公开(公告)号：US20240391930A1

公开(公告)日：2024-11-28

申请号：US18670537

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： Marie-Gabrielle BRAUN ,  Georgette CASTANEDO ,  William VERNIER ,  Matthew VOLGRAF ,  Michael SIU ,  James Guy BREITENBUCHER

IPC: C07D495/10 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.

公开(公告)号：US20240400579A1

公开(公告)日：2024-12-05

申请号：US18670520

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： William VERNIER ,  Matthew VOLGRAF ,  Marie-Gabrielle BRAUN ,  Georgette Marie CASTANEDO ,  Paul Anthony GIBBONS ,  James Guy BREITENBUCHER ,  Drew ADAMS ,  Brad LANG

IPC: C07D495/10 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/506

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of myelin-related disorders.

公开(公告)号：US20240398781A1

公开(公告)日：2024-12-05

申请号：US18670608

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： Marie-Gabrielle BRAUN ,  Georgette CASTANEDO ,  William VERNIER ,  Matthew VOLGRAF ,  James Guy BREITENBUCHER ,  Brad LANG

IPC: A61K31/4545 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  C07D495/10

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.

公开(公告)号：US20220024851A1

公开(公告)日：2022-01-27

申请号：US17299463

申请日：2019-12-02

Applicant: Convelo Therapeutics, Inc.

Inventor： Bradley T. Lang ,  Emily M. Rigsbee ,  Ekaterina V. Albert

IPC: C07C211/40 ,  C07C309/04 ,  C07C65/10 ,  A61K45/06 ,  A61K31/136 ,  A61K31/192 ,  A61P25/28

Abstract: The invention is directed at esylate and salicylate salts of cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)prop-2-enylamine and their pharmaceutical composition. The invention is also directed at the use esylate and salicylate salts of cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-yclohexylphenyl)prop-2-enylamine and their pharmaceutical composition in treatment of myelin-related disorders.