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    Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
    2.
    发明申请
    Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same 审中-公开
    可用于抑制血管渗漏，炎症和纤维化的化合物及其制备和使用方法

    公开(公告)号：US20060189534A1

    公开(公告)日：2006-08-24

    申请号：US11397286

    申请日：2006-04-04

    Applicant: Jian-xing Ma

    Inventor： Jian-xing Ma

    IPC: A61K38/17

    CPC classification number: A61K38/57

    Abstract: The present invention is directed to a method of inhibiting at least one of vascular leakage, angiogenesis, inflammation and fibrosis in an animal by administering to the animal an effective amount of a composition, wherein the composition is selected from the group consisting of kallistatin, fragments of kallistatin, analogs or derivatives of kallistatin, and combinations thereof.

    Abstract translation: 本发明涉及一种通过向动物施用有效量的组合物来抑制动物血管渗漏，血管生成，炎症和纤维化中的至少一种的方法，其中所述组合物选自卡立司他汀，片段 卡列斯汀，卡拉司他汀的类似物或衍生物及其组合。

    Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
    3.
    发明申请
    Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same 审中-公开
    可用于抑制血管渗漏，炎症和纤维化的化合物及其制备和使用方法

    公开(公告)号：US20050130897A1

    公开(公告)日：2005-06-16

    申请号：US11010794

    申请日：2004-12-13

    Applicant: Jian-xing Ma

    Inventor： Jian-xing Ma

    IPC: A61K38/17 ,  A61K38/55

    CPC classification number: A61K38/57

    Abstract: The present invention is directed to a method of inhibiting at least one of vascular leakage, angiogenesis, inflammation and fibrosis in an animal by administering to the animal an effective amount of a composition, wherein the composition is selected from the group consisting of kallistatin, fragments of kallistatin, analogs or derivatives of kallistatin, and combinations thereof.

    Abstract translation: 本发明涉及一种通过向动物施用有效量的组合物来抑制动物血管渗漏，血管生成，炎症和纤维化中的至少一种的方法，其中所述组合物选自卡立司他汀，片段 卡列斯汀，卡拉司他汀的类似物或衍生物及其组合。

    Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
    4.
    发明申请
    Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same 审中-公开
    可用于抑制血管渗漏，炎症和纤维化的化合物及其制备和使用方法

    公开(公告)号：US20050143300A1

    公开(公告)日：2005-06-30

    申请号：US10963115

    申请日：2004-10-12

    Applicant: Jian-Xing Ma

    Inventor： Jian-Xing Ma

    IPC: A61K38/18 ,  A61K38/48 ,  A61K38/57

    CPC classification number: A61K38/484 ,  A61K38/57

    Abstract: The present invention is directed to a method of inhibiting at least one of vascular leakage, inflammation and fibrosis in an animal by administering to the animal a vascular leakage inhibiting amount of a composition, wherein at a substantially higher amount the composition is effective in inhibiting angiogenesis, and wherein the anti-angiogenic activity of the composition is separate from the vascular leakage inhibiting activity of the composition. The animal experiencing at least one of vascular leakage, inflammation and fibrosis has a disease selected from the group consisting of diabetes, chronic inflammation, brain edema, arthritis, uvietis, macular edema, cancer, hyperglycemia, a kidney inflammatory disease, a disorder resulting in kidney fibrosis, a disorder of the kidney resulting in proteinuria, and combinations thereof. The composition capable of inhibiting at least one of vascular leakage, inflammation and fibrosis is selected from the group consisting of angiostatin, fragments of angiostatin, analogs or derivatives of angiostatin, pigment epithelium-derived factor, fragments of pigment epithelium-derived factor, analogs or derivatives of pigment epithelium-derived factor and combinations thereof.

    Abstract translation: 本发明涉及一种通过向动物施用血管渗漏抑制量的组合物来抑制动物的血管渗漏，炎症和纤维化中的至少一种的方法，其中以相当高的量组合物有效抑制血管生成 ，并且其中所述组合物的抗血管生成活性与组合物的血管渗漏抑制活性分开。 经历血管渗漏，炎症和纤维化中的至少一种的动物具有选自糖尿病，慢性炎症，脑水肿，关节炎，尿毒症，黄斑水肿，癌症，高血糖症，肾脏炎性疾病，导致 肾纤维化，肾脏疾病导致蛋白尿，及其组合。 能够抑制血管渗漏，炎症和纤维化中的至少一种的组合物选自血管抑素，血管抑素的片段，血管抑素的类似物或衍生物，色素上皮衍生因子，色素上皮衍生因子片段，类似物或 色素上皮衍生因子的衍生物及其组合。

    Compounds useful in treating diabetic microvascular complications and age-related macular degeneration
    6.
    发明申请
    Compounds useful in treating diabetic microvascular complications and age-related macular degeneration 审中-公开
    可用于治疗糖尿病微血管并发症和年龄相关性黄斑变性的化合物

    公开(公告)号：US20070298997A1

    公开(公告)日：2007-12-27

    申请号：US11703326

    申请日：2007-02-07

    Applicant: Jian-xing Ma

    Inventor： Jian-xing Ma

    IPC: A61K38/00 ,  A61P27/00

    CPC classification number: A61K38/57

    Abstract: The present invention is directed to a method of treating microvascular complications associated with diabetes and age-related macular degeneration. The methods include administering to an animal in need thereof an effective amount of a composition, wherein the composition is selected from the group consisting of kallistatin, fragments of kallistatin, analogs or derivatives of kallistatin, and combinations thereof.

    Abstract translation: 本发明涉及治疗与糖尿病和年龄相关性黄斑变性相关的微血管并发症的方法。 所述方法包括向有需要的动物施用有效量的组合物，其中所述组合物选自卡立司他胺，卡列斯汀的片段，卡列他汀的类似物或衍生物及其组合。

    Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
    8.
    发明申请
    Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same 审中-公开
    可用于抑制血管渗漏，炎症和纤维化的化合物及其制备和使用方法

    公开(公告)号：US20050250694A1

    公开(公告)日：2005-11-10

    申请号：US11010874

    申请日：2004-12-13

    Applicant: Jian-Xing Ma

    Inventor： Jian-Xing Ma

    IPC: A61K38/18 ,  A61K38/48 ,  A61K38/55

    CPC classification number: A61K38/484 ,  A61K38/57 ,  C12Y304/21007

    Abstract: The present invention is directed to a method of inhibiting at least one of vascular leakage, inflammation and fibrosis in an animal by administering to the animal a vascular leakage inhibiting amount of a composition, wherein at a substantially higher amount the composition is effective in inhibiting angiogenesis, and wherein the anti-angiogenic activity of the composition is separate from the vascular leakage inhibiting activity of the composition. The animal experiencing at least one of vascular leakage, inflammation and fibrosis has a disease selected from the group consisting of diabetes, chronic inflammation, brain edema, arthritis, uvietis, macular edema, cancer, hyperglycemia, a kidney inflammatory disease, a disorder resulting in kidney fibrosis, a disorder of the kidney resulting in proteinuria, and combinations thereof. The composition capable of inhibiting at least one of vascular leakage, inflammation and fibrosis is selected from the group consisting of angiostatin, fragments of angiostatin, analogs or derivatives of angiostatin, kringle 5 of plasminogen, fragments of kringle 5 of plasminogen, analogs or derivatives of kringle 5 of plasminogen, pigment epithelium-derived factor, fragments of pigment epithelium-derived factor, analogs or derivatives of pigment epithelium-derived factor and combinations thereof.

    Abstract translation: 本发明涉及一种通过向动物施用血管渗漏抑制量的组合物来抑制动物的血管渗漏，炎症和纤维化中的至少一种的方法，其中以相当高的量组合物有效抑制血管生成 ，并且其中所述组合物的抗血管生成活性与组合物的血管渗漏抑制活性分开。 经历血管渗漏，炎症和纤维化中的至少一种的动物具有选自糖尿病，慢性炎症，脑水肿，关节炎，尿毒症，黄斑水肿，癌症，高血糖症，肾脏炎性疾病，导致 肾纤维化，肾脏疾病导致蛋白尿，及其组合。 能够抑制血管渗漏，炎症和纤维化中的至少一种的组合物选自血管抑素，血管抑素的片段，血管抑素的类似物或衍生物，纤溶酶原的三联体5，纤溶酶原的三联体片段，类似物或衍生物 纤溶酶原，色素上皮衍生因子，色素上皮衍生因子片段，色素上皮衍生因子的类似物或衍生物及其组合。

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