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    β-ketophosphonates
    1.
    发明授权
    β-ketophosphonates 有权
    β-酮膦酸盐

    公开(公告)号：US07112692B2

    公开(公告)日：2006-09-26

    申请号：US10485899

    申请日：2002-08-23

    申请人： Christopher John Harris ,  Alan Craig Smith ,  Julie Ann Salter

    发明人： Christopher John Harris ,  Alan Craig Smith ,  Julie Ann Salter

    IPC分类号： C07F9/02

    CPC分类号： C07F9/4059 ,  C07F9/4006

    摘要： A method for making β-ketophosphonates by reacting a trialkyl phosphonocarboxylate (such as triethyl phosphonoacetate) with an acyl halide (such as acetyl chloride) in a reaction involving ester formation, followed by decarboxylation, followed by purification. The reaction is run in a single solvent, which is not removed from the reaction mixture until the purification stage. Suitable solvents for this purpose include halogenated aromatic hydrocarbons (such as mono-chlorobenzene).

    摘要翻译： 通过在涉及酯形成的反应中使三烷基膦酰基羧酸酯（例如膦酰基乙酸三乙酯）与酰基卤（如乙酰氯）反应，随后进行纯化来制备β-酮磷酸酯的方法。 该反应在单一溶剂中进行，直至纯化阶段，其不从反应混合物中除去。 适用于此目的的溶剂包括卤代芳烃（如单氯苯）。

    Process for preparing phosphorodiamidites
    3.
    发明授权
    Process for preparing phosphorodiamidites 有权
    制备磷二亚胺的方法

    公开(公告)号：US07276620B2

    公开(公告)日：2007-10-02

    申请号：US10540160

    申请日：2003-12-18

    申请人： Christopher John Harris ,  Sheena Lesley Jackson ,  David James Wilson

    发明人： Christopher John Harris ,  Sheena Lesley Jackson ,  David James Wilson

    IPC分类号： C07F9/02

    CPC分类号： C07H21/00 ,  C07F9/2408

    摘要： A method of phosphorodiamidite production comprising the steps of reacting a phosphorus trihalide with a dialkyl amine in a polar solvent to form an intermediate compound. This intermediate compound is then subsequently reacted with an hydroxylalkyl compound and a dialkyl amine in the presence of a non-polar cosolvent. Following filtration to remove the solid by-product the two solvents form separate layers. This is advantageous as the upper, non-polar solvent, layer contains the high-purity phosphorodiamidite product.

    摘要翻译： 一种制备二亚磷酸二钙的方法，包括以下步骤：在极性溶剂中使三卤化磷与二烷基胺反应形成中间体化合物。 然后该中间体化合物随后在非极性助溶剂存在下与羟烷基化合物和二烷基胺反应。 过滤除去固体副产物后，两种溶剂形成分开的层。 这是有利的，因为上部非极性溶剂层含有高纯度的二亚磷酸钙产品。