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22 条记录 (耗时 0.039 秒)

    Process for the Synthesis of Mandipropamid and Derivatives Thereof
    6.
    发明申请
    Process for the Synthesis of Mandipropamid and Derivatives Thereof 有权

    公开(公告)号：US20090118532A1

    公开(公告)日：2009-05-07

    申请号：US12063907

    申请日：2006-08-08

    申请人： Martin Charles Bowden ,  Thomas Aitcheson Clark ,  Fanny Giordano ,  Beat Jau ,  Hans-Dieter Schneider ,  Gottfried Seifert ,  Martin Zeller ,  Dominik Faber ,  Juerg Wiss

    发明人： Martin Charles Bowden ,  Thomas Aitcheson Clark ,  Fanny Giordano ,  Beat Jau ,  Hans-Dieter Schneider ,  Gottfried Seifert ,  Martin Zeller ,  Dominik Faber ,  Juerg Wiss

    IPC分类号： C07C255/37 ,  C07C231/02 ,  C07C231/06 ,  C07C43/23 ,  C07C213/02

    CPC分类号： C07C231/12 ,  C07C33/46 ,  C07C59/70 ,  C07C69/734 ,  C07C213/02 ,  C07C235/34 ,  C07C251/16 ,  C07C255/37 ,  C07C315/04 ,  C07C319/20 ,  C07C317/46 ,  C07C323/62

    摘要： A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to carry one or more identical or different halogen atoms; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkysulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; amino; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; and n is an integer from 0 to 3, said process comprising: (i) the reaction of a compound of formula (III) wherein R, R1 and n are as hereinbefore defined; m and m′ are independently 0 or 1; when m and m′ are both 0, A is an alkyl, alkenyl or alkynyl group (suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when one of m and m′ is 0 and the other is 1, A is an alkanediyl, alkenediyl or alkynediyl group containing at least two carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when m and m′ are both 1, A is an alkanetriyl, alkenetriyl or alkynetriyl group containing at least three carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; and wherein if the group A contains three or more carbon atoms, one or more of the carbon atoms may each optionally be replaced with an oxygen atom, provided that there is at least one carbon atom between any two oxygen atoms in the molecule, with a compound of formula (IV) to give a compound of formula (II) wherein R, R1 and n are as hereinbefore defined, and (ii) the reaction of a compound of formula (II) with, wherein L is a leaving group, to give the compound of formula (I) as hereinbefore defined, is disclosed.

    Process for preparation of propionic acid derivatives
    9.
    发明授权
    Process for preparation of propionic acid derivatives 有权
    丙酸衍生物的制备方法

    公开(公告)号：US06175018B1

    公开(公告)日：2001-01-16

    申请号：US09270925

    申请日：1999-03-16

    申请人： Gottfried Seifert ,  Andrea Rolf Sting ,  Bernhard Urwyler

    发明人： Gottfried Seifert ,  Andrea Rolf Sting ,  Bernhard Urwyler

    IPC分类号： C07D21364

    CPC分类号： C07D213/643

    摘要： (R)(+)-2-[4-(5-chloro 3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid propinyl ester is produced by converting a compound of formula II in an inert organic solvent, without isolation of the intermediate products, with M2CO3, in which M is sodium or potassium, into the compound of formula III reacting this with the compound of formula IV to form the compound of formula V and converting this with a compound of formula VI wherein Z signifies phenylsulphonyl, tosyl, methylsulphonyl, nosyl, bromophenyl, Cl-, Br- or CICO-, into the compound of formula I.

    摘要翻译： （R）（+） - 2- [4-（5-氯-3-氟吡啶-2-基氧基） - 苯氧基] - 丙酸丙酯通过在惰性有机溶剂中转化式II化合物而不分离 中间产物，其中M为钠或钾的M 2 C 3与式IV化合物反应，形成式V化合物，并与式VI化合物反应，其中Z表示苯基磺酰基，甲苯磺酰基，甲基磺酰基， ，溴苯基，Cl-，Br-或CICO-转化成式I的化合物。

    Method of producing nitroguanidine- and nitroenamine derivatives
    10.
    发明授权
    Method of producing nitroguanidine- and nitroenamine derivatives 有权
    制备硝基胍和硝基胺衍生物的方法

    公开(公告)号：US06747146B2

    公开(公告)日：2004-06-08

    申请号：US10325559

    申请日：2002-12-20

    申请人： Gottfried Seifert ,  Thomas Rapold ,  Verena Gisin

    发明人： Gottfried Seifert ,  Thomas Rapold ,  Verena Gisin

    IPC分类号： C07D27304

    CPC分类号： C07D213/40 ,  C07C257/22 ,  C07C261/00 ,  C07C277/08 ,  C07D213/38 ,  C07D277/28 ,  C07D307/14 ,  C07D401/06 ,  C07D417/06 ,  C07C279/36

    摘要： Method of producing compounds of formula wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cycloalkyl, or a radical —N(R3)R4; or R2 and R6 together are —CH2—CH2—S—; R3 and R4 are hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl or a radical —CH2B; R6 is hydrogen, C1-C8-alkyl, aryl or benzyl; or R3 and R6 together are —CH2—CH2—, —CH2—CH2—CH2—, —CH2—O—CH2—, —CH2—S—CH2— or —CH2—N(R5)—CH2—; X is CH—CN; CH—NO2 or N—NO2; A is an optionally substituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical; and B is optionally substituted phenyl, 3-pyridyl or thiazolyl; characterised in that a compound of formula wherein R2, R6 and X have the same significance as given above in formula (I), is reacted in the presence of a phase transfer catalyst and a base with a compound of formula wherein A and R1 have the same significance as given above in formula (I) and Q is a leaving group.

    摘要翻译： 制备糠醛的化合物的方法是氢或C 1 -C 4烷基; R 2是氢，C 1 -C 8烷基，C 3 -C 6环烷基或-N（R 3）R 4基团; 或R 2和R 6一起是-CH 2 -CH 2 -S-; R 3和R 4是氢，C 1 -C 4 - 烷基，C 3 -C 6环烷基或基团-CH 2 B; R 6是氢，C 1 -C 8 - 烷基，芳基或苄基 ;或R 3和R 6一起是-CH 2 -CH 2 - ， - CH 2 -CH 2 - ， - CH 2 -O-CH 2 - ， - CH 2 -S-CH 2 - 或-CH 2 -N（R 5）-CH 2 - ; X是 CH-CN; CH-NO 2或N-NO 2; A是任选取代的芳族或非芳族单环或双环杂环基; 和B是任选取代的苯基，3-吡啶基或噻唑基;其特征在于，式（I）化合物与式（I）中所给出的具有相同意义的化合物在相转移催化剂和碱的存在下反应 与式（I）中的上述式相同，Q为离去基团。