公开(公告)号：US20230340008A1

公开(公告)日：2023-10-26

申请号：US17791799

申请日：2021-02-18

Applicant: Osaka University ,  Japan Represented by Director General of National Institute of Health Sciences

Inventor： Satoshi OBIKA ,  Takao YAMAGUCHI ,  Hibiki KOMINE ,  Takaya SUGIURA ,  Takao INOUE ,  Tokuyuki YOSHIDA

IPC: C07H21/02

CPC classification number: C07H21/02

Abstract: Disclosed are a bridged nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The bridged nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The bridged nucleoside also has excellent industrial productivity.

公开(公告)号：US20230146286A1

公开(公告)日：2023-05-11

申请号：US17918449

申请日：2021-04-15

Applicant: JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES ,  TOSOH CORPORATION

Inventor： Yoshiro SAITO ,  Ryosuke NAKAMURA ,  Noriaki ARAKAWA ,  Yasuo OHNO ,  Takashi IZUMI ,  Motonobu SATO ,  Takayoshi NISHIYA ,  Michiko AIHARA

IPC: G01N33/68 ,  G01N33/94

CPC classification number: G01N33/6893 ,  G01N33/94 ,  G01N2800/50 ,  G01N2800/56

Abstract: Biomarkers for diagnosing the disease activity, disease severity or disease type of severe cutaneous adverse drug reactions (SCARs) such as drug-induced hypersensitivity syndrome and Stevens-Johnson syndrome/toxic epidermal necrolysis are provided. Also provided is a method of testing SCARs, comprising measuring the expression of at least one protein selected from the group consisting of stratifin, TNF receptor superfamily member 8 (CD30/TNFRSF8), interleukin-1 receptor antagonist (IL-1Ra), and TNF receptor superfamily member 6B (DcR3/TNFRSF6B) in a sample derived from a subject.

公开(公告)号：US20220299523A1

公开(公告)日：2022-09-22

申请号：US17639226

申请日：2020-07-09

Applicant: JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES ,  NISSHIN SEIFUN GROUP INC.

Inventor： Hiroshi AKIYAMA ,  Hiroyuki KIKUCHI ,  Yusuke SEKI ,  Chisato ARIMOTO

IPC: G01N33/68 ,  C12Q1/37 ,  G01N30/06 ,  G01N30/72 ,  G01N33/10

Abstract: A highly sensitive allergen measurement method is provided. A method for detecting an allergen in a sample, comprising: treating a sample with a protease; and detecting presence or absence of an allergen marker in the enzyme-treated sample by analysis that utilizes chromatographic separation. The allergen comprises buckwheat and wheat.

公开(公告)号：US20240302250A1

公开(公告)日：2024-09-12

申请号：US18594095

申请日：2024-03-04

Applicant: SHIMADZU CORPORATION ,  DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES

Inventor： Takuya YOSHIOKA ,  Yosuke IWATA ,  Yusuke NAGAI ,  Katsumasa SAKAMOTO ,  Takuji SHODA ,  Tomoaki SAKAMOTO

IPC: G01N1/20 ,  G01N1/14 ,  G01N1/40

CPC classification number: G01N1/20 ,  G01N1/14 ,  G01N1/40

Abstract: A liquid sampling method in a flow monitoring system including a sampling section having a needle for performing sampling of a liquid, an analysis section that performs analysis of the liquid sampled by the sampling section, and a fluid supply section that supplies a sample fluid in a state of gas-liquid two-phase flow containing a gas phase and a liquid phase with the sample remaining in the state of gas-liquid two-phase flow. The liquid sampling method includes: a storage step of storing, in the storage container, a liquid phase contained in the sample fluid; a separation step of separating, from a liquid phase, a gas phase contained in the liquid phase stored in the storage container; and an injection step of suctioning, as a sample, the liquid phase stored in the storage container from a distal end of the needle after the separation step and injecting a predetermined amount of the sample into the analysis section through the injection port.

公开(公告)号：US20220175986A1

公开(公告)日：2022-06-09

申请号：US17440689

申请日：2020-03-11

Applicant: Ushio Denki Kabushiki Kaisha ,  Director General of National Institute of Health Sciences

Inventor： Hiroko MATSUMOTO ,  Makoto YAMANAKA ,  Fumitoshi TAKEMOTO ,  Kenji HATAKEYAMA ,  Yuji HAISHIMA ,  Yukiko KUDO ,  Yutaka KIKUCHI ,  Chie FUKUI

IPC: A61L2/10

Abstract: Disclosed herein is a method for decontaminating an object to be treated by reducing the activity of endotoxin in a simple manner. The decontamination method includes a step (a) of irradiating an object to be treated with ultraviolet light of a wavelength of less than 200 nm to reduce activity of endotoxin attached to the object to be treated.

公开(公告)号：US20230241144A1

公开(公告)日：2023-08-03

申请号：US18000019

申请日：2021-10-01

Applicant: THE KITASATO INSTITUTE ,  JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES ,  Matsuyama University ,  TOKIWA PHYTOCHEMICAL CO., LTD. ,  TSUMURA & CO.

Inventor： Toshihiko HANAWA ,  Sumiko HYUGA ,  Hiroshi ODAGUCHI ,  Yukihiro GODA ,  Masashi HYUGA ,  Masashi UEMA ,  Hiroshi ASAKURA ,  Nahoko UCHIYAMA ,  Yoshiaki AMAKURA ,  Morio YOSHIMURA ,  Jinwei YANG ,  Kazushige MIZOGUCHI

IPC: A61K36/13 ,  A61K9/00 ,  A61K31/352 ,  A61P31/14

CPC classification number: A61K36/13 ,  A61K9/0053 ,  A61K31/352 ,  A61P31/14

Abstract: Pharmaceutical preparations, Chinese herbal preparations, foods, and other compositions may contain, as an active ingredient, an ephedra extract, an ephedrine-alkaloid-free ephedra extract, or a polymercondensed tannin derived from an ephedra extract. Such compositions may be useful for preventing or treating COVID-19 infection (COVID-19). Such compositions are preferably provided in an orally ingestible form.

公开(公告)号：US20230124641A1

公开(公告)日：2023-04-20

申请号：US17800339

申请日：2021-02-17

Applicant: Osaka University ,  Japan as Represented by Director General of National Institute of health Sciences

Inventor： Satoshi OBIKA ,  Takao YAMAGUCHI ,  Yota SAKURAI ,  Chika YAMAMOTO ,  Kei SUGITA ,  Takao INOUE ,  Tokuyuki YOSHIDA

IPC: C07D493/08 ,  C07H21/04 ,  C07D239/10

Abstract: A cross-linked nucleoside of the present invention is a compound represented by the formula (I) below. The cross-linked nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The cross-linked nucleoside also has excellent industrial productivity.

公开(公告)号：US11078271B2

公开(公告)日：2021-08-03

申请号：US16473413

申请日：2017-12-25

Applicant: OSAKA UNIVERSITY ,  JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES

Inventor： Masuo Kondoh ,  Kiyohito Yagi ,  Akihiro Watari ,  Masayoshi Fukasawa ,  Minoru Tada ,  Jun Kunisawa

IPC: C07K16/18 ,  C07K16/28 ,  A61K39/395

Abstract: An object of the present invention is to provide a monoclonal antibody that recognizes an extracellular region of Claudin-2. A monoclonal antibody that specifically binds to an extracellular region of Claudin-2.