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    Process for preparing N-sulphonyl-ureas
    1.
    发明授权
    Process for preparing N-sulphonyl-ureas 失效
    制备N-磺酰脲的方法

    公开(公告)号：US4954628A

    公开(公告)日：1990-09-04

    申请号：US317769

    申请日：1989-03-02

    Applicant: Gabor Besenyei ,  Sandor Nemeth ,  Laszlo Simandi ,  Maria Belak ,  Maria Szabo ,  Jozsef Dukai ,  Lajos Nagy ,  Elemer Tomordi ,  Csaba Soptei ,  Erzsebet E. Dioszegine

    Inventor： Gabor Besenyei ,  Sandor Nemeth ,  Laszlo Simandi ,  Maria Belak ,  Maria Szabo ,  Jozsef Dukai ,  Lajos Nagy ,  Elemer Tomordi ,  Csaba Soptei ,  Erzsebet E. Dioszegine

    IPC: C07D251/16 ,  B01J27/13 ,  B01J31/16 ,  C07B61/00 ,  C07C311/60 ,  C07D213/75 ,  C07D239/42 ,  C07D251/18 ,  C07D251/22 ,  C07D251/46 ,  C07D333/34 ,  C07D521/00

    CPC classification number: C07D521/00 ,  C07C311/60

    Abstract: The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) ##STR1## wherein Ar.sub.1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms,Ar.sub.2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C.sub.1-4 (halo)alkyl, C.sub.1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms.According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner.The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.

    Abstract translation: 本发明涉及一种制备通式（I）的磺酰脲的方法，其中Ar 1表示苯基，萘基或噻吩基，其衍生物被C 1-4烷基，C 1-4卤代烷基， （卤代）烷氧基羰基，（卤代）烷氧基，硝基，氰基以及卤素原子，Ar 2表示苯基，吡啶基，吡啶基或三嗪基，其衍生物被C 1-4（卤代）烷基， 卤代）烷氧基，氨基，O-酰基，O-芳基磺酰基，O-（取代的氨基甲酰基）基团以及卤素原子。 根据本发明，N-卤素芳基磺酰胺酸酯在羰基化催化剂，一氧化碳和芳族胺的存在下，任选地在相转移催化剂存在下反应，或N-卤素芳基磺酰胺盐与一氧化碳在存在下反应 的羰基化催化剂，并且任选地在相转移催化剂存在下，然后将所得反应混合物进一步与芳族胺反应或N-卤素 - 芳基胺 - 碱金属盐在芳基 - 磺酰胺存在下与 羰基化催化剂，一氧化碳和任选在相转移催化剂或胺，胺二卤代芳基磺酰胺存在下，在羰基化催化剂和一氧化碳的存在下反应，并将所得反应混合物以已知方式处理。 如此制备的磺酰脲是生物活性化合物，其用于制药工业和调节植物生长。

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