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    Fluoroquinoline derivative
    1.
    发明授权
    Fluoroquinoline derivative 失效
    氟喹啉衍生物

    公开(公告)号：US5776948A

    公开(公告)日：1998-07-07

    申请号：US728431

    申请日：1996-10-09

    申请人： Takeshi Yokota ,  Masayuki Haramura ,  Akira Okamachi ,  Toshihiko Makino

    发明人： Takeshi Yokota ,  Masayuki Haramura ,  Akira Okamachi ,  Toshihiko Makino

    IPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/04 ,  A61K31/47 ,  C07D215/18 ,  C07D215/233

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/04

    摘要： Antibacterial fluoroquinoline derivatives and salts thereof of the following formula are stable and have low toxicity and high photostability and low cytotoxicity under light irradiation: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen, optionally protected amino, optionally protected aminocarbonyl or optionally protected carboxyl; R.sub.5 is halogen, lower alkyl or optionally protected hydroxyl or is the same as R.sub.2 ; R.sub.6 is lower alkyl; A is CH.sub.2, optionally protected nitrogen or oxygen; and n and m are each an integer of from 0 to 4, provided that n +m is an integer of from 1 to 4.

    摘要翻译： 下式的抗菌氟喹啉衍生物及其盐是稳定的，并且在光照射下具有低毒性和高光稳定性和低细胞毒性：其中R1是氢或低级烷基; R2是氢，任选保护的氨基，任选保护的氨基羰基或任选被保护的羧基; R5是卤素，低级烷基或任意保护的羟基或与R2相同; R6是低级烷基; A是CH 2，任选地保护的氮或氧; n和m各自为0〜4的整数，条件是n + m为1〜4的整数。