公开(公告)号：US5587370A

公开(公告)日：1996-12-24

申请号：US521253

申请日：1995-08-30

Applicant: Janis Hajimichael ,  Sandor Botar ,  Edit Bleicher ,  Laszlo Pap ,  Istvan Szekely ,  Katalin Marmarosi n ee Kellner ,  Janos Ori

Inventor： Janis Hajimichael ,  Sandor Botar ,  Edit Bleicher ,  Laszlo Pap ,  Istvan Szekely ,  Katalin Marmarosi n ee Kellner ,  Janos Ori

IPC: A01N43/713 ,  A01P7/02 ,  C07D257/08

CPC classification number: C07D257/08 ,  A01N43/713

Abstract: The invention relates to novel 1,2-dihydro-1,2,4,5-tetrazine derivatives of the formula (IV) ##STR1## wherein means fluorine, chlorine or bromine; andY stands for hydrogen or fluorine,as well as to a process for the preparation thereof. The compounds according to the invention have acaricidal, larvicidal and ovicidal effects.

Abstract translation: 本发明涉及新的式（Ⅳ）的1,2-二氢-1,2,4,5-四嗪衍生物，其中意指氟，氯或溴; 和Y代表氢或氟，以及其制备方法。 根据本发明的化合物具有杀螨，杀幼体和杀卵作用。

公开(公告)号：US5218117A

公开(公告)日：1993-06-08

申请号：US951448

申请日：1992-09-25

Applicant: Kalman Takacs ,  Iloma Kiss nee Ajzert ,  Istvan Hermecz ,  Janos Ori ,  Maria H. Pap ,  Zsolt Bencze ,  Peter Szekely Kormoczy ,  Maria Szabo ,  Judit Szeredy ,  Csaba Vertesi ,  Lorand Debreczeni ,  Jozsef Gaal ,  Zoltan Kapui

Inventor： Kalman Takacs ,  Iloma Kiss nee Ajzert ,  Istvan Hermecz ,  Janos Ori ,  Maria H. Pap ,  Zsolt Bencze ,  Peter Szekely Kormoczy ,  Maria Szabo ,  Judit Szeredy ,  Csaba Vertesi ,  Lorand Debreczeni ,  Jozsef Gaal ,  Zoltan Kapui

IPC: C07D217/16

CPC classification number: C07D217/16

Abstract: The invention relates to novel compounds of the general formula (I), ##STR1## The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

Abstract translation: 本发明涉及通式（I）的新化合物，（I）本发明的化合物拮抗收缩性介质的作用，例如， 组胺，乙酰胆碱或5-羟色胺; 它们显示抗过敏作用并具有抗炎作用。 因此，这些化合物可以治疗性地用作支气管扩张剂以及抗过敏药或抗炎药，特别是用于治疗支气管哮喘。

公开(公告)号：US5179089A

公开(公告)日：1993-01-12

申请号：US792255

申请日：1991-11-14

Applicant: Kalman Takacs ,  Iloma Kiss neAjzert ,  Istvan Hermecz ,  Janos Ori ,  Maria H. Pap ,  Zsolt Bencze ,  Peter S. Kormoczy ,  Maria Szabo ,  Judit Szeredy nee Varga ,  Csaba Vertesi ,  Lorand Debreczeni ,  Jozsef Gaal ,  Zoltan Kapui

Inventor： Kalman Takacs ,  Iloma Kiss neAjzert ,  Istvan Hermecz ,  Janos Ori ,  Maria H. Pap ,  Zsolt Bencze ,  Peter S. Kormoczy ,  Maria Szabo ,  Judit Szeredy nee Varga ,  Csaba Vertesi ,  Lorand Debreczeni ,  Jozsef Gaal ,  Zoltan Kapui

IPC: A61K31/47 ,  A61K31/33 ,  A61K31/472 ,  A61K31/4725 ,  A61P11/08 ,  A61P29/00 ,  A61P37/08 ,  C07D217/12 ,  C07D217/16 ,  C07D217/26

CPC classification number: C07D217/16

Abstract: The invention relates to novel compounds of the general formula (I), ##STR1## wherein R means hydrogen or a straight or branched chain C.sub.1-6 alkoxy group;R.sup.1 stands for hydrogen or a straight or branched chain C.sub.1-6 alkyl group;R.sup.2 represents hydrogen or a straight or branched chain C.sub.1-6 alkyl group;R.sup.3 means hydrogen, a straight or branched chain C.sub.1-6 alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C.sub.1-4 alkoxy group(s); or a C.sub.4-7 cycloalkyl group;R.sup.4 stands for hydrogen or a straight or branched chain C.sub.1-6 alkyl group optionally substituted by one or two hydroxyl and/or one or two straight or branched chain C.sub.1-4 alkoxy group(s); or a C.sub.4-7 cycloalkyl group; orR.sup.3 and R.sup.4 together with the nitrogen atom, to which they are attached form a 4 to 8-membered cyclic group of formula ##STR2## optionally substituted by one or two straight or branched chain C.sub.1-4 alkoxy and/or one or two straight or branched chain C.sub.1-4 alkyl group(s), where optionally an oxygen or sulfur atom or an N-R.sup.5 group may be substituted for a ring carbon atom, where R.sup.5 means hydrogen or a straight or branched chain C.sub.1-6 aliphatic alkyl group, the 4- to 8-membered cycle optionally being condensed with a benzene ring;R.sup.6 stands for hydrogen or a C.sub.1-10 acyl group and the salts and hydrates thereof as well as pharmaceutical compositions containing these compounds.The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.