ,  A61K31/573 ,  A61K38/13 ,  A61K47/10 ,  A61K47/34

摘要： A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.

公开(公告)号：US11931368B2

公开(公告)日：2024-03-19

申请号：US16650961

申请日：2018-09-28

申请人： CRITITECH, INC.

发明人： Michael Baltezor ,  Matthew McClorey ,  Joseph S. Farthing ,  Mark Williams ,  Jacob Sittenauer

IPC分类号： A61K31/569 ,  A61K9/00 ,  A61K9/16 ,  A61K31/496 ,  A61P9/00

CPC分类号： A61K31/569 ,  A61K9/0075 ,  A61K9/1688 ,  A61K31/496 ,  A61P9/00

摘要： Disclosed herein are particles of at least 95% by weight of a glucocorticoid that have a specific surface area of at least 10 m2/g, methods for making, such particles, and methods for their use as therapeutics. Also disclosed herein are particles of at least 95% by weight of an indolinone that have a specific surface area of at least 10 m2/g, methods for making such particles, and methods for-their use as therapeutics.

公开(公告)号：US11872318B2

公开(公告)日：2024-01-16

申请号：US18100363

申请日：2023-01-23

申请人： The Johns Hopkins University

发明人： Alexey Popov ,  Elizabeth M. Enlow ,  James Bourassa ,  Colin R. Gardner ,  Hongming Chen ,  Laura M. Ensign ,  Samuel K. Lai ,  Tao Yu ,  Justin Hanes ,  Ming Yang

IPC分类号： A61K9/50 ,  A61K47/34 ,  A61K9/10 ,  A61K9/51 ,  A61K31/12 ,  A61K31/341 ,  A61K31/405 ,  A61K31/409 ,  A61K31/496 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/675 ,  A61K49/00 ,  A61K31/569 ,  A61K31/635 ,  A61K31/662 ,  A61K31/522

CPC分类号： A61K9/5031 ,  A61K9/10 ,  A61K9/5089 ,  A61K9/5138 ,  A61K31/12 ,  A61K31/341 ,  A61K31/405 ,  A61K31/409 ,  A61K31/496 ,  A61K31/522 ,  A61K31/56 ,  A61K31/569 ,  A61K31/573 ,  A61K31/58 ,  A61K31/635 ,  A61K31/662 ,  A61K31/675 ,  A61K47/34 ,  A61K49/0089

摘要： Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

公开(公告)号：US11793953B2

公开(公告)日：2023-10-24

申请号：US17957079

申请日：2022-09-30

申请人： Norton (Waterford) Limited

发明人： Daniel Buck ,  Paul Prendergast ,  Declan Walsh

IPC分类号： A61M15/00 ,  A61P11/06 ,  A61P11/00 ,  A61K9/00 ,  A61K31/439 ,  A61K31/569 ,  A61K47/06 ,  A61M15/08 ,  B65D83/38 ,  B65D83/54

CPC分类号： A61M15/0066 ,  A61K9/007 ,  A61K31/439 ,  A61K31/569 ,  A61K47/06 ,  A61M15/009 ,  A61M15/0025 ,  A61M15/0071 ,  A61M15/0095 ,  A61M15/08 ,  A61P11/00 ,  A61P11/06 ,  A61M15/0026 ,  A61M15/0078 ,  A61M15/0091 ,  A61M2205/18 ,  A61M2205/276 ,  B65D83/386 ,  B65D83/54

摘要： A nasal inhaler for the inhalation of inhalable substances comprise: a canister having an interior reservoir containing pressurised inhalable substances including fluid; a metering valve including a metering chamber and a valve stem defining a communication path between the metering chamber and the interior reservoir, the communication path including an opening configured to permit flow between a transfer space inside the valve stem and the interior reservoir, the interior reservoir being arranged for orientation above the metering chamber whereby gas located within the metering chamber is replaced with liquid from the interior reservoir.

公开(公告)号：US11642317B2

公开(公告)日：2023-05-09

申请号：US16923980

申请日：2020-07-08

申请人： The Johns Hopkins University

发明人： Alexey Popov ,  Elizabeth M. Enlow ,  James Bourassa ,  Colin R. Gardner ,  Hongming Chen ,  Laura M. Ensign ,  Samuel K. Lai ,  Tao Yu ,  Justin Hanes ,  Ming Yang

IPC分类号： A61K9/50 ,  A61K47/34 ,  A61K9/10 ,  A61K9/51 ,  A61K31/12 ,  A61K31/341 ,  A61K31/405 ,  A61K31/409 ,  A61K31/496 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/675 ,  A61K49/00 ,  A61K31/569 ,  A61K31/635 ,  A61K31/662 ,  A61K31/522

CPC分类号： A61K9/5031 ,  A61K9/10 ,  A61K9/5089 ,  A61K9/5138 ,  A61K31/12 ,  A61K31/341 ,  A61K31/405 ,  A61K31/409 ,  A61K31/496 ,  A61K31/522 ,  A61K31/56 ,  A61K31/569 ,  A61K31/573 ,  A61K31/58 ,  A61K31/635 ,  A61K31/662 ,  A61K31/675 ,  A61K47/34 ,  A61K49/0089

摘要： Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

公开(公告)号：US20180264006A1

公开(公告)日：2018-09-20

申请号：US15761759

申请日：2016-09-22

申请人： REGENERA PHARMA LTD.

发明人： Zadik HAZAN ,  Konstantin ADAMSKY ,  Andre C. B. LUCASSEN ,  Nurit NOVAK

IPC分类号： A61K31/56 ,  A61K31/569 ,  A61K31/122 ,  A61K36/22

CPC分类号： A61K31/56 ,  A61K31/122 ,  A61K31/569 ,  A61K31/575 ,  A61K31/745 ,  A61K36/22 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to compositions and formulations comprising at least one triterpenoic acid and at least one neutral triterpenoid and uses thereof for treating for use in treating a condition selected from Alzheimer's disease (AD), Parkinson's Diseases (PD) and vascular dementia (VD).

公开(公告)号：US20180256603A1

公开(公告)日：2018-09-13

申请号：US15761755

申请日：2016-09-22

申请人： REGENERA PHARMA LTD.

发明人： Zadik HAZAN ,  Konstantin ADAMSKY ,  Andre C. B. LUCASSEN ,  Nurit NOVAK

IPC分类号： A61K31/575 ,  A61K31/56 ,  A61K31/047 ,  A61K31/122 ,  A61P9/10

CPC分类号： A61K31/575 ,  A61K31/047 ,  A61K31/122 ,  A61K31/56 ,  A61K31/569 ,  A61K31/745 ,  A61K36/22 ,  A61K45/06 ,  A61P9/10 ,  A61K2300/00

摘要： The invention relates to compositions and formulations comprising at least one triterpenoic acid and at least one neutral triterpenoid and uses thereof for treating stroke or trauma and side effects related thereto.

公开(公告)号：US20180104193A1

公开(公告)日：2018-04-19

申请号：US15705093

申请日：2017-09-14

申请人： Agile Therapeutics, Inc.

发明人： Thomas M. Rossi ,  Marie Foegh ,  Agis Kydonieus

IPC分类号： A61K9/70 ,  A61K31/569 ,  A61K45/06 ,  A61K31/57 ,  A61K31/567

CPC分类号： A61K9/703 ,  A61K9/7038 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/567 ,  A61K31/569 ,  A61K31/57 ,  A61K45/06 ,  A61K2300/00

摘要： Dosing regimens for transdermal delivery of hormones comprising a five week treatment cycle with a fixed treatment interval and a fixed rest interval.

公开(公告)号：US09925232B2

公开(公告)日：2018-03-27

申请号：US14338567

申请日：2014-07-23

申请人： Serenity Pharmaceuticals LLC

发明人： Seymour H. Fein ,  Linda Cheng ,  Maria Cheng ,  Samuel Herschkowitz

IPC分类号： A61K31/569 ,  A61K38/08 ,  A61K38/11 ,  A61K31/404 ,  A61K31/4375 ,  A61K31/473 ,  A61K31/58 ,  A61K45/06 ,  A61K31/56

CPC分类号： A61K38/11 ,  A61K31/404 ,  A61K31/4375 ,  A61K31/473 ,  A61K31/56 ,  A61K31/569 ,  A61K31/58 ,  A61K38/08 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides methods and compositions for use of desmopressin in combination with a 5-alpha reductase inhibitor. The methods and compositions are useful in the treatment of nocturia and other urinary frequency disorders.