公开(公告)号：US20050037384A1

公开(公告)日：2005-02-17

申请号：US10824946

申请日：2004-04-15

申请人： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

发明人： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

IPC分类号： G01N21/03 ,  G01N21/35 ,  G01N21/86 ,  C12Q1/68 ,  C12M1/34

CPC分类号： G01N21/8483 ,  G01N21/0303 ,  G01N21/35 ,  G01N21/3577

摘要： Disclosed herein is a system for estimating the concentration of an analyte in a material sample. The system comprises a source of electromagnetic radiation; a detector positioned to detect radiation emitted by the source, so that the source and the detector define an optical path therebetween; and a sample element configured to be positioned in the optical path. The sample element comprises a sample chamber at least partially defined by opposed first and second windows which are substantially transmissive of at least a portion of the radiation emitted by the source, and which define an optical pathlength through the sample element. The sample chamber has an internal volume of less than 2 microliters. When the material sample is positioned in the sample chamber and the sample chamber is positioned in the optical path, the system computes estimated concentrations of the analyte in the material sample. The estimated concentrations deviate from corresponding actual concentrations of the analyte in the material sample by an RMS error of less than 15 mg/dL.

摘要翻译： 本文公开了一种用于估计材料样品中分析物浓度的系统。 该系统包括电磁辐射源; 检测器，定位成检测由源发射的辐射，使得源和检测器在其间限定光路; 以及构造成定位在光路中的样本元件。 样品元件包括至少部分地由相对的第一和第二窗口限定的样品室，其基本上透射由源发射的辐射的至少一部分，并且通过样品元件限定光程长度。 样品室的体积小于2微升。 当材料样品定位在样品室中并且样品室位于光路中时，系统计算材料样品中分析物的估计浓度。 估计的浓度偏离材料样品中分析物的相应实际浓度，RMS误差小于15 mg / dL。