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1.发明申请System for manufacturing controlled release dosage forms, such as zero-order release profile dosage form manufactured by three-dimensional printing 有权用于制造控制释放剂型的制剂，例如通过三维印刷制造的零级释放型剂量形式公开(公告)号：US20080220061A1
公开(公告)日：2008-09-11
申请号：US11876153
申请日：2007-10-22
IPC分类号： A61K9/24
CPC分类号： A61K9/2893 , A61J3/10 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/2095 , B33Y70/00 , B33Y80/00
摘要： The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.
摘要翻译： 本发明包括控制释放剂型和设计和制造剂型以获得特定释放特征的方法，例如零级释放曲线，升级释放曲线或减少释放曲线。 本发明的剂型可以包括剂型中API浓度的空间变化，并且可以包括嵌套区域。 根据本发明的剂型可以通过用于获得本文公开的用于产生零级释放曲线和增加或减少释放曲线的内部结构的任何适当方法来制造。 本发明还包括制造这种剂型的方法，例如通过三维印刷，可能还包括在三维印刷后压制剂型。 本发明还包括设计这种剂型的方法。 可以基于使用均匀浓度剂型的简单实验来预测API浓度不均匀分布的释放曲线。
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2.发明授权System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form 有权用于单轴压缩制品的系统和方法，例如三维印刷的剂型公开(公告)号：US08758658B2
公开(公告)日：2014-06-24
申请号：US12979484
申请日：2010-12-28
CPC分类号： A61K9/20 , A61J3/10 , A61K9/2095 , B29C64/00 , B29C64/165 , B29C67/0051 , B29C67/0081 , B29L2031/753 , B33Y70/00 , B33Y80/00
摘要： A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.
摘要翻译： 通过三维印刷制造的单轴压缩剂型，其保持了剂型的预定内部结构，同时产生改进的表面光洁度。 压缩压缩剂型，消除了在传统三维印刷结束时保留的至少一些空隙空间。 作为单轴压缩方法的结果获得的表面光洁度可以基本上等于从常规压片获得的表面光洁度。 此外，在压制操作期间保留了剂型的组成的内部结构或空间变化，几何收缩主要发生在按压轴的方向上。 此外，作为压缩的结果，可以将更大量的API包装在给定的最终体积的剂型中。
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3.发明申请System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form 有权用于单轴压缩制品的系统和方法，例如三维印刷的剂型公开(公告)号：US20110187015A1
公开(公告)日：2011-08-04
申请号：US12979484
申请日：2010-12-28
IPC分类号： A61K9/20
CPC分类号： A61K9/20 , A61J3/10 , A61K9/2095 , B29C64/00 , B29C64/165 , B29C67/0051 , B29C67/0081 , B29L2031/753 , B33Y70/00 , B33Y80/00
摘要： A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.
摘要翻译： 通过三维印刷制造的单轴压缩剂型，其保持了剂型的预定内部结构，同时产生改进的表面光洁度。 压缩压缩剂型，消除了在传统三维印刷结束时保留的至少一些空隙空间。 作为单轴压缩方法的结果获得的表面光洁度可以基本上等于从常规压片获得的表面光洁度。 此外，在压制操作期间保留了剂型的组成的内部结构或空间变化，几何收缩主要发生在按压轴的方向上。 此外，作为压缩的结果，可以将更大量的API包装在给定的最终体积的剂型中。
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4.发明授权System for manufacturing controlled release dosage forms, such as zero-order release profile dosage form manufactured by three-dimensional printing 有权用于制造控制释放剂型的制剂，例如通过三维印刷制造的零级释放型剂量形式公开(公告)号：US07820201B2
公开(公告)日：2010-10-26
申请号：US11876153
申请日：2007-10-22
CPC分类号： A61K9/2893 , A61J3/10 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/2095 , B33Y70/00 , B33Y80/00
摘要： The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.
摘要翻译： 本发明包括控制释放剂型和设计和制造剂型以获得特定释放特征的方法，例如零级释放曲线，升级释放曲线或减少释放曲线。 本发明的剂型可以包括剂型中API浓度的空间变化，并且可以包括嵌套区域。 根据本发明的剂型可以通过用于获得本文公开的用于产生零级释放曲线和增加或减少释放曲线的内部结构的任何适当方法来制造。 本发明还包括制造这种剂型的方法，例如通过三维印刷，可能还包括在三维印刷后压制剂型。 本发明还包括设计这种剂型的方法。 可以基于使用均匀浓度剂型的简单实验来预测API浓度不均匀分布的释放曲线。
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公开(公告)号：US06547994B1
公开(公告)日：2003-04-15
申请号：US09439179
申请日：1999-11-12
IPC分类号： B29C4102
CPC分类号： B29C64/165 , B29L2031/753 , B33Y80/00
摘要： A fabrication method to rapidly fabricate different prototypes of drug delivery systems, medical devices, pharmaceutical dosage forms, tissue scaffolds or other bioaffecting agents in small batches or individual forms using a computer-guided system to vary the composition and structure in order to optimize the product and the manufacturing process. The process is immediately scalable. An Expert System can be used with the method to recommend different compositions and designs of the prototypes, devices, dosage forms, tissue scaffold or other bioaffecting agents.
摘要翻译： 使用计算机引导系统以小批量或单独形式快速制造药物递送系统，医疗装置，药物剂型，组织支架或其它生物影响剂的不同原型的制造方法，以改变组合物和结构以优化产品 和制造过程。 该过程可以立即升级。 专家系统可以用于推荐原型，装置，剂型，组织支架或其它生物影响剂的不同成分和设计的方法。
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