公开(公告)号：US07235047B2

公开(公告)日：2007-06-26

申请号：US10688783

申请日：2003-10-17

申请人： Calum E. MacAulay ,  Andrew L. P. Dlugan ,  Pierre M. Lane

发明人： Calum E. MacAulay ,  Andrew L. P. Dlugan ,  Pierre M. Lane

IPC分类号： A61B1/07 ,  G02B6/43 ,  G02B26/08

CPC分类号： A61B1/00172 ,  A61B1/00165 ,  A61B1/07 ,  G02B6/06 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0056 ,  G02B21/0072 ,  G02B23/2453 ,  G02B23/26

摘要： Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.

摘要翻译： 内窥镜和其他观察装置，其控制接触样品的光和/或从样品发出的光。 观察装置特别适用于体内成像，尽管也包括其它用途。 观察装置及其相关方法包括在照明和/或检测光路中的空间光调制器，使得经由一束光导或光学系统传输到目标的光基本上仅被传输到光导的核心 束并且不包围围绕光导的包层，束中的光导之间的填充物或不期望的光导。 此外，用于将空间光调制器的像素映射到束中的光导体的核心（优选地，每个核心的至少3个像素（例如，用于数字微镜器件的至少3个反射镜））的方法和装置）以及 用于将一个光导束的光导映射到另一个。

公开(公告)号：US06794658B2

公开(公告)日：2004-09-21

申请号：US10165168

申请日：2002-06-06

申请人： Calum E. MacAulay ,  Pierre M. Lane

发明人： Calum E. MacAulay ,  Pierre M. Lane

IPC分类号： G01N2164

CPC分类号： G01N21/6452 ,  G01N21/253 ,  G02B26/02 ,  G02B27/021

摘要： Microarray readers and methods that compensate for target spots that are too dim or too bright for the microarray reader to accurately measure. The readers adjust the amount of light directed at or received from specific non-acceptable target spots, such that dim spots receive more excitation light and overly bright spots receive less. This increases or decreases, respectively, their measured brightness, which in turn effectively increases the range over which a microarray reader can accurately measure the spots, and can also improve the signal-to-noise ratio and other aspects of the measurements.

摘要翻译： 微阵列阅读器和补偿微阵列阅读器准确测量的目标斑点太暗或太亮的方法。 读者调节指向或从特定不可接受的目标点接收的光量，使得暗点接收更多的激发光并且过亮点接收较少。 它们分别增加或减少它们的测量亮度，这反过来有效地增加了微阵列读取器可精确测量斑点的范围，并且还可以提高测量的信噪比和其他方面。

公开(公告)号：US06663560B2

公开(公告)日：2003-12-16

申请号：US09738257

申请日：2000-12-14

申请人： Calum E. MacAulay ,  Andrew L. P. Dlugan ,  Pierre M. Lane

发明人： Calum E. MacAulay ,  Andrew L. P. Dlugan ,  Pierre M. Lane

IPC分类号： A61B106

CPC分类号： A61B1/00172 ,  A61B1/00165 ,  A61B1/07 ,  G02B6/06 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0056 ,  G02B21/0072 ,  G02B23/2453 ,  G02B23/26

摘要： Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.

摘要翻译： 内窥镜和其他观察装置，其控制接触样品的光和/或从样品发出的光。 观察装置特别适用于体内成像，尽管也包括其它用途。 观察装置及其相关方法包括在照明和/或检测光路中的空间光调制器，使得经由一束光导或光学系统传输到目标的光基本上仅被传输到光导的核心 束并且不包围围绕光导的包层，束中的光导之间的填充物或不期望的光导。 此外，用于将空间光调制器的像素映射到束中的光导体的核心（优选地，每个核心的至少3个像素（例如，至少3个数字微镜装置的反射镜））的方法和装置）以及 用于将一个光导束的光导映射到另一个。

公开(公告)号：US20090244272A1

公开(公告)日：2009-10-01

申请号：US12259232

申请日：2008-10-27

申请人： Calum E. MacAulay ,  Andrew L.P. Dlugan ,  Pierre M. Lane

发明人： Calum E. MacAulay ,  Andrew L.P. Dlugan ,  Pierre M. Lane

IPC分类号： H04N7/18

CPC分类号： A61B1/00172 ,  A61B1/00165 ,  A61B1/07 ,  G02B6/06 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0056 ,  G02B21/0072 ,  G02B23/2453 ,  G02B23/26

摘要： Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.

摘要翻译： 内窥镜和其他观察装置，其控制接触样品的光和/或从样品发出的光。 观察装置特别适用于体内成像，尽管也包括其它用途。 观察装置及其相关方法包括在照明和/或检测光路中的空间光调制器，使得经由一束光导或光学系统传输到目标的光基本上仅被传输到光导的核心 束并且不包围围绕光导的包层，束中的光导之间的填充物或不期望的光导。 此外，用于将空间光调制器的像素映射到束中的光导体的核心（优选地，每个核心的至少3个像素（例如，至少3个数字微镜装置的反射镜））的方法和装置）以及 用于将一个光导束的光导映射到另一个。