公开(公告)号：US20100016275A1

公开(公告)日：2010-01-21

申请号：US12503433

申请日：2009-07-15

Applicant: PREMJI MEGHANI ,  ANDREW JAMES ROBBINS ,  JEFFREY PAUL STONEHOUSE

Inventor： PREMJI MEGHANI ,  ANDREW JAMES ROBBINS ,  JEFFREY PAUL STONEHOUSE

IPC: A61K31/506 ,  C07D403/12 ,  C07D239/24 ,  A61K31/505

CPC classification number: C07D239/48 ,  C07D239/69

Abstract: A compound of formula (1) and pharmaceutically acceptable salts thereof for use in the treatment of chemokine mediated diseases and conditions.

Abstract translation: 式（1）化合物及其药学上可接受的盐，用于治疗趋化因子介导的疾病和病症。

公开(公告)号：US20120322788A1

公开(公告)日：2012-12-20

申请号：US13437410

申请日：2012-04-02

Applicant: Lilian Alcaraz ,  Andrew Bailey ,  Richard James Bull ,  Timothy Johnson ,  Nicholas David Kindon ,  Andrew Stuart Lister ,  Andrew James Robbins ,  Michael John Stocks ,  Barry John Teobald

Inventor： Lilian Alcaraz ,  Andrew Bailey ,  Richard James Bull ,  Timothy Johnson ,  Nicholas David Kindon ,  Andrew Stuart Lister ,  Andrew James Robbins ,  Michael John Stocks ,  Barry John Teobald

IPC: C07D498/10 ,  A61K31/553 ,  A61P29/00 ,  A61K31/5386

CPC classification number: C07D498/10

Abstract: The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.

Abstract translation: 本发明涉及式I的螺环酰胺衍生物，其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US20090298807A1

公开(公告)日：2009-12-03

申请号：US12365570

申请日：2009-02-04

Applicant: Lilian Alcaraz ,  Andrew Bailey ,  Richard James Bull ,  Timothy Johnson ,  Nicholas David Kindon ,  Andrew Stuart Lister ,  Andrew James Robbins ,  Michael John Stocks ,  Barry John Teobald

Inventor： Lilian Alcaraz ,  Andrew Bailey ,  Richard James Bull ,  Timothy Johnson ,  Nicholas David Kindon ,  Andrew Stuart Lister ,  Andrew James Robbins ,  Michael John Stocks ,  Barry John Teobald

IPC: A61K31/5386 ,  C07D498/10 ,  A61K31/553 ,  A61P29/00

CPC classification number: C07D498/10

Abstract: The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.

Abstract translation: 本发明涉及式I的螺环酰胺衍生物，其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途。