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公开(公告)号:US20130273036A1
公开(公告)日:2013-10-17
申请号:US13851153
申请日:2013-03-27
IPC分类号: C07K16/22
CPC分类号: C07K16/2878 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
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公开(公告)号:US20150218278A1
公开(公告)日:2015-08-06
申请号:US14529890
申请日:2014-10-31
申请人: TransBio Ltd
IPC分类号: C07K16/28
CPC分类号: C07K16/2878 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
摘要翻译: 本公开提供了包含结合Fn14的抗体抗原结合结构域的蛋白质及其用途。 本公开还提供了治疗诸如恶病质之类的消耗性疾病的方法。
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公开(公告)号:US09006397B2
公开(公告)日:2015-04-14
申请号:US13851153
申请日:2013-03-27
CPC分类号: C07K16/2878 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
摘要翻译: 本公开提供了包含结合Fn14的抗体抗原结合结构域的蛋白质及其用途。 本公开还提供了治疗诸如恶病质之类的消耗性疾病的方法。
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公开(公告)号:US20130224116A1
公开(公告)日:2013-08-29
申请号:US13882806
申请日:2011-11-07
IPC分类号: A61K35/44 , G01N33/569 , C07K16/28 , C12N5/074 , G01N33/50 , C12N11/00 , C12Q1/37 , C12Q1/68
CPC分类号: C12Q1/6881 , A61K35/44 , A61K49/005 , C07K16/28 , C12N5/0692 , C12N11/00 , C12N2501/415 , C12Q1/37 , C12Q2600/158 , G01N33/5005 , G01N33/5064 , G01N33/56966 , G01N2333/70596 , G01N2800/60
摘要: The present invention provides markers of endothelial progenitor cells (EPCs) and use of those markers and reagents that bind thereto to detect EPC cells or diagnose, prognose, treat or prevent EPC-associated conditions.
摘要翻译: 本发明提供内皮祖细胞(EPCs)的标记物以及与其结合的那些标记物和试剂的检测以检测EPC细胞或诊断,预后,治疗或预防EPC相关病症。
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公开(公告)号:US20130171153A1
公开(公告)日:2013-07-04
申请号:US13640356
申请日:2011-04-18
申请人: Simon Barry , Doreen Krumbiegel , Nicola Ga-Ling Eastaff-Leung , Ian Cameron Nicholson , Heddy Zola
发明人: Simon Barry , Doreen Krumbiegel , Nicola Ga-Ling Eastaff-Leung , Ian Cameron Nicholson , Heddy Zola
IPC分类号: C07K16/38 , G01N33/569
CPC分类号: C07K16/38 , A61K2039/505 , C07K16/28 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N5/0637 , G01N33/56972
摘要: The present disclosure provides an isolated protein comprising at least one antibody variable region that is capable of binding to peptidase inhibitor 16 (PI16), wherein the protein is also capable of competitively inhibiting binding of an antibody produced by a hybridoma designated CRCBT-02-001 deposited with the ATCC under Accession Number PTA-10685 to PI16. The present invention also provides use of the protein, e.g., in diagnosis, therapy or to isolate cells, preferably Treg cells.
摘要翻译: 本公开提供了包含能够结合肽酶抑制剂16(PI16)的至少一个抗体可变区的分离蛋白,其中该蛋白还能够竞争性地抑制由称为CRCBT-02-001的杂交瘤产生的抗体的结合 以保藏号PTA-10685保藏到PI16。 本发明还提供蛋白质的用途,例如在诊断,治疗或分离细胞,优选Treg细胞中。
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