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公开(公告)号：US11576932B2
公开(公告)日：2023-02-14
申请号：US16089809
申请日：2016-03-31
Applicant: Lion TCR Pte. Ltd.
Inventor： Antonio Bertoletti , Sarene Koh
IPC: A61K35/17 , C07K14/70 , C12N5/0783 , C07K14/725 , A61P31/20 , A61K39/29 , C07K14/02
Abstract: The present invention relates to T cells, in particular a non-activated T cell, comprising an exogenous nucleic acid encoding a T cell Receptor (TCR) specific for a virus. An embodiment of the invention is directed to a non-activated (resting) T cell expressing Hepatitis B virus (HBV) envelope s183-191 TCR capable of inhibiting viral replication and which shows reduced expression of perforins and/or granzymes in response to stimulation as compared to an activated T cell expressing the said TCR. Also encompassed are methods for producing such cells, compositions, pharmaceutical compositions and kits comprising such cells and medical uses thereof.
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公开(公告)号：US20190233497A1
公开(公告)日：2019-08-01
申请号：US16336000
申请日：2016-09-23
Applicant: Lion TCR Pte. Ltd.
Inventor： Antonio Bertoletti , Tan Anthony Tanoto , Sheau Fung Sarene Koh , Zack Ho
IPC: C07K14/725 , C07K14/005 , A61K35/17 , C12Q1/6881 , C12Q1/70
CPC classification number: C07K14/7051 , A61K35/17 , A61K38/00 , A61P31/00 , A61P31/20 , A61P35/00 , C07K14/005 , C12N2730/10122 , C12N2740/10043 , C12N2800/22 , C12Q1/6881 , C12Q1/6883 , C12Q1/6886 , C12Q1/706 , C12Q2600/106 , G01N33/56972 , G01N33/5761 , G01N2333/7051
Abstract: Hepatitis B Virus (HBV) antigen specific binding molecules, in particular T Cell Receptors (TCRs), TCR polypeptides and fragments thereof. The invention is also related to modified cells containing the TCRs, TCR polypeptides or fragments, pharmaceutical composition or kits including the same or methods of making or using the same as is described. In particular, the invention discloses TCRs or a fragments thereof, capable of binding to a peptide of a Hepatitis B Virus (HBV) Env polypeptide presented by an MHC class I molecule comprising an MHC class I σ-chain encoded by an HLA-Cw*08 allele.
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Patent Agency Ranking
公开(公告)号：US20190192566A1
公开(公告)日：2019-06-27
申请号：US16089809
申请日：2016-03-31
Applicant: Lion TCR Pte. Ltd.
Inventor： Antonio Bertoletti , Sarene Koh
IPC: A61K35/17 , C12N5/0783 , A61K39/29 , C07K14/02 , A61P31/20
CPC classification number: A61K35/17 , A61K39/292 , A61P31/20 , C07K14/02 , C07K14/7051 , C12N5/0638 , C12N2510/00
Abstract: The present invention relates to T cells, in particular a non-activated T cell, comprising an exogenous nucleic acid encoding a T cell Receptor (TCR) specific for a virus. An embodiment of the invention is directed to a non-activated (resting) T cell expressing Hepatitis B virus (HBV) envelope s183-191 TCR capable of inhibiting viral replication and which shows reduced expression of perforins and/or granzymes in response to stimulation as compared to an activated T cell expressing the said TCR. Also encompassed are methods for producing such cells, compositions, pharmaceutical compositions and kits comprising such cells and medical uses thereof.
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公开(公告)号：US12188016B2
公开(公告)日：2025-01-07
申请号：US16626395
申请日：2018-06-27
Inventor： Ernest Guccione , Dave Keng Boon Wee , Antonio Bertoletti
IPC: C12N15/11 , A61K31/7088 , A61K35/17 , A61P35/00 , C12N15/113
Abstract: The present invention relates to antisense oligonucleotides for modulating the function of a T cell, including antisense oligonucleotides that hybridise to IFN-γ, granzyme, perforin 1, PD-1, PRDM1, PD-L1, CD40LG, NDFIP1, PDCD1 LG2, REL, BTLA, CD80, CD160, CD244, LAG3, TIGIT, ADORA2A & TIM-3 RNAs. In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed is a method for further modifying the specificity of said T-cell by providing for a T cell receptor gene.
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公开(公告)号：US20230061817A1
公开(公告)日：2023-03-02
申请号：US17794379
申请日：2021-01-21
Applicant: LION TCR PTE. LTD.
Inventor： Antonio BERTOLETTI , Zi Zong HO , Sarene KOH , Anthony Tanoto TAN , Lu-En WAI
IPC: C07K14/725 , C12N15/10 , C12N15/89 , A61K35/17 , A61P31/20
Abstract: The invention provides T cell receptors (TCRs) that bind Hepatitis B virus (HBV) antigens. The present invention also provides methods of producing, screening and selecting the TCRs, therapeutic applications of the TCRs, and libraries of the TCRs.
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公开(公告)号：US11186624B2
公开(公告)日：2021-11-30
申请号：US16336000
申请日：2016-09-23
Applicant: Lion TCR Pte. Ltd.
Inventor： Antonio Bertoletti , Tan Anthony Tanoto , Sheau Fung Sarene Koh , Zack Ho
IPC: C07K14/725 , C12Q1/70 , C07K14/005 , A61P35/00 , A61P31/00 , A61P31/20 , C12Q1/6883 , G01N33/576 , C12Q1/6886 , G01N33/569 , A61K35/17 , C12Q1/6881 , A61K38/00
Abstract: Hepatitis B Virus (HBV) antigen specific binding molecules, in particular T Cell Receptors (TCRs), TCR polypeptides and fragments thereof. The invention is also related to modified cells containing the TCRs, TCR polypeptides or fragments, pharmaceutical composition or kits including the same or methods of making or using the same as is described. In particular, the invention discloses TCRs or a fragments thereof, capable of binding to a peptide of a Hepatitis B Virus (HBV) Env polypeptide presented by an MHC class I molecule comprising an MHC class I σ-chain encoded by an HLA-Cw*08 allele.
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公开(公告)号：US20200377883A1
公开(公告)日：2020-12-03
申请号：US16626395
申请日：2018-06-27
Inventor： Ernest GUCCIONE , Dave Keng Boon WEE , Antonio BERTOLETTI
IPC: C12N15/113 , A61K31/7088 , A61K35/17 , A61P35/00
Abstract: The present invention relates to antisense oligonucleotides for modulating the function of a T cell, including antisense oligonucleotides that hybridise to IFN-γ, granzyme, perforin 1, PD-1, PRDM1, PD-L1, CD40LG, NDFIP1, PDCD1 LG2, REL, BTLA, CD80, CD160, CD244, LAG3, TIGIT, ADORA2A & TIM-3 RNAs. In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed is a method for further modifying the specificity of said T-cell by providing for a T cell receptor gene.
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