公开(公告)号：US5218117A

公开(公告)日：1993-06-08

申请号：US951448

申请日：1992-09-25

Applicant: Kalman Takacs ,  Iloma Kiss nee Ajzert ,  Istvan Hermecz ,  Janos Ori ,  Maria H. Pap ,  Zsolt Bencze ,  Peter Szekely Kormoczy ,  Maria Szabo ,  Judit Szeredy ,  Csaba Vertesi ,  Lorand Debreczeni ,  Jozsef Gaal ,  Zoltan Kapui

Inventor： Kalman Takacs ,  Iloma Kiss nee Ajzert ,  Istvan Hermecz ,  Janos Ori ,  Maria H. Pap ,  Zsolt Bencze ,  Peter Szekely Kormoczy ,  Maria Szabo ,  Judit Szeredy ,  Csaba Vertesi ,  Lorand Debreczeni ,  Jozsef Gaal ,  Zoltan Kapui

IPC: C07D217/16

CPC classification number: C07D217/16

Abstract: The invention relates to novel compounds of the general formula (I), ##STR1## The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

Abstract translation: 本发明涉及通式（I）的新化合物，（I）本发明的化合物拮抗收缩性介质的作用，例如， 组胺，乙酰胆碱或5-羟色胺; 它们显示抗过敏作用并具有抗炎作用。 因此，这些化合物可以治疗性地用作支气管扩张剂以及抗过敏药或抗炎药，特别是用于治疗支气管哮喘。