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公开(公告)号:US20190247338A1
公开(公告)日:2019-08-15
申请号:US16342429
申请日:2017-10-16
发明人: Hiromi WADA
IPC分类号: A61K31/165 , A61K31/506 , A61P35/02 , A61K9/00
CPC分类号: A61K31/165 , A61K9/0053 , A61K31/506 , A61P35/02 , A61P43/00
摘要: The present application provides a pharmaceutical composition for use in treatment or remission of patients with chronic myelogenous leukemia, wherein the composition comprises, as active ingredients, (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoylamino]-4-methylpentanoic acid or a pharmacologically acceptable salt thereof, and 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide or a pharmacologically acceptable salt thereof, both of which are used at low doses.
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公开(公告)号:US20190247336A1
公开(公告)日:2019-08-15
申请号:US15999705
申请日:2018-08-20
发明人: Manoj Maniar
IPC分类号: A61K31/165 , A61K9/00 , A61K45/06 , A61K31/325 , A61K31/245 , A61K31/045 , A61K31/18 , A61K31/17 , A61K31/167 , A61K31/16 , A61K31/24
CPC分类号: A61K31/165 , A61K9/0019 , A61K31/045 , A61K31/16 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/245 , A61K31/325 , A61K45/06 , A61K2300/00
摘要: Formulations and methods are provided for the treatment of pain, and neuropathic pain in particular. The formulations are eutectic mixtures of a capsaicinoid and a local anesthetic agent and/or an anti-pruritic agent.
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3.
公开(公告)号:US20190233405A1
公开(公告)日:2019-08-01
申请号:US16303641
申请日:2017-05-23
发明人: Zhiqiang Feng , Xiaoguang Chen , Yang Yang , Chuan Zhou , Fangfang Lai , Ming Ji , Xiaofeng Jin , Nina Xue , Yi Zheng , Hao Chen , Ling Li
IPC分类号: C07D407/12 , A61P35/00 , C07C235/34 , C07C233/36 , C07C229/36 , C07C211/29 , C07D265/30 , C07D221/00
CPC分类号: C07D407/12 , A61K31/165 , A61K31/277 , A61K31/36 , A61P35/00 , C07C211/29 , C07C229/36 , C07C233/36 , C07C235/34 , C07C255/54 , C07C311/05 , C07D221/00 , C07D265/30 , C07D319/18 , C07D405/12
摘要: The present invention discloses a phenylate derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to phenylate derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.
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4.
公开(公告)号:US20190231748A1
公开(公告)日:2019-08-01
申请号:US16379779
申请日:2019-04-09
发明人: Zhongming Zeng , Wenyong Zhang , Kongyuan Wu
IPC分类号: A61K31/4164 , A61P31/10 , A61K31/165 , A61P31/04 , A61P15/02 , A61K9/00
CPC分类号: A61K31/4164 , A61K9/0034 , A61K9/06 , A61K9/08 , A61K31/165 , A61K31/19 , A61K31/198 , A61K31/401 , A61K31/70 , A61K31/702 , A61K45/06 , A61P15/02 , A61P31/04 , A61P31/10 , Y02A50/473
摘要: The present disclosure relates to an antimicrobial agent combination for use in preparing a composition for vagina. The combination of antimicrobial agents is strong in inhibiting against Escherichia coli, and/or Staphylococcus aureus, and/or Candida. The present disclosure also relates to a composition for vagina, which has a strong inhibition effect on Escherichia coli, and/or Staphylococcus aureus, and/or Candida. Being used in the vagina, the composition can promote the restoration of beneficial lactobacillus, increase the acidity of the vagina. It is suitable for modulating microecology and balancing microorganism in the vagina, and selectively decontaminating vagina.
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公开(公告)号:US20190216790A1
公开(公告)日:2019-07-18
申请号:US16336424
申请日:2017-10-12
IPC分类号: A61K31/4462 , A61P17/04 , A61K9/00 , A61K31/17 , A61P17/06
CPC分类号: A61K31/4462 , A61K9/0019 , A61K31/05 , A61K31/165 , A61K31/17 , A61K31/175 , A61K31/19 , A61K31/341 , A61K31/495 , A61P17/04 , A61P17/06
摘要: The present disclosure provides compositions and methods for treating chronic itch.
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公开(公告)号:US20190209589A1
公开(公告)日:2019-07-11
申请号:US16361556
申请日:2019-03-22
发明人: Jonathan Leis , Carol Carter
IPC分类号: A61K31/65 , A61K31/437 , A61K31/415 , A61K31/165 , A61K31/4439 , A61K31/4035 , A61K31/53
CPC分类号: A61K31/65 , A61K31/165 , A61K31/4035 , A61K31/415 , A61K31/437 , A61K31/4439 , A61K31/53
摘要: A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
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7.
公开(公告)号:US20190201371A1
公开(公告)日:2019-07-04
申请号:US16050038
申请日:2018-07-31
申请人: Mcrobion Corporation
IPC分类号: A61K31/29 , A61K31/426 , A61K31/095 , A61K33/245 , A61K38/14 , A61K31/7042 , A61K9/14 , A61K31/65 , A61K31/165 , A61K9/00 , A61K31/496 , A61K45/06 , A61K31/7036 , A61K31/704
CPC分类号: A61K31/29 , A61K9/0014 , A61K9/145 , A61K31/095 , A61K31/165 , A61K31/426 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K31/704 , A61K31/7042 , A61K33/245 , A61K38/14 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00
摘要: Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and/or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.
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公开(公告)号:US20190194124A1
公开(公告)日:2019-06-27
申请号:US16307702
申请日:2017-05-26
IPC分类号: C07C237/08 , A61K45/06 , A61K31/165 , A61K31/416 , C07D231/56 , C07D205/04 , A61K31/397 , A61K31/40 , C07D207/09 , A61P35/00 , A61K31/445 , C07D211/60 , C07D211/76 , A61K31/45 , C07C233/31 , C07D233/64 , A61K31/417
CPC分类号: C07C237/08 , A61K31/165 , A61K31/397 , A61K31/40 , A61K31/416 , A61K31/4164 , A61K31/417 , A61K31/445 , A61K31/45 , A61K45/06 , A61P35/00 , C07B2200/07 , C07C233/31 , C07C237/22 , C07C259/06 , C07D205/04 , C07D207/09 , C07D207/16 , C07D211/60 , C07D211/76 , C07D211/78 , C07D231/56 , C07D233/64 , C12Q1/68 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , A61K2300/00
摘要: Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.
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公开(公告)号:US20190192536A1
公开(公告)日:2019-06-27
申请号:US16119161
申请日:2018-08-31
申请人: Allergan, Inc.
发明人: James Chang , Patrick Hughes , Chin-Ming Chang
IPC分类号: A61K31/5575 , A61K9/107 , A61K9/00 , A61K9/16 , B01J13/06 , A61K47/34 , A61K31/165 , A61K9/14 , B01J13/04
CPC分类号: A61K31/5575 , A61K9/0048 , A61K9/0051 , A61K9/107 , A61K9/1075 , A61K9/146 , A61K9/1647 , A61K9/1694 , A61K31/165 , A61K47/34 , B01J13/04 , B01J13/06
摘要: Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.
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公开(公告)号:US20190183793A1
公开(公告)日:2019-06-20
申请号:US16155571
申请日:2018-10-09
发明人: Indu Muni , Naomi Vishnupad
IPC分类号: A61K9/08 , A61K31/4422 , A61P29/00 , A61P19/02 , A61K31/496 , A61P31/00 , A61K31/403 , A61K31/165 , A61K9/00 , A61K31/4709
CPC分类号: A61K9/08 , A61K9/0053 , A61K9/0095 , A61K31/165 , A61K31/403 , A61K31/4422 , A61K31/4709 , A61K31/496 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/36 , A61P19/02 , A61P29/00 , A61P31/00
摘要: The use of oral colchicine solutions in combination with other therapeutics, while minimizing toxic drug to drug interactions are described herein. Related compositions are also provided.
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