公开(公告)号：US20190090749A1

公开(公告)日：2019-03-28

申请号：US16141605

申请日：2018-09-25

Applicant: Eric Leuthardt ,  Carl Hacker ,  Shan Siddiqi ,  Tim Laumann ,  Andy Daniel

Inventor： Eric Leuthardt ,  Carl Hacker ,  Shan Siddiqi ,  Tim Laumann ,  Andy Daniel

IPC: A61B5/00 ,  A61B34/10 ,  A61B5/055 ,  G06K9/62

Abstract: A method for determining a target location for a therapeutic intervention in a subject with a neurological disorder is disclosed that includes selecting the target location within at least one resting state network (RSN) map according to a predetermined criterion for the neurological disorder. Each of the at least one RSN maps includes a plurality of functional voxels within a brain of the subject, and each functional voxel of the plurality of functional voxels is associated with a probability of membership in an RSN. A method for monitoring an efficacy of a therapeutic intervention in a subject with a neurological disorder is also disclosed that includes comparing at least a portion of at least one pre-treatment RSN map of the subject prior to the therapeutic intervention, at least one post-treatment RSN map of the subject after the therapeutic intervention to determine changes in the at least one post-treatment RSN map. The method for monitoring the efficacy of the therapeutic intervention efficacy also includes determining the efficacy of the therapeutic intervention based on the identified changes according to an efficacy criterion. In addition, a method for selecting a seed region for use in a seed-based cortical functional mapping method is disclosed that includes selecting a contiguous subset of the functional voxels probability of membership in the RSN above a threshold value from at least one RSN map of at least one subject as the seed region.

公开(公告)号：US11704790B2

公开(公告)日：2023-07-18

申请号：US16141605

申请日：2018-09-25

Applicant: Eric Leuthardt ,  Carl Hacker ,  Shan Siddiqi ,  Tim Laumann ,  Andy Daniel

Inventor： Eric Leuthardt ,  Carl Hacker ,  Shan Siddiqi ,  Tim Laumann ,  Andy Daniel

IPC: A61B5/00 ,  G06T7/00 ,  A61B34/10 ,  A61B5/055 ,  G16H30/40 ,  G06N3/00 ,  G16H50/20 ,  G06F18/213 ,  G06F18/21 ,  G06F18/2415 ,  G06F18/2413 ,  G06V10/764 ,  G01R33/48 ,  G16H20/40

CPC classification number: G06T7/0012 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4064 ,  A61B34/10 ,  G06F18/213 ,  G06F18/2178 ,  G06F18/2415 ,  G06F18/24133 ,  G06N3/00 ,  G06V10/764 ,  G16H30/40 ,  G16H50/20 ,  A61B5/4848 ,  A61B5/7267 ,  A61B2034/107 ,  A61B2576/026 ,  G01R33/4806 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30016 ,  G06V2201/031 ,  G16H20/40

Abstract: A target location for a therapeutic intervention is determined in a subject with a neurological disorder. The target location is selected within at least one resting state network (RSN) map according to a predetermined criterion for the neurological disorder. The at least one RSN map includes a plurality of functional voxels within a brain of the subject, and each functional voxel of the plurality of functional voxels is associated with a probability of membership in an RSN. Instructions are transmitted to a treatment system that cause operation to be performed on the selected target location.