公开(公告)号：US20130171153A1

公开(公告)日：2013-07-04

申请号：US13640356

申请日：2011-04-18

申请人： Simon Barry ,  Doreen Krumbiegel ,  Nicola Ga-Ling Eastaff-Leung ,  Ian Cameron Nicholson ,  Heddy Zola

发明人： Simon Barry ,  Doreen Krumbiegel ,  Nicola Ga-Ling Eastaff-Leung ,  Ian Cameron Nicholson ,  Heddy Zola

IPC分类号： C07K16/38 ,  G01N33/569

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/0637 ,  G01N33/56972

摘要： The present disclosure provides an isolated protein comprising at least one antibody variable region that is capable of binding to peptidase inhibitor 16 (PI16), wherein the protein is also capable of competitively inhibiting binding of an antibody produced by a hybridoma designated CRCBT-02-001 deposited with the ATCC under Accession Number PTA-10685 to PI16. The present invention also provides use of the protein, e.g., in diagnosis, therapy or to isolate cells, preferably Treg cells.

摘要翻译： 本公开提供了包含能够结合肽酶抑制剂16（PI16）的至少一个抗体可变区的分离蛋白，其中该蛋白还能够竞争性地抑制由称为CRCBT-02-001的杂交瘤产生的抗体的结合 以保藏号PTA-10685保藏到PI16。 本发明还提供蛋白质的用途，例如在诊断，治疗或分离细胞，优选Treg细胞中。

公开(公告)号：US09605079B2

公开(公告)日：2017-03-28

申请号：US13640356

申请日：2011-04-18

申请人： Simon Barry ,  Doreen Krumbiegel ,  Nicola Ga-Ling Eastaff-Leung ,  Ian Cameron Nicholson ,  Heddy Zola

发明人： Simon Barry ,  Doreen Krumbiegel ,  Nicola Ga-Ling Eastaff-Leung ,  Ian Cameron Nicholson ,  Heddy Zola

IPC分类号： C07K16/38 ,  G01N33/569 ,  C07K16/28 ,  C12N5/0783 ,  A61K39/00

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/0637 ,  G01N33/56972

摘要： The present disclosure provides an isolated protein comprising at least one antibody variable region that is capable of binding to peptidase inhibitor 16 (PI16), wherein the protein is also capable of competitively inhibiting binding of an antibody produced by a hybridoma designated CRCBT-02-001 deposited with the ATCC under Accession Number PTA-10685 to PI16. The present invention also provides use of the protein, e.g., in diagnosis, therapy or to isolate cells, preferably Treg cells.

公开(公告)号：US20120064100A1

公开(公告)日：2012-03-15

申请号：US13256992

申请日：2010-03-18

申请人： Simon Barry ,  Timothy John Sadlon ,  Stephen Martin Pederson ,  Bridget Gabrielle Wilkinson ,  Doreen Krumbiegel ,  Ian Cameron Nicholson ,  Heddy Zola

发明人： Simon Barry ,  Timothy John Sadlon ,  Stephen Martin Pederson ,  Bridget Gabrielle Wilkinson ,  Doreen Krumbiegel ,  Ian Cameron Nicholson ,  Heddy Zola

IPC分类号： A61K35/14 ,  C12N5/0783 ,  A61P37/02 ,  C40B30/04 ,  C12Q1/68 ,  G01N33/577 ,  G01N33/569 ,  A61P37/06

CPC分类号： G01N33/56972 ,  A61K35/17 ,  A61K2035/122 ,  A61K2039/505 ,  C07K16/38 ,  C12N5/0637 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/102 ,  G01N2800/24 ,  G01N2800/245

摘要： The present invention provides markers of regulatory T (Treg) cells, preferably, cell surface markers of Treg cells and uses of those markers or compounds that bind thereto to identify or isolate Treg cells or to diagnose/prognose/treat/prevent Treg-mediated conditions. The present invention also provides methods for identification and/or isolation of Treg cell subpopulations and such isolated subpopulations of Treg cells.

摘要翻译： 本发明提供调节T（Treg）细胞的标志物，优选Treg细胞的细胞表面标志物以及与其结合的那些标记物或化合物用于鉴定或分离Treg细胞或诊断/预后/预防Treg介导的病症 。 本发明还提供用于鉴定和/或分离Treg细胞亚群和这种分离的Treg细胞亚群的方法。