Process and intermediates for the production of 7-substituted antiestrogens
    1.
    发明申请
    Process and intermediates for the production of 7-substituted antiestrogens 有权
    用于生产7-取代的抗雌激素的方法和中间体

    公开(公告)号:US20050101583A1

    公开(公告)日:2005-05-12

    申请号:US10398924

    申请日:2001-10-09

    摘要: A process for preparing an intermediate compound of formula (II) where X is as defined in the specification, R1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R2, R3, R4 and R5 are organic groups as defined in the specification, which process comprises aromatisation of a compound of formula (III) where R1, R2, R3, n, X and R5 are as defined in relation to formula (II) and R4′ is a group R4 or a precursor group thereof, and thereafter if necessary or desired, carrying out one or more of the following steps: (i) removing any hydroxy-protecting groups R; (ii) converting a precursor group R4′ to a group R4, or where R4′ is a group R4, converting it to a different such group. Compounds obtained are useful intermediates for example in the preparation of fulvestrant. Novel intermediates are also claimed.

    摘要翻译: 制备其中X如说明书中所定义的式(II)的中间体化合物的方法是卤代烷基,烷基,烯基,环烷基,羧基烷基,烷氧基羰基烷基,芳基或芳基烷基; R 2,R 3,R 4和R 5是说明书中定义的有机基团,该方法 包括式(III)化合物的芳构化,其中R 1,R 2,R 3,R 3,n,X和R 5 如式(II)所定义,并且R 4'是基团R 4或其前体基团,然后如果需要或需要, 进行一个或多个以下步骤:(i)除去任何羟基保护基团R; (ii)将前体基团R 4'转化成基团R 4,或其中R 4'是基团R 4 ,将其转换为不同的这样的组。 获得的化合物是例如制备氟维司群的有用的中间体。 还要求新的中间体。

    Fanless computer case
    2.
    发明授权

    公开(公告)号:US12075600B1

    公开(公告)日:2024-08-27

    申请号:US17861139

    申请日:2022-07-08

    IPC分类号: H05K7/20 G06F1/20

    摘要: A fanless computer case assembly is configured to distribute heat from a computer through a thermal accessory. The fanless computer case assembly includes a fanless computer case that has a bottom cover joined to a front panel and a rear panel. A top cover is joined to the front panel and the rear panel. A mother board includes a central processing unit is arranged between the front panel and the rear panel. An upper CPU mounting plate and a lower CPU mounting plate are joined to the central processing unit. A base plate is attached to the upper CPU mounting plate and the top cover with a spacer creating an air gap between the base plate and the top cover. A first heat transfer plate is attached to the lower CPU mounting plate and the bottom cover.

    MULTI-PARTNER CUSTOMS BROKING
    3.
    发明申请
    MULTI-PARTNER CUSTOMS BROKING 审中-公开
    多合作伙伴海关交易

    公开(公告)号:US20090282049A1

    公开(公告)日:2009-11-12

    申请号:US12119149

    申请日:2008-05-12

    IPC分类号: G06F17/30 G06Q30/00 G06F15/16

    CPC分类号: G06Q10/10

    摘要: Systems and methods for customs broking are discussed. The computer implemented method comprises receiving a first data group from a first user, determining a second data group based on the first data group, the second data group configured to identify data elements, receiving at least some of the data elements from the first user, receiving a third data group from a second user, and based on the reception of data elements received from the first user, receiving data elements from the second user. The first data group comprises information for defining a transaction of one or more goods. The data elements are used for a customs classification of the one or more goods. The third data group comprising information for further defining the transaction of the one or more goods.

    摘要翻译: 讨论了海关经纪的制度和方法。 计算机实现的方法包括从第一用户接收第一数据组,基于第一数据组确定第二数据组,第二数据组被配置为识别数据元素,从第一用户接收至少一些数据元素, 从第二用户接收第三数据组,并且基于从第一用户接收的数据元素的接收,从第二用户接收数据元素。 第一数据组包括用于定义一个或多个商品的交易的信息。 数据元素用于一种或多种商品的海关分类。 第三数据组包括用于进一步定义一个或多个商品的交易的信息。