公开(公告)号：US6133299A

公开(公告)日：2000-10-17

申请号：US23016

申请日：1993-02-25

申请人： Charles Price Taylor, Jr. ,  Mark Lawrence Weber

发明人： Charles Price Taylor, Jr. ,  Mark Lawrence Weber

IPC分类号： A61K31/165 ,  A61K31/415 ,  A61K31/425 ,  A61K31/44 ,  A61K31/53 ,  A61K31/55

CPC分类号： A61K31/7004 ,  A61K31/165 ,  A61K31/415 ,  A61K31/425 ,  A61K31/44 ,  A61K31/53 ,  A61K31/55

摘要： The instant invention is novel uses of known N-(2,6-disubstituted phenyl)-N'-3- and 4-pyridinyl ureas and pharmaceutically acceptable acid addition salts thereof. Such compounds as N-(2-chloro-6-methylphenyl)-N'-4-pyridinyl urea monohydrochloride or N-(2,3-dichlorophenyl)-N'-4-pyridinyl urea are used for treating neurodegenerative disorders, perinatal asphyxia, Alzheimer's disease, Huntington's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. The instant invention is similar novel uses of known anticonvulsant compounds as ralitoline, phenytoin, lamotrigine, tetrodotoxin, lidocaine, and carbamazepine.

摘要翻译： 本发明是已知的N-（2,6-二取代苯基）-N'-3-和4-吡啶基脲及其药学上可接受的酸加成盐的新用途。 此类化合物如N-（2-氯-6-甲基苯基）-N'-4-吡啶基脲单盐酸盐或N-（2,3-二氯苯基）-N'-4-吡啶基脲用于治疗神经变性疾病，围产期窒息 ，阿尔茨海默氏病，亨廷顿病，帕金森病和肌萎缩性侧索硬化。 本发明是已知的抗惊厥化合物的类似新颖用途，如雷洛芬，苯妥英，拉莫三嗪，河豚毒素，利多卡因和卡马西平。