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公开(公告)号：US20130225694A1
公开(公告)日：2013-08-29
申请号：US13775771
申请日：2013-02-25
IPC分类号： A61K31/04
CPC分类号： A61K31/04 , A61K9/0048 , A61K47/22
摘要： Nitrone-based compositions are disclosed that may be utilized for the prevention and treatment of a variety of ophthalmic diseases or conditions where RPE65 protein isomerohydrolase is implicated. Methods of production and use of said nitrone-based compositions, as well as pharmaceutical and ophthalmic compositions containing same, are disclosed.
摘要翻译： 公开了可以用于预防和治疗涉及RPE65蛋白质异构水解酶的各种眼科疾病或病症的基于硝基的组合物。 公开了所述基于硝酸的组合物的生产和使用方法，以及包含其的药物和眼用组合物。
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公开(公告)号：US06211259B1
公开(公告)日：2001-04-03
申请号：US09241550
申请日：1999-02-01
IPC分类号： C08G1865
CPC分类号： C08G18/6677 , C08G2101/0025 , C08G2101/005 , C08G2101/0083
摘要： The present invention includes new compositions for making polyurethane and polyurethane foam compositions. These compositions comprise the reaction product of an isocyanate A-Side and a B-Side comprising: (i) a polyol having a molecular weight of about 1000 g/mol or more, and having an average functionality of 2.0 or greater; (ii) a polyol having a Tg of about −80° C. or less, and having a molecular weight of about 1000 g/mol or more, and having an average functionality of 2.0 or greater; and(iii) a polyhydric alcohol having a molecular weight of about 90 g/mol or more, and having an average functionality of 3.0 or more. In the case of polyurethane foam compositions, the system also comprises water. The invention also includes processes for making the polyurethane and polyurethane foam compositions, as well as methods of adhering the same to cosmetic layers comprising thermoplastic, acrylic, and gel coat materials. The invention also includes articles made from these reinforced cosmetic layers.
摘要翻译： 本发明包括用于制备聚氨酯和聚氨酯泡沫组合物的新组合物。 这些组合物包含异氰酸酯A侧和B侧的反应产物，其包含：（i）分子量为约1000g / mol或更高，平均官能度为2.0或更大的多元醇; （ii）Tg为约-80℃或更低，分子量为约1000g / mol或更高，平均官能度为2.0或更大的多元醇; 和（iii）分子量为约90g / mol以上，平均官能度为3.0以上的多元醇。 在聚氨酯泡沫组合物的情况下，该体系还包括水。 本发明还包括制备聚氨酯和聚氨酯泡沫组合物的方法，以及将其粘附到包含热塑性，丙烯酸和凝胶涂层材料的化妆品层的方法。 本发明还包括由这些增强化妆品层制成的制品。
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公开(公告)号：US5447921A
公开(公告)日：1995-09-05
申请号：US409400
申请日：1995-03-24
IPC分类号： C08J9/02 , C08G18/00 , C08G18/63 , C08G18/65 , C08G18/68 , C08G101/00 , C08G18/02 , C08G18/04 , C08G18/18
CPC分类号： C08G18/68 , C08G18/635 , C08G18/657 , C08G2101/0025 , C08G2101/0041 , C08G2101/0083 , C08G2270/00
摘要： A thermosetting unsaturated polyester-polyurethane hybrid foam resin composition is made without significant blistering by using a 2-component catalyst system--one which initiates at room temperature and one which initiates at a temperature of at least 75.degree. C. and has a one-hour half-life temperature of at least 90.degree. C.; the composition has a room temperature stability of at least thirty days.
摘要翻译： 热固性不饱和聚酯 - 聚氨酯混合泡沫树脂组合物通过使用在室温下引发的2-组分催化剂体系和在至少75℃的温度下开始的一种，具有一小时 半衰期至少为90℃。 该组合物的室温稳定性至少为30天。
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公开(公告)号：US5409308A
公开(公告)日：1995-04-25
申请号：US201142
申请日：1994-02-24
CPC分类号： E05F1/1091 , E05D15/40 , E06B3/40 , E05Y2900/20 , Y10T16/53834
摘要： A cabinet is provided with a curved, upwardly-swinging door and interior shelves. The curved shelf door is mounted on a pair of opposed pivot arms which rotate on a horizontal axis. Each pivot arm is provided with a disk portion having a central boss and an arm portion tangent to the disk portion. The central boss engages a fixed stud at the side of the cabinet and provides a center pivot for each of the arms. A gas spring for each arm is provided, which is pivotably connected at one end to the arm and at the other end to a side wall of the cabinet. The gas spring serves a dual purpose of counterbalancing the door as it moves between an open and a closed position and opening the door unassisted once the user initiates movement of the door, this opening feature being very beneficial to seated and physically disabled users.
摘要翻译： 橱柜设有一个弯曲的向上摆动的门和内部货架。 弯曲的货架门安装在一对在水平轴上旋转的相对的枢转臂上。 每个枢转臂设置有具有中心凸台的圆盘部分和与圆盘部分相切的臂部分。 中心凸台与机柜侧面的一个固定螺栓接合，并为每个臂提供一个中心枢轴。 提供了用于每个臂的气弹簧，其一端可枢转地连接到臂上，另一端可枢转地连接到机柜的侧壁。 气弹簧用于当门在打开和关闭位置之间移动时平衡门的双重目的，并且一旦使用者启动门的移动就开启门，该开启特征对于坐着和身体残疾的使用者非常有益。
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公开(公告)号：US5050820A
公开(公告)日：1991-09-24
申请号：US312984
申请日：1989-02-21
申请人： Robert E. Anderson
发明人： Robert E. Anderson
CPC分类号： F16B3/00 , B64C1/12 , Y10T403/7066
摘要： The invention relates to an expansion fastener device that secures two interlocking members together. The device includes a parallelepiped receptacle having slits along opposite ends. The receptacle is inserted through the interlocking members and triple wedges are driven into the receptacle. The triple wedges includes a first wedge having tapers in the vertical direction and its insertion into receptacle causes only vertical expansion of the receptacle. A pair of horizontally tapered wedges are inserted into the receptacle alongside the first wedge and they cause only horizontal expansion of the receptacle. Utilization of the invention reduces stress points as created by conventional rivets.
摘要翻译： 本发明涉及将两个互锁构件固定在一起的膨胀紧固装置。 该装置包括具有相对端的狭缝的平行六面体插座。 插座通过互锁构件插入，三楔被驱动到插座中。 三楔形件包括在垂直方向上具有锥形的第一楔形物，并且其插入到容器中仅引起容器的垂直膨胀。 一对水平锥形的楔形物沿着第一楔形物插入到容器中，并且它们仅引起容器的水平膨胀。 本发明的利用减少了常规铆钉产生的应力点。
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公开(公告)号：US4909655A
公开(公告)日：1990-03-20
申请号：US306198
申请日：1989-02-06
申请人： Robert E. Anderson
发明人： Robert E. Anderson
CPC分类号： B29D99/0014 , B64C1/12 , F16B5/00 , B29K2105/08 , F16B3/00 , Y10T29/49922 , Y10T403/471 , Y10T403/472 , Y10T403/49 , Y10T403/4966
摘要： The invention relates to a joint for aircraft wing skins which have previously been connected to support substructures by rivets or other mechanical fasteners which create stress points and leakage points when aircraft wings are filled with fuel. The invention utilizes interleaved plies of a composite fabric to mechanically interlock the wing skin and support substructure. Use of the invention increases the structural integrity of the connection joint between wing skin and support substructure.
摘要翻译： 本发明涉及一种用于飞机机翼的接头，其先前已经通过铆钉或其它机械紧固件连接以支撑子结构，这些紧固件在飞机机翼充满燃料时产生应力点和泄漏点。 本发明利用复合织物的交错层来机械地互锁机翼皮肤和支撑子结构。 本发明的使用增加了机翼皮肤和支撑子结构之间的连接接头的结构完整性。
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公开(公告)号：US4826106A
公开(公告)日：1989-05-02
申请号：US16066
申请日：1987-02-18
申请人： Robert E. Anderson
发明人： Robert E. Anderson
CPC分类号： B29D24/007 , B64D29/00 , B64D33/04 , F02K1/82 , Y02T50/672 , Y10T428/24149
摘要： An aircraft cowl, and in particular a translating cowl, used as a component of a thrust reverser, formed of at least one one-piece bondment cured in a single operation. Preferably, a one-piece inner bondment and a one-piece outer bondment fastened together at a joining region. The bondments have constant density cores and tapered closures. Acoustically absorbing materials are part of the lay up for one of the bondments and are integrally cured therein.
摘要翻译： 用作推力反向器的组件的飞机罩，特别是平移罩，由在单次操作中固化的至少一个单件粘结形成。 优选地，在连接区域处固定在一起的单件内部粘合和一体式外部粘合。 粘合剂具有恒定密度的芯和锥形封闭。 声吸收材料是其中一个粘合物的叠层的一部分并且在其中整体固化。
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公开(公告)号：US4072848A
公开(公告)日：1978-02-07
申请号：US714574
申请日：1976-08-16
摘要： An electrical heating cable which limits power output once an established temperature limit is reached. The cable includes heating elements in the form of temperature-sensitive variable resistance elements electrically connected in parallel between two supply bases at spaced positions along the length of the buses. The heating elements not only serve to generate heat for heating but also undergo a substantial positive increase in resistivity when the temperature of the cable nears the established temperature limit. The increase in resistivity substantially reduces the heat-generating current in the cable to limit the power output to within established heat limits.
摘要翻译： 一旦达到建立的温度限制，就限制功率输出的电加热电缆。 电缆包括温度敏感的可变电阻元件形式的加热元件，该可变电阻元件在沿着总线长度的间隔位置处并联电连接在两个电源基座之间。 加热元件不仅用于产生加热的热量，而且当电缆的温度接近建立的温度极限时，电阻率也会显着增加。 电阻率的增加大大降低了电缆中的发热电流，将功率输出限制在已建立的热限度内。
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9.发明授权公开(公告)号：US08021874B2
公开(公告)日：2011-09-20
申请号：US12361163
申请日：2009-01-28
CPC分类号： C12P7/649 , A23L33/12 , A61K31/202 , C12P7/6427 , C12P7/6472 , Y02E50/13 , A61K2300/00
摘要： The present invention relates to processes for production of Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs). The present invention also relates to compositions (e.g., nutritional supplements and food products) containing such VLC-PUFAs. In one embodiment, the present invention is directed to methods for biosynthesis and production of the VLC-PUFAs described herein (particularly C28-C38 PUFAs, also referred to herein as supraenes or supraenoics) by the expression, in a production host cell, of the full or partial sequence(s) of Elovl4 DNA/mRNA nucleic acids or ELOVL4 protein sequences encoded thereby, from any species (prokaryotic or eukaryotic) for use in the biosynthesis, production, purification and utilization of VLC-PUFAs in particular by the elongation of C18-C26 saturated fatty acids and PUFAs. The composition of the invention comprises, in various embodiments, a dietary supplement, a food product, a pharmaceutical formulation, a humanized animal milk, an infant formula, a cosmetic item and a biodiesel fuel for example. A pharmaceutical formulation can include, but is not limited to: a drug for treatment of neurodegenerative disease, a retinal disorder, age related maculopathy, a fertility disorder, particularly regarding sperm or testes, or a skin disorder.
摘要翻译： 本发明涉及生产超长链多不饱和脂肪酸（VLC-PUFA）的方法。 本发明还涉及含有这种VLC-PUFA的组合物（例如，营养补充剂和食品）。 在一个实施方案中，本发明涉及通过在生产宿主细胞中表达在本文中描述的VLC-PUFA的生物合成和生产方法（特别是C28-C38 PUFA，本文也称为supraenes或supraenoics） Elovl4 DNA / mRNA核酸或由此编码的ELOVL4蛋白序列的完整或部分序列，用于生物合成，生产，纯化和利用VLC-PUFA的任何物种（原核或真核生物），特别是通过延长 C18-C26饱和脂肪酸和PUFA。 在各种实施方案中，本发明的组合物包含膳食补充剂，食品，药物制剂，人源化动物奶，婴儿配方食品，化妆品和生物柴油燃料。 药物制剂可以包括但不限于：用于治疗神经变性疾病，视网膜病症，年龄相关性黄斑病变，生育障碍，特别是关于精子或睾丸或皮肤病症的药物。
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公开(公告)号：US5172969A
公开(公告)日：1992-12-22
申请号：US756742
申请日：1991-09-09
申请人： Robert Reuter , Wallace C. Bullwinkle , Larry L. Hoff , Robert E. Anderson , Arkady Golynsky , Al Schmidt
发明人： Robert Reuter , Wallace C. Bullwinkle , Larry L. Hoff , Robert E. Anderson , Arkady Golynsky , Al Schmidt
CPC分类号： E05D3/18 , A47B96/00 , E05D11/1014 , E05D15/405 , E06B3/40 , E05Y2900/20 , Y10T16/5443
摘要： A cabinet is provided with a curved, upwardly-swinging door and interior shelves. The curved shelf door is mounted on a pair of opposed arms which rotate on a horizontal axis. Each arm is provided with two opposed, circularly arcuate slots and a central ellipsoidal slot, each slot engaging a fixed stud at the side of the cabinet. The ellipsoidal slot and its corresponding stud provide a center pivot for each of the arms. The arms are mounted inside the cabinet on opposed interior side walls. Lighting can be provided in a formed recess in the bottom of the cabinet. The cabinet can also be provided with plural internal shelves supported on planar brackets. The cabinet further can be provided with a pair of side-by-side doors and a center wall. Arms are mounted on each side of the center wall and adjacent the interior side walls of the cabinet, for separately mounting the doors.
摘要翻译： 橱柜设有一个弯曲的向上摆动的门和内部货架。 弯曲的货架门安装在一对在横轴上旋转的相对的臂上。 每个臂设有两个相对的圆弧形槽和中心椭圆形槽，每个槽与机柜侧面的固定螺栓啮合。 椭圆形狭槽及其对应的螺柱为每个臂提供中心枢轴。 手臂安装在机柜内相对的内侧壁上。 照明可以设置在机柜底部的成形凹槽中。 机柜也可以设置有多个支撑在平面支架上的内部货架。 机柜还可以设有一对并排门和中心墙。 臂安装在中心壁的每一侧并且靠近机柜的内侧壁，用于单独安装门。
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