公开(公告)号：US20130309204A1

公开(公告)日：2013-11-21

申请号：US13982759

申请日：2012-02-02

申请人： Paul Edward Bonnett ,  Carolyn Estep Moore ,  Michael Burbach

发明人： Paul Edward Bonnett ,  Carolyn Estep Moore ,  Michael Burbach

IPC分类号： A61K35/74

CPC分类号： A61K35/74 ,  A01N37/46 ,  A01N51/00 ,  A01N63/00 ,  C05F11/08 ,  C05G3/02 ,  A01N43/36 ,  A01N2300/00

摘要： Methods of preserving the life span of nitrogen-fixing bacteria in agricultural pesticide formulations using vegetable oils.

摘要翻译： 使用植物油保持农药配方中固氮菌寿命的方法。

公开(公告)号：US20120065239A1

公开(公告)日：2012-03-15

申请号：US13198739

申请日：2011-08-05

申请人： Hans Tobler ,  Harald Walter ,  Josef Ehrenfreund ,  Camilla Corsi ,  Fanny Giordano ,  Martin Zeller ,  Gottfried Seifert ,  Shailesh Shah ,  Neil George ,  Ian Kevin Jones ,  Paul Edward Bonnett

发明人： Hans Tobler ,  Harald Walter ,  Josef Ehrenfreund ,  Camilla Corsi ,  Fanny Giordano ,  Martin Zeller ,  Gottfried Seifert ,  Shailesh Shah ,  Neil George ,  Ian Kevin Jones ,  Paul Edward Bonnett

IPC分类号： A01N43/56 ,  A01P3/00 ,  C07D231/14

CPC分类号： C07C211/61 ,  A01N43/56 ,  C07C205/06 ,  C07C209/325 ,  C07C209/70 ,  C07C2603/66 ,  C07D231/14

摘要： The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.

摘要翻译： 本发明涉及一种制备式Ⅰ化合物的方法，其中R1和R2分别独立地为氢或C1-C5烷基，R3为CF3或CF2H，通过a）式II化合物的反应其中R 1和 R 2如式I所定义，与至少一种还原剂形成下式化合物，其中R 1和R 2如式I所定义，和b）该化合物与至少一种还原剂的反应形成式 IV其中R1和R2如式I所定义，和（c）该化合物与式V化合物的反应，其中Q是氯，氟，溴，碘，羟基或C 1 -C 6烷氧基，R 3如式I所定义 ，形成式I化合物; 以及用于该过程的新型中间体。

公开(公告)号：US08318789B2

公开(公告)日：2012-11-27

申请号：US12532212

申请日：2008-03-20

申请人： Neil George ,  James Forrest ,  Paul Edward Bonnett ,  Pauline Theresa Gavin

发明人： Neil George ,  James Forrest ,  Paul Edward Bonnett ,  Pauline Theresa Gavin

IPC分类号： A61K31/4196 ,  C07D249/08

CPC分类号： C07D405/06

摘要： The present invention relates to co-crystals of propiconazole and a co-crystal forming compound.

摘要翻译： 本发明涉及丙环唑与共晶形成化合物的共晶体。

公开(公告)号：US20130203832A1

公开(公告)日：2013-08-08

申请号：US12531503

申请日：2008-02-19

申请人： Paul Edward Bonnett ,  Neil George ,  Ian Kevin Jones ,  Shailesh Shah

发明人： Paul Edward Bonnett ,  Neil George ,  Ian Kevin Jones ,  Shailesh Shah

IPC分类号： C07D231/14 ,  A01N43/56

CPC分类号： C07D231/14 ,  A01N43/56

摘要： The present invention relates to novel solid forms of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide, such as crystal modifications and hydrates, compositions comprising these novel solid forms and to the use thereof in the control of disease infestation in cultivated plants.

摘要翻译： 本发明涉及新型固体形式的3-二氟甲基-1-甲基-1H-吡唑-4-羧酸（9-异丙基-1,2,3,4-四氢-1,4-亚甲基 - 萘-5-基） 吡啶基） - 酰胺，例如晶体修饰物和水合物，包含这些新型固体形式的组合物及其在控制栽培植物中疾病侵袭的用途。

公开(公告)号：US07994341B2

公开(公告)日：2011-08-09

申请号：US12066683

申请日：2006-09-14

申请人： Hans Tobler ,  Harald Walter ,  Josef Ehrenfreund ,  Camilla Corsi ,  Fanny Giordano ,  Martin Zeller ,  Gottfried Seifert ,  Shailesh Shah ,  Neil George ,  Ian Kevin Jones ,  Paul Edward Bonnett

发明人： Hans Tobler ,  Harald Walter ,  Josef Ehrenfreund ,  Camilla Corsi ,  Fanny Giordano ,  Martin Zeller ,  Gottfried Seifert ,  Shailesh Shah ,  Neil George ,  Ian Kevin Jones ,  Paul Edward Bonnett

IPC分类号： C07D231/14

CPC分类号： C07C211/61 ,  A01N43/56 ,  C07C205/06 ,  C07C209/325 ,  C07C209/70 ,  C07C2603/66 ,  C07D231/14

摘要： The present invention relates to a process for the preparation of compounds of formula (I) wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula (II) wherein R1 and R2 are as defined for formula (I), with at least one reducing agent to form a compound of formula (III) wherein R1 and R2 are as defined for formula (I), and b) reaction of that compound with at least one reducing agent to form a compound of formula (IV) wherein R1 and R2 are as defined for formula (I), and (c) reaction of that compound with a compound of formula (V) wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula (I), to form the compound of formula (I); and to novel intermediates for use in that process.

摘要翻译： 本发明涉及制备式（I）化合物的方法，其中R 1和R 2各自独立地为氢或C 1 -C 5烷基，R 3为CF 3或CF 2 H，通过a）式（Ⅱ）化合物 ）其中R1和R2如式（I）所定义，与至少一种还原剂形成式（III）化合物，其中R 1和R 2如式（I）所定义，和b）该化合物与 至少一种还原剂形成式（Ⅳ）化合物，其中R1和R2如式（Ⅰ）所定义，和（c）该化合物与式（Ⅴ）化合物的反应其中Q是氯，氟， 溴，碘，羟基或C 1 -C 6烷氧基，R 3如式（I）所定义，形成式（I）化合物; 以及用于该过程的新型中间体。

公开(公告)号：US20100179204A1

公开(公告)日：2010-07-15

申请号：US12532212

申请日：2008-03-20

申请人： Neil George ,  James Forrest ,  Paul Edward Bonnett ,  Pauline Theresa Gavin

发明人： Neil George ,  James Forrest ,  Paul Edward Bonnett ,  Pauline Theresa Gavin

IPC分类号： A01N43/653 ,  C07D405/06 ,  A01P3/00

CPC分类号： C07D405/06

摘要： The present invention relates to co-crystals of propiconazole and a co-crystal forming compound.

摘要翻译： 本发明涉及丙环唑与共晶形成化合物的共晶体。

公开(公告)号：US08580835B2

公开(公告)日：2013-11-12

申请号：US12531503

申请日：2008-02-19

申请人： Paul Edward Bonnett ,  Neil George ,  Ian Kevin Jones ,  Shailesh Shah

发明人： Paul Edward Bonnett ,  Neil George ,  Ian Kevin Jones ,  Shailesh Shah

IPC分类号： C07D231/14

CPC分类号： C07D231/14 ,  A01N43/56

摘要： The present invention relates to novel solid forms of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide, such as crystal modifications and hydrates, compositions comprising these novel solid forms and to the use thereof in the control of disease infestation in cultivated plants.

摘要翻译： 本发明涉及新型固体形式的3-二氟甲基-1-甲基-1H-吡唑-4-羧酸（9-异丙基-1,2,3,4-四氢-1,4-亚甲基 - 萘-5-基） 吡啶基） - 酰胺，例如晶体修饰物和水合物，包含这些新型固体形式的组合物及其在控制栽培植物中疾病侵袭的用途。

公开(公告)号：US20090163569A1

公开(公告)日：2009-06-25

申请号：US12066683

申请日：2006-09-14

申请人： Hans Tobler ,  Harald Walter ,  Josef Ehrenfreund ,  Camilla Corsi ,  Fanny Giordano ,  Martin Zeller ,  Gottfried Seifert ,  Shailesh Shah ,  Neil George ,  Ian Kevin Jones ,  Paul Edward Bonnett

发明人： Hans Tobler ,  Harald Walter ,  Josef Ehrenfreund ,  Camilla Corsi ,  Fanny Giordano ,  Martin Zeller ,  Gottfried Seifert ,  Shailesh Shah ,  Neil George ,  Ian Kevin Jones ,  Paul Edward Bonnett

IPC分类号： A01N43/56 ,  C07D231/14 ,  C07C211/45 ,  C07C205/11 ,  C07D403/12 ,  A01P7/00

CPC分类号： C07C211/61 ,  A01N43/56 ,  C07C205/06 ,  C07C209/325 ,  C07C209/70 ,  C07C2603/66 ,  C07D231/14

摘要： The present invention relates to a process for the preparation of compounds of formula (I) wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula (II) wherein R1 and R2 are as defined for formula (I), with at least one reducing agent to form a compound of formula (III) wherein R1 and R2 are as defined for formula (I), and b) reaction of that compound with at least one reducing agent to form a compound of formula (IV) wherein R1 and R2 are as defined for formula (I), and (c) reaction of that compound with a compound of formula (V) wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula (I), to form the compound of formula (I); and to novel intermediates for use in that process.

摘要翻译： 本发明涉及制备式（I）化合物的方法，其中R 1和R 2各自独立地为氢或C 1 -C 5烷基，R 3为CF 3或CF 2 H，通过a）式（Ⅱ）化合物 ）其中R1和R2如式（I）所定义，与至少一种还原剂形成式（III）化合物，其中R 1和R 2如式（I）所定义，和b）该化合物与 至少一种还原剂形成式（Ⅳ）化合物，其中R1和R2如式（Ⅰ）所定义，和（c）该化合物与式（Ⅴ）化合物的反应其中Q是氯，氟， 溴，碘，羟基或C 1 -C 6烷氧基，R 3如式（I）所定义，形成式（I）化合物; 以及用于该过程的新型中间体。