公开(公告)号：US07063840B2

公开(公告)日：2006-06-20

申请号：US10179615

申请日：2002-06-24

申请人： Samuel Davis ,  Joanne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

发明人： Samuel Davis ,  Joanne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

IPC分类号： C07K16/24 ,  A61K39/395

CPC分类号： C07K14/515 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

公开(公告)号：US06645484B1

公开(公告)日：2003-11-11

申请号：US09689020

申请日：2000-10-12

申请人： Samuel Davis ,  JoAnne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

发明人： Samuel Davis ,  JoAnne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

IPC分类号： A61K3819

CPC分类号： C07K14/515 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

摘要翻译： 本发明提供了编码人TIE-2配体的分离的核酸分子。 此外，本发明提供了特异性结合人TIE-2配体的受体体。 本发明还提供了特异性结合人TIE-2配体的抗体。 本发明进一步提供人TIE-2的拮抗剂。 本发明还提供治疗组合物以及阻断血管生长的方法，促进新生血管形成的方法，促进表达TIE-2受体的细胞的生长或分化的方法，阻断生长或分化的方法 的表达TIE-2受体的细胞以及减弱或预防人类肿瘤生长的方法。

公开(公告)号：US6166185A

公开(公告)日：2000-12-26

申请号：US162437

申请日：1998-09-28

申请人： Samuel Davis ,  JoAnne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

发明人： Samuel Davis ,  JoAnne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K38/17 ,  A61K39/395 ,  A61K47/48 ,  A61K48/00 ,  A61K51/00 ,  A61P9/10 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07H21/04 ,  C07K20060101 ,  C07K14/47 ,  C07K14/515 ,  C07K14/705 ,  C07K16/28 ,  C07K19/00 ,  C12N20060101 ,  C12N5/06 ,  C12N5/10 ,  C12N15/00 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12N15/19 ,  C12N15/62 ,  C12N15/63 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24

CPC分类号： C07K14/515 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

摘要翻译： 本发明提供了编码人TIE-2配体的分离的核酸分子。 此外，本发明提供了特异性结合人TIE-2配体的受体体。 本发明还提供了特异性结合人TIE-2配体的抗体。 本发明进一步提供人TIE-2的拮抗剂。 本发明还提供治疗组合物以及阻断血管生长的方法，促进新生血管形成的方法，促进表达TIE-2受体的细胞的生长或分化的方法，阻断生长或分化的方法 的表达TIE-2受体的细胞以及减弱或预防人类肿瘤生长的方法。

公开(公告)号：US06433143B1

公开(公告)日：2002-08-13

申请号：US08817318

申请日：1999-09-16

申请人： Samuel Davis ,  Joanne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

发明人： Samuel Davis ,  Joanne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

IPC分类号： C07K1452

CPC分类号： C07K14/515 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body, which specifically binds a human TIE-2 ligand. The invention also provides an antibody that specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

摘要翻译： 本发明提供了编码人TIE-2配体的分离的核酸分子。 此外，本发明提供了特异性结合人TIE-2配体的受体体。 本发明还提供了特异性结合人TIE-2配体的抗体。 本发明进一步提供人TIE-2的拮抗剂。 本发明还提供治疗组合物以及阻断血管生长的方法，促进新生血管形成的方法，促进表达TIE-2受体的细胞的生长或分化的方法，阻断生长或分化的方法 的表达TIE-2受体的细胞以及减弱或预防人类肿瘤生长的方法。