公开(公告)号：US20240199822A1

公开(公告)日：2024-06-20

申请号：US18590007

申请日：2024-02-28

申请人： Galderma Holding SA

发明人： Johan OLSSON ,  Craig Steven HARRIS

IPC分类号： C08J3/075 ,  A61K8/04 ,  A61K8/73 ,  A61K9/00 ,  A61Q19/00 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/08 ,  C08B37/00 ,  C08B37/08 ,  C08J3/24 ,  C08J7/14 ,  C08K5/09 ,  C08L5/00 ,  C08L5/08

CPC分类号： C08J3/075 ,  A61K8/042 ,  A61K8/73 ,  A61K8/735 ,  A61K9/0019 ,  A61Q19/00 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/083 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08J3/24 ,  C08J7/14 ,  C08K5/09 ,  C08L5/00 ,  C08L5/08 ,  C07C2603/18 ,  C08J2305/00 ,  C08J2305/08

摘要： A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.

公开(公告)号：US20240182651A1

公开(公告)日：2024-06-06

申请号：US18168938

申请日：2023-02-14

申请人： Win Coat Corporation

发明人： Ta-Jo LIU ,  Hsiu-Feng YEH ,  Shin-Yi YIN ,  Yi-Jyun LIAO ,  Ying-Hua HSU

IPC分类号： C08J3/075 ,  C08B37/08 ,  C08J3/28

CPC分类号： C08J3/075 ,  C08B37/0072 ,  C08J3/28 ,  C08J2305/08 ,  C08J2367/07

摘要： Provided is a hydrogel composition, which comprises a modified HA, PEGDA and water; wherein, based on a total weight of the hydrogel composition, a content of the modified HA is 1 wt % to 7 wt % and a content of PEGDA is 43 wt % to 49 wt %; the modified HA is obtained by modifying HA with methacrylic anhydride; an average molecular weight of PEGDA is 1 kDa to 10 kDa. The hydrogel composition of the present invention has good compatibility of raw materials, which does not cause HA precipitation, and a hydrogel material produced therefrom simultaneously has good mechanical properties, good swell capability and good biocompatibility, such that the hydrogel material can be applied in many fields.

公开(公告)号：US20240132630A1

公开(公告)日：2024-04-25

申请号：US18480242

申请日：2023-10-03

申请人： Navidea Biopharmaceuticals, Inc.

发明人： Jeffrey Scott Arnold ,  David A. Ralph

IPC分类号： C08B37/02 ,  A61K31/717 ,  A61K31/721 ,  A61K31/722 ,  A61K31/728 ,  C08B37/00 ,  C08B37/08

CPC分类号： C08B37/0021 ,  A61K31/717 ,  A61K31/721 ,  A61K31/722 ,  A61K31/728 ,  C08B37/003 ,  C08B37/0072 ,  C08B37/0087

摘要： Provided are methods of attaching a mannose-binding C-type lectin receptor targeting moiety to a polymeric carbohydrate backbone using an amide linkage. The amide linkage may be found between a leash, such as an amine terminated leash, and the mannose-binding C-type lectin receptor targeting moieties. The compounds and compositions disclosed utilizing the amide linkage provide for highly stable compounds with a significant reduction in loss of mannose-binding C-type lectin receptor targeting moieties from the polymeric carbohydrate backbone.

公开(公告)号：US20240124656A1

公开(公告)日：2024-04-18

申请号：US18474363

申请日：2023-09-26

申请人： POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

发明人： Hyung Joon Cha ,  Jae Yun Lee ,  Jin Young Yun ,  Hyun Tack Woo

IPC分类号： C08H1/00 ,  C07K14/435 ,  C08B37/08

CPC分类号： C08H1/00 ,  C07K14/43504 ,  C08B37/0072

摘要： The present disclosure relates to a conductive hydrogel including a mussel adhesive protein, a liquid metal, and hyaluronic acid and a preparation method thereof.

公开(公告)号：US11939433B2

公开(公告)日：2024-03-26

申请号：US18208527

申请日：2023-06-12

申请人： Galderma Holding SA

发明人： Johan Olsson ,  Craig Steven Harris

IPC分类号： C08J3/075 ,  A61K8/04 ,  A61K8/73 ,  A61K9/00 ,  A61Q19/00 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/08 ,  C08B37/00 ,  C08B37/08 ,  C08J3/24 ,  C08J7/14 ,  C08K5/09 ,  C08L5/00 ,  C08L5/08

CPC分类号： C08J3/075 ,  A61K8/042 ,  A61K8/73 ,  A61K8/735 ,  A61K9/0019 ,  A61Q19/00 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/083 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08J3/24 ,  C08J7/14 ,  C08K5/09 ,  C08L5/00 ,  C08L5/08 ,  C07C2603/18 ,  C08J2305/00 ,  C08J2305/08

摘要： A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.

公开(公告)号：US11939409B2

公开(公告)日：2024-03-26

申请号：US17256182

申请日：2019-06-11

申请人： HALLURA LTD.

发明人： Stephane Meunier ,  Svetlana Shneider ,  Elena Ragozin

IPC分类号： C08B37/08 ,  A61L27/20 ,  A61L27/52 ,  C07D237/26 ,  C07D257/08

CPC分类号： C08B37/0072 ,  A61L27/20 ,  A61L27/52 ,  C07D237/26 ,  C07D257/08 ,  A61L2300/402 ,  A61L2300/428 ,  A61L2400/06

摘要： The present invention is directed to a polymer comprising a first hyaluronic acid (HA) chain and a second HA chain crosslinked via a linker comprising an unsaturated moiety or a derivative thereof coupled to a tetrazine moiety or a derivative thereof. In some embodiments, the polymer of the invention is characterized by having a crosslinking degree of 0.2 to 4%.

公开(公告)号：US11920026B2

公开(公告)日：2024-03-05

申请号：US16845636

申请日：2020-04-10

申请人： i-CoreBio Inc.

发明人： Jae Ho Shin ,  Ki Hak Gwon

IPC分类号： C08L5/08 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  D01D1/02 ,  D01D5/00 ,  D01D5/38 ,  B82Y30/00 ,  C08B37/08

CPC分类号： C08L5/08 ,  A61L31/042 ,  A61L31/148 ,  A61L31/16 ,  D01D1/02 ,  D01D5/0015 ,  D01D5/38 ,  A61L2300/114 ,  A61L2400/12 ,  B82Y30/00 ,  C08B37/0072 ,  C08L2201/06 ,  C08L2203/12

摘要： Disclosed herein is a novel polymer having a structure based on a biodegradable polymer. In the novel polymer, the biodegradable polymer has at least one kind of functional groups from among a hydroxyl group and a carboxyl group, wherein the biodegradable polymer bears a functional group conjugated with a nitric oxide-releasing compound and a different functional group substituted with a photopolymerizable functional group, the nitric oxide-releasing compound comprising a NO donor. Also provided is a nanofiber fabricated from the modified biodegradable polymer. The nanofiber can be fabricated by electrospinning the novel polymer.

公开(公告)号：US20240050628A1

公开(公告)日：2024-02-15

申请号：US18269760

申请日：2021-12-28

申请人： VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI

发明人： Faruk OYTUN ,  Mustafa CIFTCI ,  Busra Gizem KAYA

IPC分类号： A61L27/52 ,  C08B37/08 ,  C08J3/075 ,  C08L5/08 ,  A61L27/20

CPC分类号： A61L27/52 ,  C08B37/0072 ,  C08J3/075 ,  C08L5/08 ,  A61L27/20 ,  C08J2305/08 ,  A61L2430/06 ,  A61L2400/06

摘要： An injectable viscoelastic hydrogel formulation comprising photocrosslinked hyaluronic acid in order to relieve pain caused by osteoarthritis (OA), to support synovial fluid which has decreased activity, and to treat osteochondral lesions is provided. In the production of hyaluronic acid (HA) hydrogels, the crosslinking process is carried out via biocompatible camphorquinone instead of synthetic crosslinkers having toxic effects. Therefore, long process times in the purification process of synthetic crosslinkers are significantly reduced with the present invention.

公开(公告)号：US20230416469A1

公开(公告)日：2023-12-28

申请号：US18242468

申请日：2023-09-05

申请人： Galderma Holding SA

发明人： Hotan MOJARRADI ,  Johan OLSSON ,  Craig Steven HARRIS ,  Jean-Guy BOITEAU ,  Thibaut GERFAUD ,  Loïc TOMAS

IPC分类号： C08J3/075 ,  C08B37/00 ,  C08B37/08 ,  C08L5/00 ,  C08J3/24 ,  C08L5/08 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/08 ,  C08J7/14 ,  C08K5/09 ,  A61K8/04 ,  A61K8/73 ,  A61Q19/00 ,  A61K9/00

CPC分类号： C08J3/075 ,  C08B37/0069 ,  C08B37/0072 ,  C08L5/00 ,  C08J3/24 ,  C08L5/08 ,  C08B37/0063 ,  C07C209/62 ,  C07C213/00 ,  C07C269/06 ,  C07F7/083 ,  C08J7/14 ,  C08K5/09 ,  A61K8/042 ,  A61K8/73 ,  A61K8/735 ,  A61Q19/00 ,  A61K9/0019 ,  C08J2305/00 ,  C08J2305/08 ,  C07C2603/18

摘要： The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.

公开(公告)号：US11845813B2

公开(公告)日：2023-12-19

申请号：US17845038

申请日：2022-06-21

申请人： Bausch & Lomb Incorporated

发明人： George L Grobe, III ,  Alok Kumar Awasthi ,  Mark R. Mis ,  Jennah L. Wolcott ,  James R. Hauenstein

IPC分类号： C08B37/00 ,  A45C11/00 ,  A61K9/00 ,  A61K31/726 ,  A61K31/728 ,  A61L26/00 ,  A61L27/34 ,  C08B37/08 ,  G02C7/04

CPC分类号： C08B37/0069 ,  A45C11/005 ,  A61K9/0048 ,  A61K31/726 ,  A61K31/728 ,  A61L26/0023 ,  A61L27/34 ,  C08B37/0072 ,  G02C7/049

摘要： A packaging system for the storage of an ophthalmic device includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more crosslinked polymeric networks. The one or more crosslinked polymeric network comprises a reaction product of a first glycosaminoglycan, a second glycosaminoglycan, and a first crosslinking agent, wherein the first glycosaminoglycan is different than the second glycosaminoglycan. The aqueous packaging solution has an osmolality of at least about 180 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.