公开(公告)号：US20100210672A1

公开(公告)日：2010-08-19

申请号：US12680785

申请日：2008-10-01

申请人： Barbara Bertani ,  Francesca Cardullo ,  Paolo Dambruoso ,  Paola Marzorati ,  Fabrizio Micheli ,  Alessandra Pasquarello ,  Catia Seri ,  Giovanna Tedesco

发明人： Barbara Bertani ,  Francesca Cardullo ,  Paolo Dambruoso ,  Paola Marzorati ,  Fabrizio Micheli ,  Alessandra Pasquarello ,  Catia Seri ,  Giovanna Tedesco

IPC分类号： A61K31/506 ,  C07D403/14 ,  A61P25/18 ,  A61P25/30

CPC分类号： C07D413/14 ,  C07D403/14 ,  C07D417/14 ,  C07D491/052

摘要： The present invention relates to novel compounds of formula (I) or a salt thereof: whereinR1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5; and n is 1 or 2; their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.

摘要翻译： 本发明涉及新的式（I）化合物或其盐：其中R 1是5元杂芳基，任选地与6元杂或碳环稠合; 这样的5或11元系可以任选被1,2,3或4个选自以下的取代基取代：卤素，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，C 1-4烷酰基，卤代C 1-4烷基， 4烷氧基和SF5; n为1或2; 它们在治疗中的用途，作为多巴胺D3受体的调节剂，例如。 治疗药物依赖性，作为抗精神病药，治疗强迫性强迫性疾病或早泄。

公开(公告)号：US08178549B2

公开(公告)日：2012-05-15

申请号：US12680785

申请日：2008-10-01

申请人： Barbara Bertani ,  Francesca Cardullo ,  Paolo Dambruoso ,  Paola Marzorati ,  Fabrizio Micheli ,  Alessandra Pasquarello ,  Catia Seri ,  Giovanna Tedesco

发明人： Barbara Bertani ,  Francesca Cardullo ,  Paolo Dambruoso ,  Paola Marzorati ,  Fabrizio Micheli ,  Alessandra Pasquarello ,  Catia Seri ,  Giovanna Tedesco

IPC分类号： C07D403/14 ,  C07D413/14 ,  A61K31/513

CPC分类号： C07D413/14 ,  C07D403/14 ,  C07D417/14 ,  C07D491/052

摘要： The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5; and n is 1 or 2; their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.

摘要翻译： 本发明涉及新的式（I）化合物或其盐：其中R 1是5元杂芳基，任选地与6元杂或碳环稠合; 这样的5或11元系可以任选被1,2,3或4个选自以下的取代基取代：卤素，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4烷氧基，C 1-4烷酰基，卤代C 1-4烷基， 4烷氧基和SF5; n为1或2; 它们在治疗中的用途，作为多巴胺D3受体的调节剂，例如。 治疗药物依赖性，作为抗精神病药，治疗强迫性强迫性疾病或早泄。