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公开(公告)号：US20240302348A1
公开(公告)日：2024-09-12
申请号：US18025883
申请日：2021-09-13
申请人： Medimmune Limited
发明人： Guenter Schmidt , Nicolas Brieu , Andreas Spitzmueller , Ansh Kapil , Tze Tan , Philipp Wortmann
CPC分类号： G01N33/5011 , G16B15/30
摘要： The present invention relates to a method for predicting how a cancer patient will respond to an antibody drug conjugate (ADC) therapy involving computing a predictive response score based on single-cell ADC scores for each cancer cell. For each cancer cell, a single-cell ADC score is computed based on the staining intensities of the dye in the membrane and cytoplasm of the cancer cell and in the membranes and cytoplasms of neighboring cancer cells. The present invention also relates to predicting a response of a cancer patient to ADC therapy by aggregating all single-cell ADC scores of the tissue sample using a statistical operation, and the subsequent treatment of cancer with related antibody-drug conjugates.
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公开(公告)号：US20240294619A1
公开(公告)日：2024-09-05
申请号：US18604668
申请日：2024-03-14
申请人： MedImmune Limited
发明人： Maria Groves , Suzanne Gustavsson , Kina Höglund , Chris Lloyd , Adrian Nickson , Camilla Niva , Sylvia Simon , David Lowne , Fraser Welsh , Per-Ola Freskgärd
IPC分类号： C07K16/18 , A61K38/17 , A61K39/00 , A61K39/395 , A61P25/28
CPC分类号： C07K16/18 , A61P25/28 , A61K38/1716 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/60 , C07K2317/622 , C07K2317/92
摘要： Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
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公开(公告)号：US20240262902A1
公开(公告)日：2024-08-08
申请号：US18403043
申请日：2024-01-03
申请人： MedImmune Limited
发明人： Darren Schofield , Matthew Alexander Sleeman , Iain Patrick Chessell , Jonathan Hatcher , David Lowe
IPC分类号： C07K16/22 , A61K39/00 , C07K14/48 , C07K14/705 , C07K14/715
CPC分类号： C07K16/22 , C07K14/48 , C07K14/70578 , C07K14/7151 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/35
摘要： This disclosure provides compositions and methods for controlling pain. In particular the disclosure provides a method for controlling pain comprising co-administration of an NGF antagonist and a TNFα antagonist. The NGF antagonist and the TNFα antagonist can be separate molecules or part of a multifunctional polypeptide, e.g., a multispecific binding molecule that comprises an NGF antagonist domain and a TNFα antagonist domain. This disclosure also provides multifunctional polypeptides, e.g., multispecific binding molecules, comprising an NGF antagonist domain, and a TNFα antagonist domain. The method provides improved pain control. Administration of an NGF antagonist and a TNFα antagonist as provided herein can control pain in the subject more effectively than an equivalent amount of the NGF antagonist or the TNFα antagonist administered alone.
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公开(公告)号：US20240101712A1
公开(公告)日：2024-03-28
申请号：US18451751
申请日：2023-08-17
申请人： Medimmune Limited
发明人： Andrew BUCHANAN , Sven Nylander , Mark Penney , Philip Newton , Feenagh Keyes , Tord Inghardt
IPC分类号： C07K16/44 , C07D487/04
CPC分类号： C07K16/44 , C07D487/04 , A61K2039/505 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The disclosure generally provides antibodies and antigen binding fragments of antibodies that bind ticagrelor and metabolites of ticagrelor. The disclosure also provides compositions comprising the antibodies, nucleic acid molecules encoding the antibodies, methods of treating a patient comprising administering the antibodies, and methods of making and using the antibodies.
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公开(公告)号：US11897949B2
公开(公告)日：2024-02-13
申请号：US17333291
申请日：2021-05-28
申请人： MedImmune Limited
发明人： Darren Schofield , Matthew Alexander Sleeman , Iain Patrick Chessell , Jonathan Hatcher , David Lowe
IPC分类号： C07K16/22 , C07K14/705 , C07K14/18 , A61K39/00 , C07K14/715 , C07K14/48
CPC分类号： C07K16/22 , C07K14/48 , C07K14/70578 , C07K14/7151 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/35
摘要： This disclosure provides compositions and methods for controlling pain. In particular the disclosure provides a method for controlling pain comprising co-administration of an NGF antagonist and a TNFα antagonist. The NGF antagonist and the TNFα antagonist can be separate molecules or part of a multifunctional polypeptide, e.g., a multispecific binding molecule that comprises an NGF antagonist domain and a TNFα antagonist domain. This disclosure also provides multifunctional polypeptides, e.g., multispecific binding molecules, comprising an NGF antagonist domain, and a TNFα antagonist domain. The method provides improved pain control. Administration of an NGF antagonist and a TNFα antagonist as provided herein can control pain in the subject more effectively than an equivalent amount of the NGF antagonist or the TNFα antagonist administered alone.
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公开(公告)号：US11845782B2
公开(公告)日：2023-12-19
申请号：US17528378
申请日：2021-11-17
申请人： MedImmune Limited
发明人： Weidong Hao , Andrew Garcia , Changshou Gao , Isabelle Sermadiras
CPC分类号： C07K14/64 , A61K9/0019 , A61P9/04 , A61K38/00 , C07K2319/30
摘要： The present invention relates to Relaxin fusion polypeptides, in particular to Relaxin 2 fusion polypeptides and uses thereof. Thus, the invention provides Relaxin fusion polypeptides, nucleic acid molecules, vectors, host cells, pharmaceutical compositions and kits comprising the same and uses of the same including methods of treatment. The polypeptides and compositions of the invention may be useful, in particular, in the treatment of cardiovascular diseases, for example for the treatment of heart failure.
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公开(公告)号：US20230372528A1
公开(公告)日：2023-11-23
申请号：US18248335
申请日：2021-10-14
CPC分类号： A61K47/6889 , A61K47/549 , A61K47/6855 , A61K47/6803 , A61P35/00
摘要： This disclosure relates to glycoconjugates comprising glycosylated cell-binding agents conjugated to pyrrolobenzodiazepine (PBD) payloads. Glycoconjugates of particular interest include conjugates where the cell-binding agent is an antibody and the payload comprises a cytotoxic pyrrolobenzodiazepine (PBD) moiety, with the PBD moiety conjugated to the antibody via an oligosaccharide linker. The disclosure also relates to methods for preparing the glycoconjugates, along with methods for their use.
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公开(公告)号：US11813335B2
公开(公告)日：2023-11-14
申请号：US17484467
申请日：2021-09-24
IPC分类号： A61K47/68 , A61P35/00 , A61K31/5517 , A61K45/06 , C07D519/00 , C07K16/28
CPC分类号： A61K47/6849 , A61K31/5517 , A61K45/06 , A61K47/6803 , A61P35/00 , C07D519/00 , C07K16/2863 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565
摘要： A conjugate of formula (I):
Ab-(DL)p (I)
wherein:
Ab is an antibody that binds to AXL;
DL is-
公开(公告)号：US11795225B2
公开(公告)日：2023-10-24
申请号：US17471723
申请日：2021-09-10
申请人： MedImmune Limited
发明人： Krista Lynne Kinneer , Gareth Charles Davies , David Gareth Rees , Jennifer Louise Percival-Alwyn , John Edward Andrews , Jon Chesebrough
CPC分类号： C07K16/2827 , A61K47/6803 , A61K47/6855 , A61P35/00 , C07K16/3015
摘要： The present invention relates to binding molecules (e.g. antibodies) for the treatment of cancer, and related antibody-drug conjugates.
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公开(公告)号：US20230285580A1
公开(公告)日：2023-09-14
申请号：US18056082
申请日：2022-11-16
IPC分类号： A61K47/68 , C07K16/28 , A61P35/00 , A61K31/5517
CPC分类号： A61K47/6803 , A61K31/5517 , A61P35/00 , C07K16/2866
摘要： This disclosure relates to antibody conjugates comprising antibodies that bind specifically to the Interleukin-13 receptor subunit alpha-2 (IL-13Rα2) protein, conjugated to cytotoxic warheads, and associated uses.
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