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    Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio
    2.
    发明申请
    Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio 有权
    近紫外波长光子晶体生物传感器具有增强的表面与体积敏感性比

    公开(公告)号：US20080014632A1

    公开(公告)日：2008-01-17

    申请号：US11822303

    申请日：2007-07-02

    Applicant: Brian Cunningham ,  Nikhil Ganesh ,  Ian Block

    Inventor： Brian Cunningham ,  Nikhil Ganesh ,  Ian Block

    IPC: C12M1/34

    CPC classification number: G01N21/7743 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  B82Y20/00 ,  G01N21/253 ,  G01N21/33 ,  G01N33/54373 ,  G01N33/551 ,  G01N33/552 ,  G02B1/005

    Abstract: Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled-Wave Analysis simulations predict a more tightly confined resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These new biosensors can be fabricated in mass by replica molding. They are especially well suited for applications requiring the detection of small molecules or ultra-low analyte concentrations.

    Abstract translation: 基于在近紫外波长下操作的一维或二维光子晶体反射滤光片来公开生物传感器。 与先前制造的近红外光子晶体生物传感器相比，严格的耦合波分析模拟预测了该生物传感器表面更紧密的约束共振电场。 谐振电场的这种变化提供了表面灵敏度到体积敏感比的4.5倍以上的改进，因此能够提高吸附在生物传感器表面上的生物分子的检测分辨率。 这些新的生物传感器可以通过复制成型制成。 它们特别适用于需要检测小分子或超低分析物浓度的应用。

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