公开(公告)号：US06217866B1

公开(公告)日：2001-04-17

申请号：US08487761

申请日：1995-06-07

申请人： Joseph Schlessinger ,  David Givol ,  Francoise Bellot ,  Richard Kris ,  George A. Ricca ,  Christopher Cheadle ,  Victoria J. South

发明人： Joseph Schlessinger ,  David Givol ,  Francoise Bellot ,  Richard Kris ,  George A. Ricca ,  Christopher Cheadle ,  Victoria J. South

IPC分类号： A61K39395

CPC分类号： C07K16/2863 ,  A61K38/00 ,  A61K39/395 ,  A61K33/24 ,  A61K31/70 ,  A61K2300/00

摘要： Hybridoma cell lines producing monoclonal antibodies specific to the human epidermal growth factor receptor are disclosed. The antibodies are capable of inhibiting the growth of human tumor cells expressing human epidermal growth factor receptors. Therapeutic uses of these monoclonal antibodies by themselves and in combination with anti-neoplastic agents are also disclosed.

摘要翻译： 公开了产生对人表皮生长因子受体特异性的单克隆抗体的杂交瘤细胞系。 抗体能够抑制表达人表皮生长因子受体的人肿瘤细胞的生长。 还公开了这些单克隆抗体本身和与抗肿瘤剂组合的治疗用途。

公开(公告)号：US5541109A

公开(公告)日：1996-07-30

申请号：US230047

申请日：1994-04-19

申请人： George H. Searfoss, III ,  Yuri D. Ivashchenko ,  Michael C. Jaye ,  Victoria J. South ,  Stephen M. French ,  Christopher Cheadle ,  George A. Ricca

发明人： George H. Searfoss, III ,  Yuri D. Ivashchenko ,  Michael C. Jaye ,  Victoria J. South ,  Stephen M. French ,  Christopher Cheadle ,  George A. Ricca

IPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C12N1/20 ,  C07H21/04 ,  C12N15/63

CPC分类号： C07K7/06 ,  C07K14/47 ,  C07K7/08

摘要： This invention provides a unique SH3 binding domain core motif of the sequence RPLPXXP and cDNA clones encoding proteins which interact with the SH3 domain of c-src, as well as the amino acid sequences which mediate this binding.Another embodiment of this invention is a method of identifying SH3-binding proteins and elucidating the sequences which mediate binding. This method may be used as an assay to select compounds which bind to this site and which inhibit or enhance the binding of the SH3 domain.

摘要翻译： 本发明提供了序列RPLPXXP的独特的SH3结合域核心基序和编码与c-src的SH3结构域相互作用的蛋白质的cDNA克隆，以及介导该结合的氨基酸序列。 本发明的另一个实施方案是鉴定SH3结合蛋白并阐明介导结合的序列的方法。 该方法可用作选择结合该位点并抑制或增强SH3结构域的化合物的测定法。