公开(公告)号：US20110034473A1

公开(公告)日：2011-02-10

申请号：US12937245

申请日：2009-04-08

申请人： Victor J. Bauer ,  Mike H. O'Neill ,  Barbara J. Kidon ,  Burkhard Jansen

发明人： Victor J. Bauer ,  Mike H. O'Neill ,  Barbara J. Kidon ,  Burkhard Jansen

IPC分类号： A61K31/4985 ,  A61P35/00 ,  A61P35/02 ,  C07D487/04

CPC分类号： C07D487/04

摘要： A novel co-crystal of N′-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when administered as a suspension.

摘要翻译： 公开了N' - （7-氟吡咯并[1,2a]喹喔啉-4-基）吡嗪-2-碳酰肼与草酸的新型共晶体。 所公开的草酸共晶体表现为癌细胞生长抑制，并且当作为悬浮液施用时比相应的游离碱更具生物利用度。

公开(公告)号：US08058437B2

公开(公告)日：2011-11-15

申请号：US12937245

申请日：2009-04-08

申请人： Victor J Bauer ,  Mike H O'Neill ,  Barbara J Kidon ,  Burkhard Jansen

发明人： Victor J Bauer ,  Mike H O'Neill ,  Barbara J Kidon ,  Burkhard Jansen

IPC分类号： C07D241/42 ,  A61K31/498

CPC分类号： C07D487/04

摘要： A novel co-crystal of N′-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when administered as a suspension.

摘要翻译： 公开了N' - （7-氟吡咯并[1,2a]喹喔啉-4-基）吡嗪-2-碳酰肼与草酸的新型共晶体。 所公开的草酸共晶体表现为癌细胞生长抑制，并且当作为悬浮液施用时比相应的游离碱更具生物利用度。

公开(公告)号：US06361673B1

公开(公告)日：2002-03-26

申请号：US09604630

申请日：2000-06-27

申请人： Thomas J. Ameen ,  Barbara J. Kidon ,  Peter Peckham

发明人： Thomas J. Ameen ,  Barbara J. Kidon ,  Peter Peckham

IPC分类号： C25D104

CPC分类号： C25D5/10 ,  C25D1/04 ,  H05K3/384

摘要： An apparatus for producing metal foil, comprising a drum cathode having an outer plating surface. The drum cathode is partially immersed to a set level in an electrolyte bath and is rotatable in a fixed direction about a generally horizontal axis. A main anode assembly having a main anode is immersed in the electrolyte bath, the main anode having a semi-cylindrical curved anode surface facing the drum cathode. The main anode is dimensioned to be spaced from the plating surface of the drum cathode so as to define a generally uniform gap therebetween. An energy source is connected to the main anode for energizing the main anode. A chamber containing an electrolyte solution is disposed above the electrolyte bath and adjacent the cathode drum where the cathode drum exits the electrolyte bath. A treatment anode is immersed in the electrolyte solution in the chamber adjacent the drum cathode. An energy source is connected to the treatment anode for energizing the treatment anode.

摘要翻译： 一种用于生产金属箔的设备，包括具有外镀层表面的鼓形阴极。 鼓式阴极在电解质浴中部分地浸入设定的水平，并且可以围绕大致水平轴线沿固定方向旋转。 具有主阳极的主阳极组件浸入电解槽中，主阳极具有面向鼓阴极的半圆柱形弯曲阳极表面。 主阳极的尺寸设置成与鼓形阴极的电镀表面间隔开，以便在它们之间限定大致均匀的间隙。 能量源连接到主阳极，用于激励主阳极。 包含电解质溶液的室设置在电解质浴池的上方并且与阴极鼓相邻并且阴极鼓离开电解质浴池。 将处理阳极浸入与鼓阴极相邻的室中的电解液中。 能量源连接到处理阳极以激励处理阳极。