公开(公告)号：US4972848A

公开(公告)日：1990-11-27

申请号：US398220

申请日：1989-08-23

申请人： Edward D. Di Domenico ,  Christopher M. Hobot ,  Kenneth B. Stokes ,  Arthur J. Coury ,  Phong D. Doan ,  Richard D. Sandstrom

发明人： Edward D. Di Domenico ,  Christopher M. Hobot ,  Kenneth B. Stokes ,  Arthur J. Coury ,  Phong D. Doan ,  Richard D. Sandstrom

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/70 ,  A61K47/34 ,  A61M37/00 ,  A61N1/05

CPC分类号： A61K9/0024 ,  A61K9/2031 ,  A61K9/7007 ,  A61N1/0568 ,  A61N1/0573

摘要： A cardiac pacing lead or other stimulation lead carrying a steroid compounded within a polymer matrix. The steroid is dispersed in thermoplastic or thermoset polyurethane or polyurea forming monomers or prepolymers. The mixture is then chain extended by addition of the appropriate difunctional or multifunctional isocyanate, hydroxyl or amine curing agent to form a solid polymer. The resulting formulation is molded or cast into a desired shape, and incorporated in the distal end of a medical electrical lead, adjacent to or within the electrode. In a preferred embodiment, the medical lead employs an extendable helix which is screwed into body tissue, and the polymer containing the drug takes the form of a generally dimensionally stable annular member mounted to the lead, encircling the helix.

公开(公告)号：US5133422A

公开(公告)日：1992-07-28

申请号：US754326

申请日：1991-09-04

申请人： Arthur J. Coury ,  Patrick T. Cahalan ,  Edward D. Di Domenico, Jr. ,  Kenneth W. Keeney ,  John M. Swoyer

发明人： Arthur J. Coury ,  Patrick T. Cahalan ,  Edward D. Di Domenico, Jr. ,  Kenneth W. Keeney ,  John M. Swoyer

IPC分类号： B29C59/10 ,  B29C59/12 ,  B29C59/14

CPC分类号： B29C59/103 ,  B29C59/12 ,  B29C59/142 ,  A61N1/056 ,  B29K2083/00 ,  B29L2031/7534

摘要： Improved electrical leads provided by the surface treatment of silicone rubber tubing covering on implantable pulse generator, or IPG leads and the like by exposure of the silicone rubber to radio frequency glow discharge in a polymer forming or non-polymer forming gas at reduced pressure whereby improved slip properties are provided and binding between two or more of the leads in contact with each other is minimized.

摘要翻译： 通过在降低聚合物形成或非聚合物形成气体中的硅橡胶暴露于射频辉光放电，通过在植入式脉冲发生器上覆盖硅橡胶管的表面处理或IPG引线等而提供的改进的电引线，由此改善 提供滑动性能并且彼此接触的两个或更多个引线之间的结合被最小化。