公开(公告)号：US20110263543A1

公开(公告)日：2011-10-27

申请号：US13060959

申请日：2009-08-24

Applicant: Rajiv R. Sakhardande ,  Vithal Kulkarni ,  Nilesh Wagh ,  Manmohan Nimbalkar ,  Suhas M. Nadkarni

Inventor： Rajiv R. Sakhardande ,  Vithal Kulkarni ,  Nilesh Wagh ,  Manmohan Nimbalkar ,  Suhas M. Nadkarni

IPC: A61K9/28 ,  A61K31/635 ,  A61K31/41 ,  A61P29/00 ,  C07D403/10 ,  C07D233/64 ,  C07D233/61 ,  B29C67/24 ,  A61K31/4164

CPC classification number: C07D233/92 ,  C07D233/68 ,  C07D403/10

Abstract: Biphenyl compounds of Formula (I) and Formula (II), and their pharmaceutically acceptable salts or solvates or prodrugs, their pharmaceutical compositions, their use and process of preparation are provided. Compounds of Formula (I) and Formula (II) are disclosed to exhibit anti-inflammatory properties.

Abstract translation: 提供式（I）和式（II）的联苯化合物及其药学上可接受的盐或溶剂合物或前药，其药物组合物，其用途和制备方法。 公开了式（I）和式（II）的化合物以表现出抗炎性质。

公开(公告)号：US20050070586A1

公开(公告)日：2005-03-31

申请号：US10913121

申请日：2004-08-05

Applicant: Ashok Kumar ,  Rajesh Kumar Keshava Prasad Singh ,  Nalinakshya Panda ,  Abhay Upare ,  Manmohan Nimbalkar ,  Satish Soudagar ,  Ashvini Kumar Nand Kishore Saxena

Inventor： Ashok Kumar ,  Rajesh Kumar Keshava Prasad Singh ,  Nalinakshya Panda ,  Abhay Upare ,  Manmohan Nimbalkar ,  Satish Soudagar ,  Ashvini Kumar Nand Kishore Saxena

IPC: A61K31/4184 ,  C07D403/10 ,  C07D43/02

CPC classification number: A61K31/4184 ,  C07D403/10

Abstract: Improved processes using primary, secondary and tertiary alcohols and with safer mode of introduction of the reagent and reaction conditions are described. Further, the process of manufacture of Losartan potassium by use of alkali metal salt such as Potassium carbonate is disclosed. A process for preparation of the polymorphic Form I of Losartan potassium is also disclosed herein.

Abstract translation: 描述了使用伯醇，仲醇和叔醇以及更安全的引入试剂和反应条件的改进方法。 此外，公开了通过使用碱金属盐如碳酸钾制造氯沙坦钾的方法。 本文还公开了制备氯沙坦钾的多晶型I的方法。

公开(公告)号：US08236843B2

公开(公告)日：2012-08-07

申请号：US13060959

申请日：2009-08-24

Applicant: Rajiv R. Sakhardande ,  Vithal Kulkarni ,  Nilesh Wagh ,  Manmohan Nimbalkar ,  Suhas M. Nadkarni

Inventor： Rajiv R. Sakhardande ,  Vithal Kulkarni ,  Nilesh Wagh ,  Manmohan Nimbalkar ,  Suhas M. Nadkarni

IPC: A61K31/4174 ,  C07D233/64 ,  C07D233/66

CPC classification number: C07D233/92 ,  C07D233/68 ,  C07D403/10

Abstract: Biphenyl compounds of Formula (I) and Formula (II), and their pharmaceutically acceptable salts or solvates or prodrugs, their pharmaceutical compositions, their use and process of preparation are provided. Compounds of Formula (I) and Formula (II) are disclosed to exhibit anti-inflammatory properties.

Abstract translation: 提供式（I）和式（II）的联苯化合物及其药学上可接受的盐或溶剂合物或前药，其药物组合物，其用途和制备方法。 公开了式（I）和式（II）的化合物以表现出抗炎性质。

公开(公告)号：US20060281801A1

公开(公告)日：2006-12-14

申请号：US11405522

申请日：2006-04-18

Applicant: Ashok Kumar ,  Manmohan Nimbalkar ,  Sanjay Barve ,  Dattatray Metil ,  Rahul Kelkar ,  Bharat Shimpukade ,  Lavkesh Kushwaha

Inventor： Ashok Kumar ,  Manmohan Nimbalkar ,  Sanjay Barve ,  Dattatray Metil ,  Rahul Kelkar ,  Bharat Shimpukade ,  Lavkesh Kushwaha

IPC: A61K31/41 ,  C07D257/02

CPC classification number: C07D257/04

Abstract: The present invention relates to an improved process for the preparation of valsartan and its intermediates in substantially pure enantiomeric form. In particular, the present invention provides a process for preparing benzyl valsartan intermediate substantially free of organotin impurities. The valsartan produced from such benzyl valsartan intermediate requires significantly lower catalyst loading and has superior purity.

Abstract translation: 本发明涉及以基本上纯的对映体形式制备缬沙坦及其中间体的改进方法。 特别地，本发明提供了制备基本上不含有机锡杂质的苄基缬沙坦中间体的方法。 由这种苄基缬沙坦中间体生产的缬沙坦需要显着降低催化剂负载量并具有优异的纯度。

公开(公告)号：US06916935B2

公开(公告)日：2005-07-12

申请号：US10431847

申请日：2003-05-07

Applicant: Ashok Kumar ,  Rajeshkumar Singh ,  Nalinakshya Panda ,  Abhay Upare ,  Manmohan Nimbalkar ,  Satish Soudagar

Inventor： Ashok Kumar ,  Rajeshkumar Singh ,  Nalinakshya Panda ,  Abhay Upare ,  Manmohan Nimbalkar ,  Satish Soudagar

IPC: A61K31/4184 ,  C07D403/10 ,  C07D257/00

CPC classification number: C07D403/10 ,  A61K31/4184

Abstract: A process for the synthesis of Losartan Potassium by reacting Trityl Losartan in a primary alcohol with potassium tertiary alkoxide.

Abstract translation: 通过使三苯甲基氯沙坦与伯醇与叔醇钾反应合成氯沙坦钾的方法。