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114 条记录 (耗时 0.034 秒)

    Implantable drug delivery device and methods
    1.
    发明授权
    Implantable drug delivery device and methods 有权

    公开(公告)号：US10532132B2

    公开(公告)日：2020-01-14

    申请号：US13910730

    申请日：2013-06-05

    申请人： Irene Sophie Tobias ,  Heejin Lee ,  Michael J. Cima ,  Jordan Dimitrakov

    发明人： Irene Sophie Tobias ,  Heejin Lee ,  Michael J. Cima ,  Jordan Dimitrakov

    IPC分类号： A61L31/06 ,  A61L31/16

    摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.

    Implantable device with intravesical tolerability and methods of treatment
    4.
    发明授权
    Implantable device with intravesical tolerability and methods of treatment 有权
    具有膀胱内耐受性和治疗方法的植入式装置

    公开(公告)号：US08679094B2

    公开(公告)日：2014-03-25

    申请号：US12972364

    申请日：2010-12-17

    申请人： Michael J. Cima ,  Heejin Lee

    发明人： Michael J. Cima ,  Heejin Lee

    IPC分类号： A61K9/22

    CPC分类号： A61M31/002 ,  A61F2/042 ,  A61K9/0034 ,  A61K9/2072 ,  A61K31/00 ,  A61K31/167 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/402 ,  A61L2300/602 ,  A61L2430/22 ,  A61M31/00

    摘要： Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1 N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.

    摘要翻译： 提供了可以在需要治疗的患者的膀胱内完全展开并且被患者良好耐受的膀胱内装置。 该装置可以包括具有保持形状的弹性体，其具有（i）提供膀胱内移动性的尺寸并且防止医疗装置通过尿道的排尿，以及（ii）排除医疗装置进入的尺寸，浮力或两者 输尿管孔。 当压缩到任何尺寸为3cm的最大尺寸的形状时，弹性体可发挥小于1N的最大作用力。 该装置可以包括用于膀胱内控制释放的药物，用于膀胱或区域组织的治疗。 还提供了治疗方法，包括在膀胱中选择需要治疗的患者，其中治疗的耐受性是主要关注的。

    Electrochemical actuator
    6.
    发明授权
    Electrochemical actuator 有权

    公开(公告)号：US08247946B2

    公开(公告)日：2012-08-21

    申请号：US12860771

    申请日：2010-08-20

    申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    IPC分类号： H01L41/08

    CPC分类号： F03G7/005 ,  H01M10/052

    摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

    Electrochemical actuator
    8.
    发明授权
    Electrochemical actuator 有权
    电化学执行器

    公开(公告)号：US08093781B2

    公开(公告)日：2012-01-10

    申请号：US12960224

    申请日：2010-12-03

    申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    IPC分类号： H01L41/08

    CPC分类号： F03G7/005 ,  H01M2/16 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/587 ,  H01M6/30 ,  H01M2004/021 ,  H01M2010/4292

    摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

    摘要翻译： 本发明提供涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输液泵）和药物递送装置。

    Device for controlling exposure of reservoir contents to surroundings
    9.
    发明授权
    Device for controlling exposure of reservoir contents to surroundings 有权
    用于控制水库内容物暴露于周围环境的装置

    公开(公告)号：US08016817B2

    公开(公告)日：2011-09-13

    申请号：US12348609

    申请日：2009-01-05

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott A. Uhland

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott A. Uhland

    IPC分类号： A61K9/22

    CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture.

    摘要翻译： 提供了包括衬底的Microchip器件; 在所述基板中的多个储存器，每个储存器限定内部容积; 以及储存器盖，其定位在从外部环境限定内部容积的每个储存器中或每个储存器中，所述储存器盖由在加热时经历相变的材料形成，其中所述内部容积可以在加热所述内部体积时与外界环境连通 储存器盖以使所述储存器盖发生相变和破裂。