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公开(公告)号:US20190194291A1
公开(公告)日:2019-06-27
申请号:US16184147
申请日:2018-11-08
发明人: Peter Bruenker , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Ekkehard Moessner , Pablo Umana , Maria Amann , Christina Claus , Wei Xu
IPC分类号: C07K14/705 , C07K16/40 , C07K16/28 , C07K16/30
CPC分类号: C07K14/70578 , A61K39/395 , A61K47/6813 , A61K47/6835 , C07K14/70575 , C07K14/7151 , C07K16/14 , C07K16/241 , C07K16/2803 , C07K16/3007 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/92 , C07K2319/30
摘要: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) one Fab domain capable of specific binding to a target cell antigen, (b) a Fc domain composed of a first and a second subunit capable of stable association, and (c) a first polypeptide comprising two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and a second polypeptide comprising one ectodomain of said TNF ligand family member or a fragment thereof, wherein the first polypeptide is fused at its N-terminus to the C-terminus of one of the subunits of the Fc domain and wherein the second polypeptide is fused at its N-terminus to the C-terminus of the other subunit of the Fc domain, wherein the TNF family ligand trimer-containing antigen binding molecule is monovalent for the binding to the target cell antigen.
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公开(公告)号:US10010626B2
公开(公告)日:2018-07-03
申请号:US14997827
申请日:2016-01-18
申请人: Immunwork Inc.
发明人: Tse-Wen Chang , Hsing-Mao Chu , Chun-Yu Lin
IPC分类号: A61K39/00 , A61K39/44 , A61K47/18 , A61K47/30 , A61K47/42 , A61K47/48 , A61K31/4745 , A61K31/537 , A61K31/739 , C07K16/32 , C07K16/18 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/46 , C07K14/655 , C07K14/715 , C07K14/485 , A61K31/397 , A61K31/4709 , A61K31/4545
CPC分类号: A61K47/6803 , A61K31/397 , A61K31/4545 , A61K31/4709 , A61K31/4745 , A61K31/537 , A61K31/739 , A61K47/58 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/6801 , A61K47/6843 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K51/065 , A61K51/088 , A61K2039/505 , C07K14/485 , C07K14/655 , C07K14/705 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/94 , C07K2319/30 , C07K2319/32 , C07K2319/33
摘要: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
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公开(公告)号:US09934937B2
公开(公告)日:2018-04-03
申请号:US14489108
申请日:2014-09-17
IPC分类号: C07K14/24 , H01J37/22 , C07K14/00 , C07K14/36 , C07K14/47 , C07K14/715 , C07K19/00 , H01J37/20 , H01J37/295 , G01N33/68 , H01J37/26
CPC分类号: H01J37/222 , C07K14/001 , C07K14/24 , C07K14/36 , C07K14/47 , C07K14/7151 , C07K19/00 , C07K2319/00 , G01N33/6803 , H01J37/20 , H01J37/261 , H01J37/295 , H01J2237/201 , H01J2237/2802 , H01J2237/2803
摘要: Protein layers (1) repeating regularly in two dimensions comprise protein protomers (2) which each comprise at least two monomers (5), (6) genetically fused together. The monomers (5), (6) are monomers of respective oligomer assemblies (3), (4) into which the monomers are assembled to assembly of the protein layer. The first oligomer assembly (3) belongs to a dihedral point group of order O, where O equals (3), (4) or (6) and has a set of O rotational symmetry axes of order (2). The second oligomer assembly (4) has a rotational symmetry axis of order (2). Due to the symmetry of the oligomer assemblies (3), (4), the rotational symmetry axes of each second oligomer assembly (4) is aligned with one of said set of O rotational symmetry axes of a first oligomer assembly (3) with (2) protomers being arranged symmetrically therearound. Thus, an 2-fold fusion between the oligomer assemblies (3), (4) is produced and the arrangements of the rotational symmetry axes of the oligomer assemblies (3), (4) cause the protein layer to repeat regularly. The protein layer has many uses, for example to support molecular entities for biosensing, x-ray crystallography or electron microscopy.
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公开(公告)号:US09907858B2
公开(公告)日:2018-03-06
申请号:US14997764
申请日:2016-01-18
申请人: Immunwork Inc.
发明人: Tse-Wen Chang , Hsing-Mao Chu
IPC分类号: C07K16/46 , C07K16/30 , C07K16/24 , C07K16/18 , C07K16/28 , C07K16/22 , A61K47/48 , A61K31/4745 , A61K31/537 , A61K31/739 , C07K16/32 , C07K14/655 , C07K14/715 , C07K14/485 , A61K31/397 , A61K31/4709 , A61K31/4545
CPC分类号: A61K47/6803 , A61K31/397 , A61K31/4545 , A61K31/4709 , A61K31/4745 , A61K31/537 , A61K31/739 , A61K47/58 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/6801 , A61K47/6843 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K51/065 , A61K51/088 , A61K2039/505 , C07K14/485 , C07K14/655 , C07K14/705 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/94 , C07K2319/30 , C07K2319/32 , C07K2319/33
摘要: The present disclosure provides various molecular constructs having a targeting element and/or an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
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公开(公告)号:US20180044423A1
公开(公告)日:2018-02-15
申请号:US15689163
申请日:2017-08-29
发明人: Hilmar Erhard Ebersbach , Thomas Huber , Julia Jascur , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号: C07K16/28 , A61K31/711 , A61K35/28 , A61K38/17 , A61K39/395 , A61K48/00 , C07K14/725 , A61K31/436 , C07K14/715 , C07K16/30 , C07K14/705 , A61K45/06 , A61K38/00 , A61K39/00
CPC分类号: C07K16/2851 , A61K31/436 , A61K31/711 , A61K35/28 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/7056 , C07K14/70578 , C07K14/7151 , C07K16/2803 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/70 , A61K2300/00
摘要: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
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公开(公告)号:US20170305988A1
公开(公告)日:2017-10-26
申请号:US15645623
申请日:2017-07-10
IPC分类号: C07K14/525 , C07K14/715 , C40B40/10 , C40B40/02
CPC分类号: C07K14/525 , C07K14/7151 , C40B40/02 , C40B40/10
摘要: The present invention provides a peptide selected from the following (i) and (ii): (i) a peptide having the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing; and (ii) a peptide having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing by the conservative amino acid substitution, deletion, addition, or insertion of 1 to 28 (inclusive) amino acids except at the 1st Xaa to the 11th Xaa counting from the amino terminus.
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公开(公告)号:US09770510B2
公开(公告)日:2017-09-26
申请号:US15209484
申请日:2016-07-13
发明人: Mark Manning , Brian Murphy
IPC分类号: C07K14/705 , A61K38/17 , A61K47/10 , A61K47/26 , A61K39/395 , C07K14/715 , A61K9/16 , A61K9/14 , A61K9/00 , A61K9/08 , A61K47/18
CPC分类号: A61K47/26 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/16 , A61K38/17 , A61K38/1793 , A61K39/39591 , A61K47/10 , A61K47/18 , C07K14/705 , C07K14/7151 , C07K2319/30
摘要: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
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公开(公告)号:US09765139B2
公开(公告)日:2017-09-19
申请号:US14226522
申请日:2014-03-26
发明人: Ela Puchacz , James Russell Grove
IPC分类号: C12N15/79 , C07K14/715 , C07K16/24 , C07K14/705 , C12P21/02 , C07K19/00 , C12N5/16 , C12M1/00
CPC分类号: C07K16/241 , C07K14/70575 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12M29/10 , C12N5/16 , C12N15/79 , C12P21/02
摘要: Production of etanercept using perfusion methods achieves attractive yields of properly folded protein. Desired temperature, feed media, titers and percent correctly folded protein are disclosed.
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公开(公告)号:US20170239359A1
公开(公告)日:2017-08-24
申请号:US15454244
申请日:2017-03-09
IPC分类号: A61K47/38 , A61K31/05 , A61K8/35 , A61K9/06 , A23L29/20 , A61K8/34 , A61K8/02 , A61K8/04 , A61Q11/00 , A61K38/17 , A61K47/10 , A61K8/73
CPC分类号: A61K47/38 , A23L29/20 , A23V2002/00 , A61K8/0216 , A61K8/042 , A61K8/345 , A61K8/355 , A61K8/731 , A61K9/006 , A61K9/06 , A61K31/05 , A61K31/122 , A61K31/785 , A61K33/18 , A61K33/38 , A61K38/1793 , A61K38/18 , A61K38/1858 , A61K38/40 , A61K39/3955 , A61K47/10 , A61K2039/505 , A61K2800/10 , A61K2800/31 , A61K2800/591 , A61K2800/805 , A61K2800/81 , A61K2800/92 , A61Q11/00 , A61Q19/00 , C07K14/7151 , C07K16/241 , C07K2317/21 , C07K2317/76 , C07K2317/94 , C07K2319/035 , C07K2319/32 , A61K6/0026 , C08L1/286
摘要: The present disclosure relates to anhydrous hydrogels useful as mucoadhesive (oral compositions) or as topical agents and may be used to deliver an active agent such as active pharmaceutical agents (API's), coagulants, fragrances, flavors, and other actives and excipients.
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公开(公告)号:US09724390B2
公开(公告)日:2017-08-08
申请号:US15014134
申请日:2016-02-03
发明人: Austin L. Gurney
IPC分类号: A61K38/19 , C07K14/00 , C12Q1/68 , C12N15/00 , C12N15/62 , C07K14/525 , A61K39/395 , A61K45/06 , C07K14/52 , C07K16/18 , A61K39/00
CPC分类号: A61K38/19 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/7151 , C07K16/18 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2319/30 , C12N15/00 , C12N15/62 , C12Q1/68
摘要: Polypeptides and agents that bind a TNF receptor superfamily protein are disclosed, particularly agents that specifically bind GITR, OX40, or CD40. The polypeptides or agents may include fusion polypeptides, particularly polypeptides comprising GITRL, OX40L, or CD40L and/or bispecific agents. Also disclosed are methods of using the polypeptides or agents for inducing and/or enhancing the immune response, as well as methods for the treatment of diseases such as cancer.
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